File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Impact of host genetic polymorphisms on response to inactivated influenza vaccine in children

TitleImpact of host genetic polymorphisms on response to inactivated influenza vaccine in children
Authors
Issue Date20-Feb-2023
PublisherSpringer Nature in partnership with the Sealy Center for Vaccine Development
Citation
NPJ vaccines., 2023, v. 8, n. 1 How to Cite?
Abstract

In randomized controlled trials of influenza vaccination, 550 children received trivalent-inactivated influenza vaccine, permitting us to explore relationship between vaccine response and host single nucleotide polymorphisms (SNPs) in 23 candidate genes with adjustment of multiple testing. For host SNPs in TLR7-1817G/T (rs5741880), genotype GT was associated with lower odds (OR: 0.22, 95% CI: 0.09, 0.53) of have post-vaccination hemagglutination-inhibiting (HAI) titers >= 40, compared with genotype GG and TT combined under the over-dominant model. For host SNPs in TLR8-129G/C (rs3764879), genotype GT was associated with lower odds (OR: 0.47; 95% CI: 0.28, 0.80) of have post vaccination HAI titers >= 40 compared with genotype GG and AA combined under the over-dominant model. Our results could contribute to the development of better vaccines that may offer improved protection to all recipients.


Persistent Identifierhttp://hdl.handle.net/10722/332052
ISSN
2023 Impact Factor: 6.9
2023 SCImago Journal Rankings: 2.127
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsang, Tim K-
dc.contributor.authorWang, Can-
dc.contributor.authorTsang, Nicole N Y-
dc.contributor.authorFang, Vicky J-
dc.contributor.authorPerera, Ranawaka A P M-
dc.contributor.authorPeiris, Malik J S-
dc.contributor.authorLeung, Gabriel M-
dc.contributor.authorCowling, Benjamin J-
dc.contributor.authorIp, Dennis K M-
dc.date.accessioned2023-09-28T05:00:31Z-
dc.date.available2023-09-28T05:00:31Z-
dc.date.issued2023-02-20-
dc.identifier.citationNPJ vaccines., 2023, v. 8, n. 1-
dc.identifier.issn2059-0105-
dc.identifier.urihttp://hdl.handle.net/10722/332052-
dc.description.abstract<p>In randomized controlled trials of influenza vaccination, 550 children received trivalent-inactivated influenza vaccine, permitting us to explore relationship between vaccine response and host single nucleotide polymorphisms (SNPs) in 23 candidate genes with adjustment of multiple testing. For host SNPs in TLR7-1817G/T (rs5741880), genotype GT was associated with lower odds (OR: 0.22, 95% CI: 0.09, 0.53) of have post-vaccination hemagglutination-inhibiting (HAI) titers >= 40, compared with genotype GG and TT combined under the over-dominant model. For host SNPs in TLR8-129G/C (rs3764879), genotype GT was associated with lower odds (OR: 0.47; 95% CI: 0.28, 0.80) of have post vaccination HAI titers >= 40 compared with genotype GG and AA combined under the over-dominant model. Our results could contribute to the development of better vaccines that may offer improved protection to all recipients.<br></p>-
dc.languageeng-
dc.publisherSpringer Nature in partnership with the Sealy Center for Vaccine Development-
dc.relation.ispartofNPJ vaccines.-
dc.titleImpact of host genetic polymorphisms on response to inactivated influenza vaccine in children-
dc.typeArticle-
dc.identifier.doi10.1038/s41541-023-00621-1-
dc.identifier.scopuseid_2-s2.0-85148738594-
dc.identifier.volume8-
dc.identifier.issue1-
dc.identifier.eissn2059-0105-
dc.identifier.isiWOS:000944665400001-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats