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Article: Heat Shock Proteins in Non-Small-Cell Lung Cancer—Functional Mechanism

TitleHeat Shock Proteins in Non-Small-Cell Lung Cancer—Functional Mechanism
Authors
Keywordsapoptotic
Heat shock proteins
non-small cell lung cancer
Issue Date20-Mar-2023
PublisherIMR Press
Citation
Frontiers in Bioscience-Landmark, 2023, v. 28, n. 3 How to Cite?
Abstract

Non-small cell lung cancer (NSCLC) accounts for 80–85% of all lung cancers, which has the highest cancer-related mortality worldwide. Regardless of the therapeutic effects of chemotherapy or targeted therapy, drug resistance will occur after 1 year. Heat shock proteins (HSPs) are a class of molecular chaperones participated in protein stability and multiple intracellular signaling pathways. It has been widely reported that HSPs family is over expressed in non-small cell lung cancer, and these molecules are also associated with protein stability and multiple intracellular signaling pathways. The effect of chemotherapy drugs or targeted drugs on cancer cells is usually to induce apoptosis. It is necessary to explore the interaction between heat shock protein family and apoptosis pathway in NSCLC. Here we provide a brief review of how HSPs affect the apoptotic pathway in NSCLC.


Persistent Identifierhttp://hdl.handle.net/10722/331669
ISSN
2023 Impact Factor: 3.3
2023 SCImago Journal Rankings: 0.685
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Guanyu-
dc.contributor.authorPu, Yi-
dc.contributor.authorZhao, Kejia-
dc.contributor.authorChen, Yaohui-
dc.contributor.authorZhang, Gao-
dc.date.accessioned2023-09-21T06:57:51Z-
dc.date.available2023-09-21T06:57:51Z-
dc.date.issued2023-03-20-
dc.identifier.citationFrontiers in Bioscience-Landmark, 2023, v. 28, n. 3-
dc.identifier.issn2768-6701-
dc.identifier.urihttp://hdl.handle.net/10722/331669-
dc.description.abstract<p>Non-small cell lung cancer (NSCLC) accounts for 80–85% of all lung cancers, which has the highest cancer-related mortality worldwide. Regardless of the therapeutic effects of chemotherapy or targeted therapy, drug resistance will occur after 1 year. Heat shock proteins (HSPs) are a class of molecular chaperones participated in protein stability and multiple intracellular signaling pathways. It has been widely reported that HSPs family is over expressed in non-small cell lung cancer, and these molecules are also associated with protein stability and multiple intracellular signaling pathways. The effect of chemotherapy drugs or targeted drugs on cancer cells is usually to induce apoptosis. It is necessary to explore the interaction between heat shock protein family and apoptosis pathway in NSCLC. Here we provide a brief review of how HSPs affect the apoptotic pathway in NSCLC.<br></p>-
dc.languageeng-
dc.publisherIMR Press-
dc.relation.ispartofFrontiers in Bioscience-Landmark-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectapoptotic-
dc.subjectHeat shock proteins-
dc.subjectnon-small cell lung cancer-
dc.titleHeat Shock Proteins in Non-Small-Cell Lung Cancer—Functional Mechanism-
dc.typeArticle-
dc.identifier.doi10.31083/j.fbl2803056-
dc.identifier.scopuseid_2-s2.0-85151355721-
dc.identifier.volume28-
dc.identifier.issue3-
dc.identifier.eissn2768-6698-
dc.identifier.isiWOS:000970110000012-

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