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Article: Effectiveness of BNT162b2 and CoronaVac in children and adolescents against SARS-CoV-2 infection during Omicron BA.2 wave in Hong Kong

TitleEffectiveness of BNT162b2 and CoronaVac in children and adolescents against SARS-CoV-2 infection during Omicron BA.2 wave in Hong Kong
Authors
Issue Date5-Jan-2023
PublisherNature Portfolio
Citation
Communications Medicine, 2023, v. 3 How to Cite?
Abstract

Background

The SARS-CoV-2 Omicron BA.2 subvariant replaced BA.1 globally in early 2022, and caused an unprecedented tsunami of cases in Hong Kong, resulting in the collapse of elimination strategy. Vaccine effectiveness (VE) of BNT162b2 and CoronaVac against BA.2 is unclear.

Methods

We utilize an ecological design incorporating population-level vaccine coverage statistics and territory-wide case-level SARS-CoV-2 infection surveillance data, and investigate the VE against infection during the Omicron BA.2 wave between January 1 to April 19, 2022, in Hong Kong for children and adolescents.

Results

We estimate VE to be 33.0% for 1 dose of BNT162b2 in children aged 5–11 and 40.8% for 2 doses of CoronaVac in children aged 3–11. We also estimate 54.9% VE for 2 doses of BNT162b2, and 55.0% VE for 2 doses of CoronaVac in adolescents aged 12–18.

Conclusions

Our findings support partly preserved VE against infection by variants of concerns for children and adolescents in settings with extremely low levels of prior SARS-CoV-2 circulation.


Persistent Identifierhttp://hdl.handle.net/10722/331431
ISSN
2023 Impact Factor: 5.4

 

DC FieldValueLanguage
dc.contributor.authorLeung, D-
dc.contributor.authorDuque, JSR-
dc.contributor.authorYip, KM-
dc.contributor.authorSo, HK-
dc.contributor.authorWong, WHS-
dc.contributor.authorLau, YL-
dc.date.accessioned2023-09-21T06:55:39Z-
dc.date.available2023-09-21T06:55:39Z-
dc.date.issued2023-01-05-
dc.identifier.citationCommunications Medicine, 2023, v. 3-
dc.identifier.issn2730-664X-
dc.identifier.urihttp://hdl.handle.net/10722/331431-
dc.description.abstract<h3>Background</h3><p>The SARS-CoV-2 Omicron BA.2 subvariant replaced BA.1 globally in early 2022, and caused an unprecedented tsunami of cases in Hong Kong, resulting in the collapse of elimination strategy. Vaccine effectiveness (VE) of BNT162b2 and CoronaVac against BA.2 is unclear.</p><h3>Methods</h3><p>We utilize an ecological design incorporating population-level vaccine coverage statistics and territory-wide case-level SARS-CoV-2 infection surveillance data, and investigate the VE against infection during the Omicron BA.2 wave between January 1 to April 19, 2022, in Hong Kong for children and adolescents.</p><h3>Results</h3><p>We estimate VE to be 33.0% for 1 dose of BNT162b2 in children aged 5–11 and 40.8% for 2 doses of CoronaVac in children aged 3–11. We also estimate 54.9% VE for 2 doses of BNT162b2, and 55.0% VE for 2 doses of CoronaVac in adolescents aged 12–18.</p><h3>Conclusions</h3><p>Our findings support partly preserved VE against infection by variants of concerns for children and adolescents in settings with extremely low levels of prior SARS-CoV-2 circulation.</p>-
dc.languageeng-
dc.publisherNature Portfolio-
dc.relation.ispartofCommunications Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleEffectiveness of BNT162b2 and CoronaVac in children and adolescents against SARS-CoV-2 infection during Omicron BA.2 wave in Hong Kong-
dc.typeArticle-
dc.identifier.doi10.1038/s43856-022-00233-1-
dc.identifier.volume3-
dc.identifier.eissn2730-664X-
dc.identifier.issnl2730-664X-

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