File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Hippocampus Modulates Vocalizations Responses at Early Auditory Centers

TitleHippocampus Modulates Vocalizations Responses at Early Auditory Centers
Authors
KeywordsAuditory cortex
Auditory system
fMRI
Hippocampus
Inferior colliculus
Medial geniculate body
Optogenetics
Vocalizations
Issue Date15-Apr-2023
PublisherElsevier
Citation
NeuroImage, 2023, v. 270 How to Cite?
AbstractDespite its prominence in learning and memory, hippocampal influence in early auditory processing centers re-mains unknown. Here, we examined how hippocampal activity modulates sound-evoked responses in the auditory midbrain and thalamus using optogenetics and functional MRI (fMRI) in rodents. Ventral hippocampus (vHP) ex-citatory neuron stimulation at 5 Hz evoked robust hippocampal activity that propagates to the primary auditory cortex. We then tested 5 Hz vHP stimulation paired with either natural vocalizations or artificial/noise acoustic stimuli. vHP stimulation enhanced auditory responses to vocalizations (with a negative or positive valence) in the inferior colliculus, medial geniculate body, and auditory cortex, but not to their temporally reversed counter-parts (artificial sounds) or broadband noise. Meanwhile, pharmacological vHP inactivation diminished response selectivity to vocalizations. These results directly reveal the large-scale hippocampal participation in natural sound processing at early centers of the ascending auditory pathway. They expand our present understanding of hippocampus in global auditory networks.
Persistent Identifierhttp://hdl.handle.net/10722/331418
ISSN
2023 Impact Factor: 4.7
2023 SCImago Journal Rankings: 2.436
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeong, ATL-
dc.contributor.authorWong, EC-
dc.contributor.authorWang, XD-
dc.contributor.authorWu, EX-
dc.date.accessioned2023-09-21T06:55:31Z-
dc.date.available2023-09-21T06:55:31Z-
dc.date.issued2023-04-15-
dc.identifier.citationNeuroImage, 2023, v. 270-
dc.identifier.issn1053-8119-
dc.identifier.urihttp://hdl.handle.net/10722/331418-
dc.description.abstractDespite its prominence in learning and memory, hippocampal influence in early auditory processing centers re-mains unknown. Here, we examined how hippocampal activity modulates sound-evoked responses in the auditory midbrain and thalamus using optogenetics and functional MRI (fMRI) in rodents. Ventral hippocampus (vHP) ex-citatory neuron stimulation at 5 Hz evoked robust hippocampal activity that propagates to the primary auditory cortex. We then tested 5 Hz vHP stimulation paired with either natural vocalizations or artificial/noise acoustic stimuli. vHP stimulation enhanced auditory responses to vocalizations (with a negative or positive valence) in the inferior colliculus, medial geniculate body, and auditory cortex, but not to their temporally reversed counter-parts (artificial sounds) or broadband noise. Meanwhile, pharmacological vHP inactivation diminished response selectivity to vocalizations. These results directly reveal the large-scale hippocampal participation in natural sound processing at early centers of the ascending auditory pathway. They expand our present understanding of hippocampus in global auditory networks.-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofNeuroImage-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAuditory cortex-
dc.subjectAuditory system-
dc.subjectfMRI-
dc.subjectHippocampus-
dc.subjectInferior colliculus-
dc.subjectMedial geniculate body-
dc.subjectOptogenetics-
dc.subjectVocalizations-
dc.titleHippocampus Modulates Vocalizations Responses at Early Auditory Centers-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.neuroimage.2023.119943-
dc.identifier.pmid36828157-
dc.identifier.scopuseid_2-s2.0-85149178441-
dc.identifier.volume270-
dc.identifier.eissn1095-9572-
dc.identifier.isiWOS:000949824100001-
dc.publisher.placeSAN DIEGO-
dc.identifier.issnl1053-8119-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats