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Article: HSC-independent definitive hematopoiesis persists into adult life

TitleHSC-independent definitive hematopoiesis persists into adult life
Authors
Keywordsadaptive immune lymphocytes
AGM region
B-1a cells
CP: Developmental biology
hemogenic endothelial cells
HSC precursors
HSC-independent hematopoiesis
lineage tracing mouse models
mouse embryo
multi-potent progenitors
Issue Date28-Mar-2023
PublisherCell Press
Citation
Cell Reports, 2023, v. 42, n. 3 How to Cite?
Abstract

It is widely believed that hematopoiesis after birth is established by hematopoietic stem cells (HSCs) in the bone marrow and that HSC-independent hematopoiesis is limited only to primitive erythro-myeloid cells and tissue-resident innate immune cells arising in the embryo. Here, surprisingly, we find that significant percentages of lymphocytes are not derived from HSCs, even in 1-year-old mice. Instead, multiple waves of hematopoiesis occur from embryonic day 7.5 (E7.5) to E11.5 endothelial cells, which simultaneously produce HSCs and lymphoid progenitors that constitute many layers of adaptive T and B lymphocytes in adult mice. Additionally, HSC lineage tracing reveals that the contribution of fetal liver HSCs to peritoneal B-1a cells is minimal and that the majority of B-1a cells are HSC independent. Our discovery of extensive HSC-independent lymphocytes in adult mice attests to the complex blood developmental dynamics spanning the embryo-to-adult transition and challenges the paradigm of HSCs exclusively underpinning the postnatal immune system.


Persistent Identifierhttp://hdl.handle.net/10722/330965
ISSN
2023 Impact Factor: 7.5
2023 SCImago Journal Rankings: 4.279
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKobayashi, M-
dc.contributor.authorWei, HC-
dc.contributor.authorYamanashi, T-
dc.contributor.authorPortilho, NA-
dc.contributor.authorCornelius, S-
dc.contributor.authorValiente, N-
dc.contributor.authorNishida, C-
dc.contributor.authorCheng, HZ-
dc.contributor.authorLatorre, A-
dc.contributor.authorZheng, WJ-
dc.contributor.authorKang, JS-
dc.contributor.authorSeita, J-
dc.contributor.authorShih, DJ-
dc.contributor.authorQian, J-
dc.contributor.authorYoshimoto, M-
dc.date.accessioned2023-09-21T06:51:36Z-
dc.date.available2023-09-21T06:51:36Z-
dc.date.issued2023-03-28-
dc.identifier.citationCell Reports, 2023, v. 42, n. 3-
dc.identifier.issn2211-1247-
dc.identifier.urihttp://hdl.handle.net/10722/330965-
dc.description.abstract<p>It is widely believed that hematopoiesis after birth is established by hematopoietic stem cells (HSCs) in the bone marrow and that HSC-independent hematopoiesis is limited only to primitive erythro-myeloid cells and tissue-resident innate immune cells arising in the embryo. Here, surprisingly, we find that significant percentages of lymphocytes are not derived from HSCs, even in 1-year-old mice. Instead, multiple waves of hematopoiesis occur from embryonic day 7.5 (E7.5) to E11.5 endothelial cells, which simultaneously produce HSCs and lymphoid progenitors that constitute many layers of adaptive T and B lymphocytes in adult mice. Additionally, HSC lineage tracing reveals that the contribution of fetal liver HSCs to peritoneal B-1a cells is minimal and that the majority of B-1a cells are HSC independent. Our discovery of extensive HSC-independent lymphocytes in adult mice attests to the complex blood developmental dynamics spanning the embryo-to-adult transition and challenges the paradigm of HSCs exclusively underpinning the postnatal immune system.</p>-
dc.languageeng-
dc.publisherCell Press-
dc.relation.ispartofCell Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectadaptive immune lymphocytes-
dc.subjectAGM region-
dc.subjectB-1a cells-
dc.subjectCP: Developmental biology-
dc.subjecthemogenic endothelial cells-
dc.subjectHSC precursors-
dc.subjectHSC-independent hematopoiesis-
dc.subjectlineage tracing mouse models-
dc.subjectmouse embryo-
dc.subjectmulti-potent progenitors-
dc.titleHSC-independent definitive hematopoiesis persists into adult life-
dc.typeArticle-
dc.identifier.doi10.1016/j.celrep.2023.112239-
dc.identifier.scopuseid_2-s2.0-85149886643-
dc.identifier.volume42-
dc.identifier.issue3-
dc.identifier.isiWOS:000972561800001-
dc.identifier.issnl2211-1247-

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