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- Publisher Website: 10.1016/j.yexcr.2023.113599
- Scopus: eid_2-s2.0-85152436810
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Article: Ex vivo expansion of hematopoietic stem cells
Title | Ex vivo expansion of hematopoietic stem cells |
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Authors | |
Keywords | Ex vivo Expansion HSC polymers Small molecules Transplantation |
Issue Date | 1-Jun-2023 |
Publisher | Elsevier |
Citation | Experimental Cell Research, 2023, v. 427, n. 1 How to Cite? |
Abstract | Hematopoietic stem cells (HSCs) are multipotent progenitor cells that can differentiate into various mature blood cells and immune cells, thus reconstituting hematopoiesis. By taking advantage of the tremendous potential of HSCs, varied hereditary and hematologic diseases are promised to be alleviated or cured. To solve the contradiction between the growing demand for HSCs in disease treatment and the low population of HSCs in both cord blood and bone marrow, ex vivo HSC expansion along with multiple protocols has been investigated for harvesting adequate HSCs over the past two decades. This review surveys the state-of-the-art techniques for ex vivo HSC self-renewal and provides a concise summary of the effects of diverse intrinsic and extrinsic factors on the expansion of HSCs. The remaining challenges and emerging opportunities in the field of HSC expansion are also presented. |
Persistent Identifier | http://hdl.handle.net/10722/331438 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 0.947 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, Yuan | - |
dc.contributor.author | Sugimura, Ryohichi | - |
dc.date.accessioned | 2023-09-21T06:55:44Z | - |
dc.date.available | 2023-09-21T06:55:44Z | - |
dc.date.issued | 2023-06-01 | - |
dc.identifier.citation | Experimental Cell Research, 2023, v. 427, n. 1 | - |
dc.identifier.issn | 0014-4827 | - |
dc.identifier.uri | http://hdl.handle.net/10722/331438 | - |
dc.description.abstract | <p> Hematopoietic stem cells (HSCs) are multipotent progenitor cells that can differentiate into various mature blood cells and immune cells, thus reconstituting hematopoiesis. By taking advantage of the tremendous potential of HSCs, varied hereditary and hematologic diseases are promised to be alleviated or cured. To solve the contradiction between the growing demand for HSCs in disease treatment and the low population of HSCs in both cord blood and bone marrow, ex vivo HSC expansion along with multiple protocols has been investigated for harvesting adequate HSCs over the past two decades. This review surveys the state-of-the-art techniques for ex vivo HSC self-renewal and provides a concise summary of the effects of diverse intrinsic and extrinsic factors on the expansion of HSCs. The remaining challenges and emerging opportunities in the field of HSC expansion are also presented. <br></p> | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | Experimental Cell Research | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Ex vivo | - |
dc.subject | Expansion | - |
dc.subject | HSC | - |
dc.subject | polymers | - |
dc.subject | Small molecules | - |
dc.subject | Transplantation | - |
dc.title | Ex vivo expansion of hematopoietic stem cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.yexcr.2023.113599 | - |
dc.identifier.scopus | eid_2-s2.0-85152436810 | - |
dc.identifier.volume | 427 | - |
dc.identifier.issue | 1 | - |
dc.identifier.isi | WOS:000984579800001 | - |
dc.identifier.issnl | 0014-4827 | - |