File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1111/dom.15173
- Scopus: eid_2-s2.0-85162977008
- WOS: WOS:001014857900001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Trajectories of fasting glucose and glycated haemoglobin in obese and non‐obese incident diabetes: Results from two large cohort studies
Title | Trajectories of fasting glucose and glycated haemoglobin in obese and non‐obese incident diabetes: Results from two large cohort studies |
---|---|
Authors | |
Keywords | body weight cohort study diabetes glycaemic trajectory |
Issue Date | 19-Jun-2023 |
Publisher | Wiley |
Citation | Diabetes, Obesity and Metabolism, 2023, v. 25, n. 10, p. 2835-2845 How to Cite? |
Abstract | AimsDiabetes development mechanisms vary by weight status. We aimed to compare cardiometabolic risk and characterize fasting plasma glucose (FPG) and glycated haemoglobin (HbA1c) trajectories before diagnosing type 2 diabetes in individuals with/without obesity. MethodsData from the China Health and Retirement Longitudinal Study (CHARLS) and English Longitudinal Study of Ageing (ELSA) were analysed. Participants without diabetes and with a body mass index of 18.5-40 kg/m2 at baseline were included. Incident diabetes was ascertained by self-reported physician diagnosis and/or antidiabetic drug use, FPG ≥126 mg/dl and/or HbA1c ≥6.5%. The difference in the FPG/HbA1c trajectory before the diabetes diagnosis in participants with/without obesity was examined using mixed-effects models. ResultsAmong 11 925 eligible participants, 1361 incident diabetes cases (mean age: 61.4 years; male: 46.2%) were identified within 15 years of follow-up. Obese diabetes showed higher levels of diastolic blood pressure and C-reactive protein at diagnosis than non-obese diabetes. Mixed-effects models indicated the difference in the FPG trajectory before diagnosis by weight status was non-significant with a slope difference of 0.149 mg/dl (SE = 0.642, p = .816, CHARLS) and 0.013 mg/dl (SE = 0.013, p = .337, ELSA). However, obese diabetes showed a steep increase in HbA1c before diagnosis with a slope difference of 0.036% (SE = 0.016, p = .021) in the CHARLS and 0.032% (SE = 0.014, p = .027) in the ELSA, respectively. Sex-stratified analyses showed that the difference in HbA1c trajectory before the diabetes diagnosis by weight status was only significant in males. ConclusionsObese and non-obese diabetes developments may share a similar FPG but distinct HbA1c trajectory. Obese diabetes interventions require more attention to cardiometabolic risks. Moreover, studies addressing weight/sex-related differences in diabetes aetiologies and treatments are warranted. |
Persistent Identifier | http://hdl.handle.net/10722/331710 |
ISSN | 2023 Impact Factor: 5.4 2023 SCImago Journal Rankings: 2.079 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Hongjie | - |
dc.contributor.author | Ho, Mandy | - |
dc.contributor.author | Chau, Pui Hing | - |
dc.contributor.author | Fong, Daniel Yee Tak | - |
dc.date.accessioned | 2023-09-21T06:58:13Z | - |
dc.date.available | 2023-09-21T06:58:13Z | - |
dc.date.issued | 2023-06-19 | - |
dc.identifier.citation | Diabetes, Obesity and Metabolism, 2023, v. 25, n. 10, p. 2835-2845 | - |
dc.identifier.issn | 1462-8902 | - |
dc.identifier.uri | http://hdl.handle.net/10722/331710 | - |
dc.description.abstract | <h3>Aims</h3><p>Diabetes development mechanisms vary by weight status. We aimed to compare cardiometabolic risk and characterize fasting plasma glucose (FPG) and glycated haemoglobin (HbA1c) trajectories before diagnosing type 2 diabetes in individuals with/without obesity.</p><h3>Methods</h3><p>Data from the China Health and Retirement Longitudinal Study (CHARLS) and English Longitudinal Study of Ageing (ELSA) were analysed. Participants without diabetes and with a body mass index of 18.5-40 kg/m<sup>2</sup> at baseline were included. Incident diabetes was ascertained by self-reported physician diagnosis and/or antidiabetic drug use, FPG ≥126 mg/dl and/or HbA1c ≥6.5%. The difference in the FPG/HbA1c trajectory before the diabetes diagnosis in participants with/without obesity was examined using mixed-effects models.</p><h3>Results</h3><p>Among 11 925 eligible participants, 1361 incident diabetes cases (mean age: 61.4 years; male: 46.2%) were identified within 15 years of follow-up. Obese diabetes showed higher levels of diastolic blood pressure and C-reactive protein at diagnosis than non-obese diabetes. Mixed-effects models indicated the difference in the FPG trajectory before diagnosis by weight status was non-significant with a slope difference of 0.149 mg/dl (SE = 0.642, <em>p</em> = .816, CHARLS) and 0.013 mg/dl (SE = 0.013, <em>p</em> = .337, ELSA). However, obese diabetes showed a steep increase in HbA1c before diagnosis with a slope difference of 0.036% (SE = 0.016, <em>p</em> = .021) in the CHARLS and 0.032% (SE = 0.014, <em>p</em> = .027) in the ELSA, respectively. Sex-stratified analyses showed that the difference in HbA1c trajectory before the diabetes diagnosis by weight status was only significant in males.</p><h3>Conclusions</h3><p>Obese and non-obese diabetes developments may share a similar FPG but distinct HbA1c trajectory. Obese diabetes interventions require more attention to cardiometabolic risks. Moreover, studies addressing weight/sex-related differences in diabetes aetiologies and treatments are warranted.</p> | - |
dc.language | eng | - |
dc.publisher | Wiley | - |
dc.relation.ispartof | Diabetes, Obesity and Metabolism | - |
dc.subject | body weight | - |
dc.subject | cohort study | - |
dc.subject | diabetes | - |
dc.subject | glycaemic trajectory | - |
dc.title | Trajectories of fasting glucose and glycated haemoglobin in obese and non‐obese incident diabetes: Results from two large cohort studies | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/dom.15173 | - |
dc.identifier.scopus | eid_2-s2.0-85162977008 | - |
dc.identifier.volume | 25 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 2835 | - |
dc.identifier.epage | 2845 | - |
dc.identifier.eissn | 1463-1326 | - |
dc.identifier.isi | WOS:001014857900001 | - |
dc.identifier.issnl | 1462-8902 | - |