File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A Unified Therapeutic–Prophylactic Tissue‐Engineering Scaffold Demonstrated to Prevent Tumor Recurrence and Overcoming Infection toward Bone Remodeling

TitleA Unified Therapeutic–Prophylactic Tissue‐Engineering Scaffold Demonstrated to Prevent Tumor Recurrence and Overcoming Infection toward Bone Remodeling
Authors
Keywordsbacteriostasis
bone repair
gadolinium
MRI
oncotherapy
photothermal therapy
Issue Date2-May-2023
PublisherWiley
Citation
Advanced Materials, 2023, v. 35, n. 25 How to Cite?
Abstract

Osteosarcoma occurs in children and adolescents frequently and leads to a high fatality rate. Although surgical resection is the most common methods in clinic, patients always suffer from tumor metastasis and recurrence and it is difficult for them to self-repair large bone defects. Furthermore, the postoperative infection from bacteria triggers an inflammatory response and hinders the bone-repair process. This work demonstrates a gadolinium (Gd)-complex and molybdenum sulfide (MoS2) co-doped N-acryloyl glycinamide (NAGA)/gelatin methacrylate (Gel-MA) multifunctional hydrogel (GMNG). The combination between NAGA and Gel-MA endows the GMNG with attractive mechanical properties and controllable degradation ability. The MoS2 improves the hydrogel system, which has excellent photothermal ability to kill tumor cells and inhibit bacterial infection both in vitro and in vivo. Based on the Gd-complex, the magnetic resonance imaging (MRI) effect can be used to monitor the position and degradation situation of the hydrogel. Notably, accompanied by the degradation of GMNG hydrogel, the gradually released Gd3+ from the hydrogel exhibits osteogenic property and could promote new bone formation efficiently in vivo. Therefore, this strategy supplies a method to prepare multifunctional bone-defect-repair materials and is expected to represent a significant guidance and reference to the development of biomaterials for bone tissue engineering.


Persistent Identifierhttp://hdl.handle.net/10722/332005
ISSN
2023 Impact Factor: 27.4
2023 SCImago Journal Rankings: 9.191
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHuang, Yongkang-
dc.contributor.authorZhai, Xinyun-
dc.contributor.authorMa, Tengfei-
dc.contributor.authorZhang, Mengzhen-
dc.contributor.authorYang, Houzhi-
dc.contributor.authorZhang, Shuai-
dc.contributor.authorWang, Junbo-
dc.contributor.authorLiu, Wenguang-
dc.contributor.authorJin, Xin-
dc.contributor.authorLu, William Weijia-
dc.contributor.authorZhao, Xiaoli-
dc.contributor.authorHou, Weiyu-
dc.contributor.authorSun, Tianwei-
dc.contributor.authorShen, Jie-
dc.contributor.authorPan, Haobo-
dc.contributor.authorDu Yaping,-
dc.contributor.authorYan, Chun‐Hua-
dc.date.accessioned2023-09-28T05:00:11Z-
dc.date.available2023-09-28T05:00:11Z-
dc.date.issued2023-05-02-
dc.identifier.citationAdvanced Materials, 2023, v. 35, n. 25-
dc.identifier.issn0935-9648-
dc.identifier.urihttp://hdl.handle.net/10722/332005-
dc.description.abstract<p>Osteosarcoma occurs in children and adolescents frequently and leads to a high fatality rate. Although surgical resection is the most common methods in clinic, patients always suffer from tumor metastasis and recurrence and it is difficult for them to self-repair large bone defects. Furthermore, the postoperative infection from bacteria triggers an inflammatory response and hinders the bone-repair process. This work demonstrates a gadolinium (Gd)-complex and molybdenum sulfide (MoS2) co-doped N-acryloyl glycinamide (NAGA)/gelatin methacrylate (Gel-MA) multifunctional hydrogel (GMNG). The combination between NAGA and Gel-MA endows the GMNG with attractive mechanical properties and controllable degradation ability. The MoS2 improves the hydrogel system, which has excellent photothermal ability to kill tumor cells and inhibit bacterial infection both in vitro and in vivo. Based on the Gd-complex, the magnetic resonance imaging (MRI) effect can be used to monitor the position and degradation situation of the hydrogel. Notably, accompanied by the degradation of GMNG hydrogel, the gradually released Gd3+ from the hydrogel exhibits osteogenic property and could promote new bone formation efficiently in vivo. Therefore, this strategy supplies a method to prepare multifunctional bone-defect-repair materials and is expected to represent a significant guidance and reference to the development of biomaterials for bone tissue engineering.<br></p>-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofAdvanced Materials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbacteriostasis-
dc.subjectbone repair-
dc.subjectgadolinium-
dc.subjectMRI-
dc.subjectoncotherapy-
dc.subjectphotothermal therapy-
dc.titleA Unified Therapeutic–Prophylactic Tissue‐Engineering Scaffold Demonstrated to Prevent Tumor Recurrence and Overcoming Infection toward Bone Remodeling-
dc.typeArticle-
dc.identifier.doi10.1002/adma.202300313-
dc.identifier.scopuseid_2-s2.0-85154619572-
dc.identifier.volume35-
dc.identifier.issue25-
dc.identifier.eissn1521-4095-
dc.identifier.isiWOS:000980135700001-
dc.identifier.issnl0935-9648-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats