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Article: Organoid cultures for cancer modeling.

TitleOrganoid cultures for cancer modeling.
Authors
Keywordscancer
organoids
Issue Date6-Jul-2023
PublisherElsevier
Citation
Cell Stem Cell, 2023, v. 30, n. 7, p. 917-937 How to Cite?
AbstractOrganoids derived from adult stem cells (ASCs) and pluripotent stem cells (PSCs) are important preclinical models for studying cancer and developing therapies. Here, we review primary tissue-derived and PSC-derived cancer organoid models and detail how they have the potential to inform personalized medical approaches in different organ contexts and contribute to the understanding of early carcinogenic steps, cancer genomes, and biology. We also compare the differences between ASC- and PSC-based cancer organoid systems, discuss their limitations, and highlight recent improvements to organoid culture approaches that have helped to make them an even better representation of human tumors.
Persistent Identifierhttp://hdl.handle.net/10722/331403
ISSN
2023 Impact Factor: 19.8
2023 SCImago Journal Rankings: 10.253
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYan, HHN-
dc.contributor.authorChan, AS-
dc.contributor.authorLai, FP-
dc.contributor.authorLeung, SY-
dc.date.accessioned2023-09-21T06:55:24Z-
dc.date.available2023-09-21T06:55:24Z-
dc.date.issued2023-07-06-
dc.identifier.citationCell Stem Cell, 2023, v. 30, n. 7, p. 917-937-
dc.identifier.issn1934-5909-
dc.identifier.urihttp://hdl.handle.net/10722/331403-
dc.description.abstractOrganoids derived from adult stem cells (ASCs) and pluripotent stem cells (PSCs) are important preclinical models for studying cancer and developing therapies. Here, we review primary tissue-derived and PSC-derived cancer organoid models and detail how they have the potential to inform personalized medical approaches in different organ contexts and contribute to the understanding of early carcinogenic steps, cancer genomes, and biology. We also compare the differences between ASC- and PSC-based cancer organoid systems, discuss their limitations, and highlight recent improvements to organoid culture approaches that have helped to make them an even better representation of human tumors.-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofCell Stem Cell-
dc.subjectcancer-
dc.subjectorganoids-
dc.titleOrganoid cultures for cancer modeling.-
dc.typeArticle-
dc.identifier.doi10.1016/j.stem.2023.05.012-
dc.identifier.pmid37315564-
dc.identifier.scopuseid_2-s2.0-85163852558-
dc.identifier.volume30-
dc.identifier.issue7-
dc.identifier.spage917-
dc.identifier.epage937-
dc.identifier.eissn1875-9777-
dc.identifier.isiWOS:001042019200001-
dc.identifier.issnl1875-9777-

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