File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: T-cell phenotype including CD57+ T follicular helper cells in the tumor microenvironment correlate with a poor outcome in follicular lymphoma

TitleT-cell phenotype including CD57+ T follicular helper cells in the tumor microenvironment correlate with a poor outcome in follicular lymphoma
Authors
Issue Date18-Aug-2023
PublisherSpringer Nature [academic journals on nature.com]
Citation
Blood Cancer Journal, 2023, v. 13, n. 1 How to Cite?
Abstract

T-lymphocytes are prevalent in the tumor microenvironment of follicular lymphoma (FL). However, the phenotype of T-cells may vary, and the prevalence of certain T-cell subsets may influence tumor biology and patient survival. We therefore analyzed a cohort of 82 FL patients using CyTOF to determine whether specific T-cell phenotypes were associated with distinct tumor microenvironments and patient outcome. We identified four immune subgroups with differing T-cell phenotypes and the prevalence of certain T-cell subsets was associated with patient survival. Patients with increased T cells with early differentiation stage tended to have a significantly better survival than patients with increased T-cells of late differentiation stage. Specifically, CD57(+) T-FH cells, with a late-stage differentiation phenotype, were significantly more abundant in FL patients who had early disease progression and therefore correlated with an inferior survival. Single cell analysis (CITE-seq) revealed that CD57(+) T-FH cells exhibited a substantially different transcriptome from CD57(-) T-FH cells with upregulation of inflammatory pathways, evidence of immune exhaustion and susceptibility to apoptosis. Taken together, our results show that different tumor microenvironments among FL patients are associated with variable T-cell phenotypes and an increased prevalence of CD57(+) T-FH cells is associated with poor patient survival.


Persistent Identifierhttp://hdl.handle.net/10722/331526
ISSN
2023 Impact Factor: 12.9
2023 SCImago Journal Rankings: 3.974
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYang, ZZ-
dc.contributor.authorKim, HJ-
dc.contributor.authorWu, HY-
dc.contributor.authorTang, XY-
dc.contributor.authorYu, Y-
dc.contributor.authorKrull, J-
dc.contributor.authorLarson, DP-
dc.contributor.authorMoore, RM-
dc.contributor.authorMaurer, MJ-
dc.contributor.authorPavelko, KD-
dc.contributor.authorJalali, S-
dc.contributor.authorPritchett, JC-
dc.contributor.authorMudappathi, R-
dc.contributor.authorWang, JW-
dc.contributor.authorVillasboas, JC-
dc.contributor.authorMondello, P-
dc.contributor.authorNovak, AJ-
dc.contributor.authorAnsell, SM-
dc.date.accessioned2023-09-21T06:56:38Z-
dc.date.available2023-09-21T06:56:38Z-
dc.date.issued2023-08-18-
dc.identifier.citationBlood Cancer Journal, 2023, v. 13, n. 1-
dc.identifier.issn2044-5385-
dc.identifier.urihttp://hdl.handle.net/10722/331526-
dc.description.abstract<p></p><p>T-lymphocytes are prevalent in the tumor microenvironment of follicular lymphoma (FL). However, the phenotype of T-cells may vary, and the prevalence of certain T-cell subsets may influence tumor biology and patient survival. We therefore analyzed a cohort of 82 FL patients using CyTOF to determine whether specific T-cell phenotypes were associated with distinct tumor microenvironments and patient outcome. We identified four immune subgroups with differing T-cell phenotypes and the prevalence of certain T-cell subsets was associated with patient survival. Patients with increased T cells with early differentiation stage tended to have a significantly better survival than patients with increased T-cells of late differentiation stage. Specifically, CD57(+) T-FH cells, with a late-stage differentiation phenotype, were significantly more abundant in FL patients who had early disease progression and therefore correlated with an inferior survival. Single cell analysis (CITE-seq) revealed that CD57(+) T-FH cells exhibited a substantially different transcriptome from CD57(-) T-FH cells with upregulation of inflammatory pathways, evidence of immune exhaustion and susceptibility to apoptosis. Taken together, our results show that different tumor microenvironments among FL patients are associated with variable T-cell phenotypes and an increased prevalence of CD57(+) T-FH cells is associated with poor patient survival.<br></p>-
dc.languageeng-
dc.publisherSpringer Nature [academic journals on nature.com]-
dc.relation.ispartofBlood Cancer Journal-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleT-cell phenotype including CD57+ T follicular helper cells in the tumor microenvironment correlate with a poor outcome in follicular lymphoma-
dc.typeArticle-
dc.identifier.doi10.1038/s41408-023-00899-3-
dc.identifier.scopuseid_2-s2.0-85168295634-
dc.identifier.volume13-
dc.identifier.issue1-
dc.identifier.eissn2044-5385-
dc.identifier.isiWOS:001050469000004-
dc.identifier.issnl2044-5385-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats