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Article: Profiling the Influence of Gene Variants Related to Folate-Mediated One-Carbon Metabolism on the Outcome of In Vitro Fertilization (IVF) with Donor Oocytes in Recipients Receiving Folic Acid Fortification

TitleProfiling the Influence of Gene Variants Related to Folate-Mediated One-Carbon Metabolism on the Outcome of In Vitro Fertilization (IVF) with Donor Oocytes in Recipients Receiving Folic Acid Fortification
Authors
KeywordsABCB1
ART
BHMT
embryo viability
folic acid
gene polymorphism
IVF
MTHFR
one-carbon metabolism
oocyte donation
SHMT1
Issue Date25-Sep-2022
PublisherMDPI
Citation
International Journal of Molecular Sciences, 2022, v. 23, n. 19 How to Cite?
Abstract

Nutritional status and gene polymorphisms of one-carbon metabolism confer a well-known interaction that in pregnant women may affect embryo viability and the health of the newborn. Folate metabolism directly impacts nucleotide synthesis and methylation, which is of increasing interest in the reproductive medicine field. Studies assessing the genetic influence of folate metabolism on IVF treatments have currently been performed in women using their own oocytes. Most of these patients seeking to have a child or undergoing IVF treatments are advised to preventively intake folate supplies that restore known metabolic imbalances, but the treatments could lead to the promotion of specific enzymes in specific women, depending on their genetic variance. In the present study, we assess the influence of candidate gene variants related to folate metabolism, such as Serine Hydroxymethyltransferase 1 SHMT1 (rs1979276 and rs1979277), Betaine-Homocysteine S-Methyltransferase BHMT (rs3733890), Methionine synthase reductase MTRR (rs1801394), Methylenetetrahydrofolate reductase MTHFR (rs1801131 and rs1801133), methionine synthase MTR (rs12749581), ATP Binding Cassette Subfamily B Member 1 ABCB1 (rs1045642) and folate receptor alpha FOLR1 (rs2071010) on the success of IVF treatment performed in women being recipients of donated oocytes. The implication of such gene variants seems to have no direct impact on pregnancy consecution after IVF; however, several gene variants could influence pregnancy loss events or pregnancy maintenance, as consequence of folic acid fortification.


Persistent Identifierhttp://hdl.handle.net/10722/331790
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.179
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPalomares, Arturo Reyes-
dc.contributor.authorRuiz-Galdon, Maximiliano-
dc.contributor.authorLiu, Kui-
dc.contributor.authorReyes-Engel, Armando-
dc.contributor.authorRodriguez-Wallberg, Kenny A-
dc.date.accessioned2023-09-21T06:58:56Z-
dc.date.available2023-09-21T06:58:56Z-
dc.date.issued2022-09-25-
dc.identifier.citationInternational Journal of Molecular Sciences, 2022, v. 23, n. 19-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/331790-
dc.description.abstract<p>Nutritional status and gene polymorphisms of one-carbon metabolism confer a well-known interaction that in pregnant women may affect embryo viability and the health of the newborn. Folate metabolism directly impacts nucleotide synthesis and methylation, which is of increasing interest in the reproductive medicine field. Studies assessing the genetic influence of folate metabolism on IVF treatments have currently been performed in women using their own oocytes. Most of these patients seeking to have a child or undergoing IVF treatments are advised to preventively intake folate supplies that restore known metabolic imbalances, but the treatments could lead to the promotion of specific enzymes in specific women, depending on their genetic variance. In the present study, we assess the influence of candidate gene variants related to folate metabolism, such as Serine Hydroxymethyltransferase 1 SHMT1 (rs1979276 and rs1979277), Betaine-Homocysteine S-Methyltransferase BHMT (rs3733890), Methionine synthase reductase MTRR (rs1801394), Methylenetetrahydrofolate reductase MTHFR (rs1801131 and rs1801133), methionine synthase MTR (rs12749581), ATP Binding Cassette Subfamily B Member 1 ABCB1 (rs1045642) and folate receptor alpha FOLR1 (rs2071010) on the success of IVF treatment performed in women being recipients of donated oocytes. The implication of such gene variants seems to have no direct impact on pregnancy consecution after IVF; however, several gene variants could influence pregnancy loss events or pregnancy maintenance, as consequence of folic acid fortification.<br></p>-
dc.languageeng-
dc.publisherMDPI-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectABCB1-
dc.subjectART-
dc.subjectBHMT-
dc.subjectembryo viability-
dc.subjectfolic acid-
dc.subjectgene polymorphism-
dc.subjectIVF-
dc.subjectMTHFR-
dc.subjectone-carbon metabolism-
dc.subjectoocyte donation-
dc.subjectSHMT1-
dc.titleProfiling the Influence of Gene Variants Related to Folate-Mediated One-Carbon Metabolism on the Outcome of In Vitro Fertilization (IVF) with Donor Oocytes in Recipients Receiving Folic Acid Fortification-
dc.typeArticle-
dc.identifier.doi10.3390/ijms231911298-
dc.identifier.scopuseid_2-s2.0-85139927494-
dc.identifier.volume23-
dc.identifier.issue19-
dc.identifier.eissn1422-0067-
dc.identifier.isiWOS:000867765600001-
dc.identifier.issnl1422-0067-

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