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Article: Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder

TitlePersonality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder
Authors
Issue Date14-Jul-2022
PublisherNature Publishing Group
Citation
npj Parkinson's Disease, 2022, v. 8, n. 1 How to Cite?
Abstract

Patients with Parkinson's disease (PD) were described less extraverted and more neurotic. It remained unclear whether similar personality traits could be found in idiopathic rapid eye movement sleep behavior disorder (iRBD), a prodromal stage of PD, and could predict phenoconversion to neurodegenerative disorders. We aimed to investigate the personality profile and its association with future neurodegenerative phenoconversion in iRBD patients. One hundred and eighty-five video-polysomnography confirmed iRBD patients and 91 age- and sex-matched controls underwent personality assessment using the NEO five-factor inventory, and 171 iRBD patients were followed up. Our results showed that iRBD was marginally negatively associated with extraverted personality trait (B = -0.28, 95% confidence interval (CI) = -0.55, -0.001). During a median follow-up of 5.9 years, 47 iRBD patients {27.5%) had phenoconversion. More neurotic {adjusted hazard ratio (HR) = 2.0, 95% CI = 1.3, 3.1) and less extraverted personality traits (adjusted HR = 0.53, 95% Cl = 0.36, 0.77) were associated with an increased risk of phenoconversion in iRBD patients. Our findings suggest that personality profile may be a potential prodromal marker of iRBD.


Persistent Identifierhttp://hdl.handle.net/10722/331992
ISSN
2023 Impact Factor: 6.7
2023 SCImago Journal Rankings: 2.159
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, L-
dc.contributor.authorChau, SWH-
dc.contributor.authorLiu, YP-
dc.contributor.authorWang, J-
dc.contributor.authorZhang, JH-
dc.contributor.authorChan, NY-
dc.contributor.authorChan, JWY-
dc.contributor.authorHuang, B-
dc.contributor.authorChen, SJ-
dc.contributor.authorLi, SX-
dc.contributor.authorMok, VCT-
dc.contributor.authorWing, YK-
dc.date.accessioned2023-09-28T05:00:06Z-
dc.date.available2023-09-28T05:00:06Z-
dc.date.issued2022-07-14-
dc.identifier.citationnpj Parkinson's Disease, 2022, v. 8, n. 1-
dc.identifier.issn2373-8057-
dc.identifier.urihttp://hdl.handle.net/10722/331992-
dc.description.abstract<p></p><p>Patients with Parkinson's disease (PD) were described less extraverted and more neurotic. It remained unclear whether similar personality traits could be found in idiopathic rapid eye movement sleep behavior disorder (iRBD), a prodromal stage of PD, and could predict phenoconversion to neurodegenerative disorders. We aimed to investigate the personality profile and its association with future neurodegenerative phenoconversion in iRBD patients. One hundred and eighty-five video-polysomnography confirmed iRBD patients and 91 age- and sex-matched controls underwent personality assessment using the NEO five-factor inventory, and 171 iRBD patients were followed up. Our results showed that iRBD was marginally negatively associated with extraverted personality trait (B = -0.28, 95% confidence interval (CI) = -0.55, -0.001). During a median follow-up of 5.9 years, 47 iRBD patients {27.5%) had phenoconversion. More neurotic {adjusted hazard ratio (HR) = 2.0, 95% CI = 1.3, 3.1) and less extraverted personality traits (adjusted HR = 0.53, 95% Cl = 0.36, 0.77) were associated with an increased risk of phenoconversion in iRBD patients. Our findings suggest that personality profile may be a potential prodromal marker of iRBD.<br></p>-
dc.languageeng-
dc.publisherNature Publishing Group-
dc.relation.ispartofnpj Parkinson's Disease-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titlePersonality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41531-022-00356-1-
dc.identifier.scopuseid_2-s2.0-85134225718-
dc.identifier.volume8-
dc.identifier.issue1-
dc.identifier.eissn2373-8057-
dc.identifier.isiWOS:000825417900001-
dc.identifier.issnl2373-8057-

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