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- Publisher Website: 10.1111/jgh.16269
- Scopus: eid_2-s2.0-85162878453
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Article: Biomarkers for monitoring alcohol sobriety after liver transplantation for alcoholic liver disease
Title | Biomarkers for monitoring alcohol sobriety after liver transplantation for alcoholic liver disease |
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Authors | |
Keywords | Alcoholic liver disease Biomarker Liver transplantation Sobriety |
Issue Date | 23-Jun-2023 |
Publisher | Wiley |
Citation | Journal of Gastroenterology and Hepatology, 2023, v. 38, n. 8, p. 1227-1232 How to Cite? |
Abstract | Alcoholic liver disease (ALD) has become the most common indication for liver transplantation in Western countries, and its incidence is rapidly increasing in East Asia. Alcohol abstinence remains the standard of care for promoting liver transplantation for ALD and for preventing posttransplant graft loss. However, efficient monitoring methods are still being developed due to the limitations of traditional biomarkers, interviews, and questionnaires. The development of alcohol biomarkers has shifted from detecting alcohol and methanol to indirect byproducts, and to current mid-term and long-term direct alcohol metabolites, which provide higher accuracy and cover almost all types of alcohol relapse detection. However, in most clinical studies, biomarkers are used and validated in healthy individuals and alcohol use disorder (AUD) patients and for pretransplant evaluations. The evidence for their use in posttransplant abstinence monitoring is still lacking, but it is crucial for early detection of alcohol relapse and initiating intervention. This review aims to summarize the current evidence of the use of biomarkers for monitoring sobriety and alcohol relapse after liver transplantation, as well as to cover the diagnostic accuracy, detection window, and optimal multidisciplinary strategies. |
Persistent Identifier | http://hdl.handle.net/10722/331890 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.179 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, Jiang | - |
dc.contributor.author | Man, Kwan | - |
dc.date.accessioned | 2023-09-28T04:59:24Z | - |
dc.date.available | 2023-09-28T04:59:24Z | - |
dc.date.issued | 2023-06-23 | - |
dc.identifier.citation | Journal of Gastroenterology and Hepatology, 2023, v. 38, n. 8, p. 1227-1232 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | http://hdl.handle.net/10722/331890 | - |
dc.description.abstract | <p>Alcoholic liver disease (ALD) has become the most common indication for liver transplantation in Western countries, and its incidence is rapidly increasing in East Asia. Alcohol abstinence remains the standard of care for promoting liver transplantation for ALD and for preventing posttransplant graft loss. However, efficient monitoring methods are still being developed due to the limitations of traditional biomarkers, interviews, and questionnaires. The development of alcohol biomarkers has shifted from detecting alcohol and methanol to indirect byproducts, and to current mid-term and long-term direct alcohol metabolites, which provide higher accuracy and cover almost all types of alcohol relapse detection. However, in most clinical studies, biomarkers are used and validated in healthy individuals and alcohol use disorder (AUD) patients and for pretransplant evaluations. The evidence for their use in posttransplant abstinence monitoring is still lacking, but it is crucial for early detection of alcohol relapse and initiating intervention. This review aims to summarize the current evidence of the use of biomarkers for monitoring sobriety and alcohol relapse after liver transplantation, as well as to cover the diagnostic accuracy, detection window, and optimal multidisciplinary strategies.<br></p> | - |
dc.language | eng | - |
dc.publisher | Wiley | - |
dc.relation.ispartof | Journal of Gastroenterology and Hepatology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Alcoholic liver disease | - |
dc.subject | Biomarker | - |
dc.subject | Liver transplantation | - |
dc.subject | Sobriety | - |
dc.title | Biomarkers for monitoring alcohol sobriety after liver transplantation for alcoholic liver disease | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1111/jgh.16269 | - |
dc.identifier.scopus | eid_2-s2.0-85162878453 | - |
dc.identifier.volume | 38 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 1227 | - |
dc.identifier.epage | 1232 | - |
dc.identifier.eissn | 1440-1746 | - |
dc.identifier.isi | WOS:001014606000001 | - |
dc.identifier.issnl | 0815-9319 | - |