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Article: New insights into the function of Interleukin-25 in disease pathogenesis

TitleNew insights into the function of Interleukin-25 in disease pathogenesis
Authors
KeywordsAutoimmune diseases
Cancer
Clinical treatment
IL-25(IL-17E)
Inflammation
Issue Date1-Apr-2023
PublisherBioMed Central
Citation
Biomarker Research, 2023, v. 11, n. 1 How to Cite?
Abstract

Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated upon cell injury or tissue damage to activate immune cells through the interaction with IL-17RA and IL-17RB receptors. The binding of IL-25 to IL-17RA/IL-17RB complex not only initiates and maintains type 2 immunity but also regulates other immune cells (e.g., macrophages and mast cells) via various signaling pathways. It has been well-documented that IL-25 is critically involved in the development of allergic disorders (e.g., asthma). However, the roles of IL-25 in the pathogenesis of other diseases and the underlying mechanisms are still unclear. This review presents current evidence on the roles of IL-25 in cancers, allergic disorders, and autoimmune diseases. Moreover, we discuss the unanswered key questions underlying IL-25-mediated disease pathology, which will provide new insights into the targeted therapy of this cytokine in clinical treatment.


Persistent Identifierhttp://hdl.handle.net/10722/331724
ISSN
2023 Impact Factor: 9.5
2023 SCImago Journal Rankings: 3.024
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYuan, QF-
dc.contributor.authorPeng, N-
dc.contributor.authorXiao, F-
dc.contributor.authorShi, XF-
dc.contributor.authorZhu, B-
dc.contributor.authorRui, K-
dc.contributor.authorTian, J-
dc.contributor.authorLu, LW-
dc.date.accessioned2023-09-21T06:58:21Z-
dc.date.available2023-09-21T06:58:21Z-
dc.date.issued2023-04-01-
dc.identifier.citationBiomarker Research, 2023, v. 11, n. 1-
dc.identifier.issn2050-7771-
dc.identifier.urihttp://hdl.handle.net/10722/331724-
dc.description.abstract<p> Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated upon cell injury or tissue damage to activate immune cells through the interaction with IL-17RA and IL-17RB receptors. The binding of IL-25 to IL-17RA/IL-17RB complex not only initiates and maintains type 2 immunity but also regulates other immune cells (e.g., macrophages and mast cells) via various signaling pathways. It has been well-documented that IL-25 is critically involved in the development of allergic disorders (e.g., asthma). However, the roles of IL-25 in the pathogenesis of other diseases and the underlying mechanisms are still unclear. This review presents current evidence on the roles of IL-25 in cancers, allergic disorders, and autoimmune diseases. Moreover, we discuss the unanswered key questions underlying IL-25-mediated disease pathology, which will provide new insights into the targeted therapy of this cytokine in clinical treatment. <br></p>-
dc.languageeng-
dc.publisherBioMed Central-
dc.relation.ispartofBiomarker Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAutoimmune diseases-
dc.subjectCancer-
dc.subjectClinical treatment-
dc.subjectIL-25(IL-17E)-
dc.subjectInflammation-
dc.titleNew insights into the function of Interleukin-25 in disease pathogenesis-
dc.typeArticle-
dc.identifier.doi10.1186/s40364-023-00474-9-
dc.identifier.scopuseid_2-s2.0-85152545305-
dc.identifier.volume11-
dc.identifier.issue1-
dc.identifier.eissn2050-7771-
dc.identifier.isiWOS:000961460600001-
dc.identifier.issnl2050-7771-

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