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Article: Single-cell RNA sequencing highlights intratumor heterogeneity and intercellular network featured in adamantinomatous craniopharyngioma

TitleSingle-cell RNA sequencing highlights intratumor heterogeneity and intercellular network featured in adamantinomatous craniopharyngioma
Authors
Issue Date14-Apr-2023
PublisherAmerican Association for the Advancement of Science
Citation
Science Advances, 2023, v. 9, n. 15 How to Cite?
Abstract

Despite improvements in microscopically neurosurgical techniques made in recent years, the prognosis of adamantinomatous craniopharyngioma (ACP) is still unsatisfactory. Little is known about cellular atlas and biological features of ACP. Here, we carried out integrative analysis of 44,038 single-cell transcriptome profiles to characterize the landscape of intratumoral heterogeneity and tumor microenvironment (TME) in ACP. Four major neoplastic cell states with distinctive expression signatures were defined, which further revealed the histopathological features and elucidated unknown cellular atlas of ACP. Pseudotime analyses suggested potential evolutionary trajectories between specific neoplastic cell states. Notably, a distinct oligodendrocyte lineage was identified in ACP, which was associated with immunological infiltration and neural damage. In addition, we described a tumor-centric regulatory network based on intercellular communication in TME. Together, our findings represent a unique resource for deciphering tumor heterogeneity of ACP, which will improve clinical diagnosis and treatment strategies.


Persistent Identifierhttp://hdl.handle.net/10722/331668
ISSN
2023 Impact Factor: 11.7
2023 SCImago Journal Rankings: 4.483
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJiang, Y-
dc.contributor.authorYang, JL-
dc.contributor.authorLiang, RC-
dc.contributor.authorZan, X-
dc.contributor.authorFan, RR-
dc.contributor.authorShan, BY-
dc.contributor.authorLiu, H-
dc.contributor.authorLi, L-
dc.contributor.authorWang, Y-
dc.contributor.authorWu, M-
dc.contributor.authorQi, X-
dc.contributor.authorChen, HX-
dc.contributor.authorRen, QQ-
dc.contributor.authorLiu, ZY-
dc.contributor.authorWang, YL-
dc.contributor.authorZhang, J-
dc.contributor.authorZhou, PZ-
dc.contributor.authorLi, Q-
dc.contributor.authorTian, M-
dc.contributor.authorYang, JH-
dc.contributor.authorWang, CY-
dc.contributor.authorLi, XY-
dc.contributor.authorJiang, S-
dc.contributor.authorZhou, LX-
dc.contributor.authorZhang, G-
dc.contributor.authorChen, YH-
dc.contributor.authorXu, JG-
dc.date.accessioned2023-09-21T06:57:50Z-
dc.date.available2023-09-21T06:57:50Z-
dc.date.issued2023-04-14-
dc.identifier.citationScience Advances, 2023, v. 9, n. 15-
dc.identifier.issn2375-2548-
dc.identifier.urihttp://hdl.handle.net/10722/331668-
dc.description.abstract<p>Despite improvements in microscopically neurosurgical techniques made in recent years, the prognosis of adamantinomatous craniopharyngioma (ACP) is still unsatisfactory. Little is known about cellular atlas and biological features of ACP. Here, we carried out integrative analysis of 44,038 single-cell transcriptome profiles to characterize the landscape of intratumoral heterogeneity and tumor microenvironment (TME) in ACP. Four major neoplastic cell states with distinctive expression signatures were defined, which further revealed the histopathological features and elucidated unknown cellular atlas of ACP. Pseudotime analyses suggested potential evolutionary trajectories between specific neoplastic cell states. Notably, a distinct oligodendrocyte lineage was identified in ACP, which was associated with immunological infiltration and neural damage. In addition, we described a tumor-centric regulatory network based on intercellular communication in TME. Together, our findings represent a unique resource for deciphering tumor heterogeneity of ACP, which will improve clinical diagnosis and treatment strategies.</p>-
dc.languageeng-
dc.publisherAmerican Association for the Advancement of Science-
dc.relation.ispartofScience Advances-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSingle-cell RNA sequencing highlights intratumor heterogeneity and intercellular network featured in adamantinomatous craniopharyngioma-
dc.typeArticle-
dc.identifier.doi10.1126/sciadv.adc8933-
dc.identifier.scopuseid_2-s2.0-85152343455-
dc.identifier.volume9-
dc.identifier.issue15-
dc.identifier.eissn2375-2548-
dc.identifier.isiWOS:000980467100007-
dc.identifier.issnl2375-2548-

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