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- Publisher Website: 10.1016/j.chom.2023.05.017
- Scopus: eid_2-s2.0-85161258169
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Article: Broad-spectrum pan-genus and pan-family virus vaccines
Title | Broad-spectrum pan-genus and pan-family virus vaccines |
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Authors | |
Keywords | antibody vaccine broad-spectrum vaccine disease X passive immunization ring vaccination universal vaccine |
Issue Date | 14-Jun-2023 |
Publisher | Cell Press |
Citation | Cell Host & Microbe, 2023, v. 31, n. 6, p. 902-916 How to Cite? |
Abstract | Although the development and clinical application of SARS-CoV-2 vaccines during the COVID-19 pandemic demonstrated unprecedented vaccine success in a short time frame, it also revealed a limitation of current vaccines in their inability to provide broad-spectrum or universal protection against emerging variants. Broad-spectrum vaccines, therefore, remain a dream and challenge for vaccinology. This review will focus on current and future efforts in developing universal vaccines targeting different viruses at the genus and/or family levels, with a special focus on henipaviruses, influenza viruses, and coronaviruses. It is evident that strategies for developing broad-spectrum vaccines will be virus-genus or family specific, and it is almost impossible to adopt a universal approach for different viruses. On the other hand, efforts in developing broad-spectrum neutralizing monoclonal antibodies have been more successful and it is worth considering broad-spectrum antibody-mediated immunization, or “universal antibody vaccine,” as an alternative approach for early intervention for future disease X outbreaks. |
Persistent Identifier | http://hdl.handle.net/10722/330980 |
ISSN | 2023 Impact Factor: 20.6 2023 SCImago Journal Rankings: 7.760 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tan, Chee Wah | - |
dc.contributor.author | Valkenburg, Sophie | - |
dc.contributor.author | Poon, Leo Lit Man | - |
dc.contributor.author | Wang, Lin Fa | - |
dc.date.accessioned | 2023-09-21T06:51:44Z | - |
dc.date.available | 2023-09-21T06:51:44Z | - |
dc.date.issued | 2023-06-14 | - |
dc.identifier.citation | Cell Host & Microbe, 2023, v. 31, n. 6, p. 902-916 | - |
dc.identifier.issn | 1931-3128 | - |
dc.identifier.uri | http://hdl.handle.net/10722/330980 | - |
dc.description.abstract | <p>Although the development and clinical application of SARS-CoV-2 vaccines during the COVID-19 pandemic demonstrated unprecedented vaccine success in a short time frame, it also revealed a limitation of current vaccines in their inability to provide broad-spectrum or universal protection against emerging variants. Broad-spectrum vaccines, therefore, remain a dream and challenge for vaccinology. This review will focus on current and future efforts in developing universal vaccines targeting different viruses at the genus and/or family levels, with a special focus on henipaviruses, influenza viruses, and coronaviruses. It is evident that strategies for developing broad-spectrum vaccines will be virus-genus or family specific, and it is almost impossible to adopt a universal approach for different viruses. On the other hand, efforts in developing broad-spectrum neutralizing monoclonal antibodies have been more successful and it is worth considering broad-spectrum antibody-mediated immunization, or “universal antibody vaccine,” as an alternative approach for early intervention for future disease X outbreaks.</p> | - |
dc.language | eng | - |
dc.publisher | Cell Press | - |
dc.relation.ispartof | Cell Host & Microbe | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | antibody vaccine | - |
dc.subject | broad-spectrum vaccine | - |
dc.subject | disease X | - |
dc.subject | passive immunization | - |
dc.subject | ring vaccination | - |
dc.subject | universal vaccine | - |
dc.title | Broad-spectrum pan-genus and pan-family virus vaccines | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.chom.2023.05.017 | - |
dc.identifier.scopus | eid_2-s2.0-85161258169 | - |
dc.identifier.volume | 31 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 902 | - |
dc.identifier.epage | 916 | - |
dc.identifier.eissn | 1934-6069 | - |
dc.identifier.isi | WOS:001027877600001 | - |
dc.identifier.issnl | 1931-3128 | - |