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Article: Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children
Title | Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children |
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Authors | Bucciol, GiorgiaMeyts, IsabelleAbel, LaurentAl-Muhsen, SalahAiuti, AlessandroAl-Mulla, FahdAndreakos, EvangelosAntonio, NovelliArias, Andrés ATrouillet-Assant, SophieBelot, AlexandreBiggs, Catherine MBousfiha, Ahmed ABolze, AlexBorghesi, AlessandroBrodin, PetterChristodoulou, JohnCobat, AurélieCondino-Neto, AntonioConstantinescu, StefanDalgard, Clifton LEspinosa-Padilla, SaraFellay, JacquesFlores, CarlosFranco, José LuisFroidure, AntoineGorochov, GuyHaerynck, FilomeenHalwani, RabihHsieh, Elena WYItan, YuvalKisand, KaiLau, Yu-Lunget al |
Keywords | COVID-19 multisystem inflammatory syndrome in children SARS-CoV-2 type I interferon |
Issue Date | 1-Apr-2023 |
Publisher | Elsevier |
Citation | Journal of Allergy and Clinical Immunology, 2023, v. 151, n. 4, p. 832-840 How to Cite? |
Abstract | Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/coronavirus disease 2019 (COVID-19) pandemic, global sequencing efforts have led in the field of inborn errors of immunity, and inspired particularly by previous research on life-threatening influenza, they have revealed that known and novel inborn errors affecting type I interferon immunity underlie critical COVID-19 in up to 5% of cases. In addition, neutralizing autoantibodies against type I interferons have been identified in up to 20% of patients with critical COVID-19 who are older than 80 years and 20% of fatal cases, with a higher prevalence in men and individuals older than 70 years. Also, inborn errors impairing regulation of type I interferon responses and RNA degradation have been found as causes of multisystem inflammatory syndrome in children, a life-threatening hyperinflammatory condition complicating otherwise mild initial SARS-CoV-2 infection in children and young adults. Better understanding of these immunologic mechanisms can aid in designing treatments for severe COVID-19, multisystem inflammatory syndrome in children, long COVID, and neuro-COVID. (J Allergy Clin Immunol 2023;151:832-40.) |
Persistent Identifier | http://hdl.handle.net/10722/331406 |
ISSN | 2023 Impact Factor: 11.4 2023 SCImago Journal Rankings: 3.701 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Bucciol, Giorgia | - |
dc.contributor.author | Meyts, Isabelle | - |
dc.contributor.author | Abel, Laurent | - |
dc.contributor.author | Al-Muhsen, Salah | - |
dc.contributor.author | Aiuti, Alessandro | - |
dc.contributor.author | Al-Mulla, Fahd | - |
dc.contributor.author | Andreakos, Evangelos | - |
dc.contributor.author | Antonio, Novelli | - |
dc.contributor.author | Arias, Andrés A | - |
dc.contributor.author | Trouillet-Assant, Sophie | - |
dc.contributor.author | Belot, Alexandre | - |
dc.contributor.author | Biggs, Catherine M | - |
dc.contributor.author | Bousfiha, Ahmed A | - |
dc.contributor.author | Bolze, Alex | - |
dc.contributor.author | Borghesi, Alessandro | - |
dc.contributor.author | Brodin, Petter | - |
dc.contributor.author | Christodoulou, John | - |
dc.contributor.author | Cobat, Aurélie | - |
dc.contributor.author | Condino-Neto, Antonio | - |
dc.contributor.author | Constantinescu, Stefan | - |
dc.contributor.author | Dalgard, Clifton L | - |
dc.contributor.author | Espinosa-Padilla, Sara | - |
dc.contributor.author | Fellay, Jacques | - |
dc.contributor.author | Flores, Carlos | - |
dc.contributor.author | Franco, José Luis | - |
dc.contributor.author | Froidure, Antoine | - |
dc.contributor.author | Gorochov, Guy | - |
dc.contributor.author | Haerynck, Filomeen | - |
dc.contributor.author | Halwani, Rabih | - |
dc.contributor.author | Hsieh, Elena WY | - |
dc.contributor.author | Itan, Yuval | - |
dc.contributor.author | Kisand, Kai | - |
dc.contributor.author | Lau, Yu-Lung | - |
dc.contributor.author | et al | - |
dc.date.accessioned | 2023-09-21T06:55:25Z | - |
dc.date.available | 2023-09-21T06:55:25Z | - |
dc.date.issued | 2023-04-01 | - |
dc.identifier.citation | Journal of Allergy and Clinical Immunology, 2023, v. 151, n. 4, p. 832-840 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.uri | http://hdl.handle.net/10722/331406 | - |
dc.description.abstract | <p></p><p>Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/coronavirus disease 2019 (COVID-19) pandemic, global sequencing efforts have led in the field of inborn errors of immunity, and inspired particularly by previous research on life-threatening influenza, they have revealed that known and novel inborn errors affecting type I interferon immunity underlie critical COVID-19 in up to 5% of cases. In addition, neutralizing autoantibodies against type I interferons have been identified in up to 20% of patients with critical COVID-19 who are older than 80 years and 20% of fatal cases, with a higher prevalence in men and individuals older than 70 years. Also, inborn errors impairing regulation of type I interferon responses and RNA degradation have been found as causes of multisystem inflammatory syndrome in children, a life-threatening hyperinflammatory condition complicating otherwise mild initial SARS-CoV-2 infection in children and young adults. Better understanding of these immunologic mechanisms can aid in designing treatments for severe COVID-19, multisystem inflammatory syndrome in children, long COVID, and neuro-COVID. (J Allergy Clin Immunol 2023;151:832-40.)<br></p> | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | Journal of Allergy and Clinical Immunology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | COVID-19 | - |
dc.subject | multisystem inflammatory syndrome in children | - |
dc.subject | SARS-CoV-2 | - |
dc.subject | type I interferon | - |
dc.title | Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jaci.2023.02.003 | - |
dc.identifier.scopus | eid_2-s2.0-85149863960 | - |
dc.identifier.volume | 151 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 832 | - |
dc.identifier.epage | 840 | - |
dc.identifier.isi | WOS:000982200500001 | - |
dc.identifier.issnl | 0091-6749 | - |