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Article: Functional MRI reveals brain-wide actions of thalamically-initiated oscillatory activities on associative memory consolidation

TitleFunctional MRI reveals brain-wide actions of thalamically-initiated oscillatory activities on associative memory consolidation
Authors
Issue Date17-Apr-2023
PublisherNature Research
Citation
Nature Communications, 2023, v. 14, n. 1 How to Cite?
Abstract

Thalamic spindle activities may support memory consolidation. Here the authors show that optogenetically-evoked somatosensory thalamic spindle-like activity enhances memory performance in male rats.As a key oscillatory activity in the brain, thalamic spindle activities are long believed to support memory consolidation. However, their propagation characteristics and causal actions at systems level remain unclear. Using functional MRI (fMRI) and electrophysiology recordings in male rats, we found that optogenetically-evoked somatosensory thalamic spindle-like activities targeted numerous sensorimotor (cortex, thalamus, brainstem and basal ganglia) and non-sensorimotor limbic regions (cortex, amygdala, and hippocampus) in a stimulation frequency- and length-dependent manner. Thalamic stimulation at slow spindle frequency (8 Hz) and long spindle length (3 s) evoked the most robust brain-wide cross-modal activities. Behaviorally, evoking these global cross-modal activities during memory consolidation improved visual-somatosensory associative memory performance. More importantly, parallel visual fMRI experiments uncovered response potentiation in brain-wide sensorimotor and limbic integrative regions, especially superior colliculus, periaqueductal gray, and insular, retrosplenial and frontal cortices. Our study directly reveals that thalamic spindle activities propagate in a spatiotemporally specific manner and that they consolidate associative memory by strengthening multi-target memory representation.


Persistent Identifierhttp://hdl.handle.net/10722/331417
ISSN
2023 Impact Factor: 14.7
2023 SCImago Journal Rankings: 4.887
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, XD-
dc.contributor.authorLeong, ATL-
dc.contributor.authorTan, SZK-
dc.contributor.authorWong, EC-
dc.contributor.authorLiu, YL-
dc.contributor.authorLim, LW-
dc.contributor.authorWu, EX-
dc.date.accessioned2023-09-21T06:55:31Z-
dc.date.available2023-09-21T06:55:31Z-
dc.date.issued2023-04-17-
dc.identifier.citationNature Communications, 2023, v. 14, n. 1-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/331417-
dc.description.abstract<p>Thalamic spindle activities may support memory consolidation. Here the authors show that optogenetically-evoked somatosensory thalamic spindle-like activity enhances memory performance in male rats.As a key oscillatory activity in the brain, thalamic spindle activities are long believed to support memory consolidation. However, their propagation characteristics and causal actions at systems level remain unclear. Using functional MRI (fMRI) and electrophysiology recordings in male rats, we found that optogenetically-evoked somatosensory thalamic spindle-like activities targeted numerous sensorimotor (cortex, thalamus, brainstem and basal ganglia) and non-sensorimotor limbic regions (cortex, amygdala, and hippocampus) in a stimulation frequency- and length-dependent manner. Thalamic stimulation at slow spindle frequency (8 Hz) and long spindle length (3 s) evoked the most robust brain-wide cross-modal activities. Behaviorally, evoking these global cross-modal activities during memory consolidation improved visual-somatosensory associative memory performance. More importantly, parallel visual fMRI experiments uncovered response potentiation in brain-wide sensorimotor and limbic integrative regions, especially superior colliculus, periaqueductal gray, and insular, retrosplenial and frontal cortices. Our study directly reveals that thalamic spindle activities propagate in a spatiotemporally specific manner and that they consolidate associative memory by strengthening multi-target memory representation.</p>-
dc.languageeng-
dc.publisherNature Research-
dc.relation.ispartofNature Communications-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleFunctional MRI reveals brain-wide actions of thalamically-initiated oscillatory activities on associative memory consolidation-
dc.typeArticle-
dc.identifier.doi10.1038/s41467-023-37682-8-
dc.identifier.pmid37069169-
dc.identifier.scopuseid_2-s2.0-85152654639-
dc.identifier.volume14-
dc.identifier.issue1-
dc.identifier.eissn2041-1723-
dc.identifier.isiWOS:001013529900017-
dc.publisher.placeBERLIN-
dc.identifier.issnl2041-1723-

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