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Article: Recent progress on the chemical synthesis of bacterial non-2-ulosonic acids

TitleRecent progress on the chemical synthesis of bacterial non-2-ulosonic acids
Authors
Issue Date2-Jun-2023
PublisherRoyal Society of Chemistry
Citation
Organic Chemistry Frontiers, 2023, v. 10, n. 13, p. 3429-3446 How to Cite?
Abstract

Bacteria resistant to antibiotics present a threat to public health. The bacterial non-2-ulosonic acids, including pseudaminic acid, legionaminic acid, acinetaminic acid, fusaminic acid, and several of their epimers, have been identified from the pathogenic Gram-negative bacteria, which have been proposed to associate with bacterial infection/pathogenicity, immune escape, and so on. The intriguing structures and less-understood biological functions make them attractive synthetic targets for biological studies and drug discovery. In this review, the chemical syntheses of four types of non-2-ulosonic acid structures that were reported in the past two decades are summarised, together with recent progress on the application of synthetic non-2-ulosonic acid derivatives.


Persistent Identifierhttp://hdl.handle.net/10722/331197
ISSN
2023 SCImago Journal Rankings: 1.016
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGuo, X-
dc.contributor.authorLi, PF-
dc.contributor.authorLiu, H-
dc.contributor.authorLi, XC-
dc.date.accessioned2023-09-21T06:53:37Z-
dc.date.available2023-09-21T06:53:37Z-
dc.date.issued2023-06-02-
dc.identifier.citationOrganic Chemistry Frontiers, 2023, v. 10, n. 13, p. 3429-3446-
dc.identifier.issn2052-4110-
dc.identifier.urihttp://hdl.handle.net/10722/331197-
dc.description.abstract<p>Bacteria resistant to antibiotics present a threat to public health. The bacterial non-2-ulosonic acids, including pseudaminic acid, legionaminic acid, acinetaminic acid, fusaminic acid, and several of their epimers, have been identified from the pathogenic Gram-negative bacteria, which have been proposed to associate with bacterial infection/pathogenicity, immune escape, and so on. The intriguing structures and less-understood biological functions make them attractive synthetic targets for biological studies and drug discovery. In this review, the chemical syntheses of four types of non-2-ulosonic acid structures that were reported in the past two decades are summarised, together with recent progress on the application of synthetic non-2-ulosonic acid derivatives.</p>-
dc.languageeng-
dc.publisherRoyal Society of Chemistry-
dc.relation.ispartofOrganic Chemistry Frontiers-
dc.titleRecent progress on the chemical synthesis of bacterial non-2-ulosonic acids-
dc.typeArticle-
dc.identifier.doi10.1039/D3QO00637A-
dc.identifier.scopuseid_2-s2.0-85163410768-
dc.identifier.volume10-
dc.identifier.issue13-
dc.identifier.spage3429-
dc.identifier.epage3446-
dc.identifier.eissn2052-4129-
dc.identifier.isiWOS:001006241900001-
dc.identifier.issnl2052-4110-

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