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Article: Optimal Regeneration and Repair of Critical Size Articular Cartilage Driven by Endogenous CLECSF1

TitleOptimal Regeneration and Repair of Critical Size Articular Cartilage Driven by Endogenous CLECSF1
Authors
KeywordsC-type lectin
Cartilage tissue engineering
Recombinant lentiviral vector
Stem cells
Issue Date1-Sep-2022
PublisherElsevier
Citation
Biomedical Signal Processing and Control, 2022, v. 78 How to Cite?
Abstract

Due to the lack of blood supply and nerve in articular cartilage, it is a great challenge to repair critical size cartilage defect, to maintain the phenotype of new chondrocytes and to restore joint function. We find that the endogenous cartilage extracellular matrix specific protein C-type lectin (CLECSF1) can be applied for the repair of cartilage defect. The endogenous expression of CLECSF1 can be achieved by integrating its coding gene into the recombinant lentiviral vectors. These vectors are used to transfect into bone marrow mesenchymal stem cells (BMSCs) and then these transfected BMSCs are seeded in a scaffold. We reveal that such scaffold can promote chondrogenic differentiation, enhance cartilage extracellular matrix deposition and maintain chondrocyte phenotype. Furthermore, such scaffold can repair critical size cartilage defect and finally achieve a full recovery of both structure and function. Therefore, we believe that such scaffold can be an ideal alternative strategy for the treatment of critical size cartilage defect in future. 


Persistent Identifierhttp://hdl.handle.net/10722/332214
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.284
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, TJ-
dc.contributor.authorCao, F-
dc.contributor.authorPeng, WZ-
dc.contributor.authorWei, R-
dc.contributor.authorXu, QZ-
dc.contributor.authorFeng, B-
dc.contributor.authorWang, JX-
dc.contributor.authorWeng, J-
dc.contributor.authorWang, M-
dc.contributor.authorZhang, XD-
dc.date.accessioned2023-10-04T07:20:57Z-
dc.date.available2023-10-04T07:20:57Z-
dc.date.issued2022-09-01-
dc.identifier.citationBiomedical Signal Processing and Control, 2022, v. 78-
dc.identifier.issn1746-8094-
dc.identifier.urihttp://hdl.handle.net/10722/332214-
dc.description.abstract<p>Due to the lack of blood supply and nerve in articular cartilage, it is a great challenge to repair critical size cartilage defect, to maintain the phenotype of new chondrocytes and to restore joint function. We find that the endogenous cartilage extracellular matrix specific protein C-type lectin (CLECSF1) can be applied for the repair of cartilage defect. The endogenous expression of CLECSF1 can be achieved by integrating its coding gene into the recombinant lentiviral vectors. These vectors are used to transfect into bone marrow mesenchymal stem cells (BMSCs) and then these transfected BMSCs are seeded in a scaffold. We reveal that such scaffold can promote chondrogenic differentiation, enhance cartilage extracellular matrix deposition and maintain chondrocyte phenotype. Furthermore, such scaffold can repair critical size cartilage defect and finally achieve a full recovery of both structure and function. Therefore, we believe that such scaffold can be an ideal alternative strategy for the treatment of critical size cartilage defect in future.<span> </span></p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofBiomedical Signal Processing and Control-
dc.subjectC-type lectin-
dc.subjectCartilage tissue engineering-
dc.subjectRecombinant lentiviral vector-
dc.subjectStem cells-
dc.titleOptimal Regeneration and Repair of Critical Size Articular Cartilage Driven by Endogenous CLECSF1-
dc.typeArticle-
dc.identifier.doi10.1016/j.bspc.2022.103898-
dc.identifier.scopuseid_2-s2.0-85132375590-
dc.identifier.volume78-
dc.identifier.eissn1746-8108-
dc.identifier.isiWOS:000814368000004-
dc.identifier.issnl1746-8094-

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