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Article: Intranasal vasopressin like oxytocin increases social attention by influencing top-down control, but additionally enhances bottom-up control

TitleIntranasal vasopressin like oxytocin increases social attention by influencing top-down control, but additionally enhances bottom-up control
Authors
KeywordsAnti-saccade task
Arginine vasopressin
Attention control
Emotion
Oxytocin
Issue Date2021
Citation
Psychoneuroendocrinology, 2021, v. 133, article no. 105412 How to Cite?
AbstractThe respective roles of the neuropeptides arginine vasopressin (AVP) and oxytocin (OXT) in modulating social cognition and for therapeutic intervention in autism spectrum disorder have not been fully established. In particular, while numerous studies have demonstrated effects of oxytocin in promoting social attention the role of AVP has not been examined. The present study employed a randomized, double-blind, placebo (PLC)-controlled between-subject design to explore the social- and emotion-specific effects of AVP on both bottom-up and top-down attention processing with a validated emotional anti-saccade eye-tracking paradigm in 80 healthy male subjects (PLC = 40, AVP = 40). Our findings showed that AVP increased the error rate for social (angry, fearful, happy, neutral and sad faces) but not non-social (oval shapes) stimuli during the anti-saccade condition and reduced error rates in the pro-saccade condition. Comparison of these findings with a previous study (sample size: PLC = 33, OXT = 33) using intranasal oxytocin revealed similar effects of the two peptides on anti-saccade errors, although with some difference in effects of specific face emotions, but a significantly greater effect of AVP on pro-saccades. Both peptides also produced a post-task anxiolytic effect by reducing state anxiety. Together these findings suggested that both AVP and OXT decrease goal-directed top-down attention control to social salient stimuli but that AVP more potently increased bottom-up social attentional processing.
Persistent Identifierhttp://hdl.handle.net/10722/330728
ISSN
2023 Impact Factor: 3.4
2023 SCImago Journal Rankings: 1.373
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhuang, Qian-
dc.contributor.authorZheng, Xiaoxiao-
dc.contributor.authorBecker, Benjamin-
dc.contributor.authorLei, Wei-
dc.contributor.authorXu, Xiaolei-
dc.contributor.authorKendrick, Keith M.-
dc.date.accessioned2023-09-05T12:13:38Z-
dc.date.available2023-09-05T12:13:38Z-
dc.date.issued2021-
dc.identifier.citationPsychoneuroendocrinology, 2021, v. 133, article no. 105412-
dc.identifier.issn0306-4530-
dc.identifier.urihttp://hdl.handle.net/10722/330728-
dc.description.abstractThe respective roles of the neuropeptides arginine vasopressin (AVP) and oxytocin (OXT) in modulating social cognition and for therapeutic intervention in autism spectrum disorder have not been fully established. In particular, while numerous studies have demonstrated effects of oxytocin in promoting social attention the role of AVP has not been examined. The present study employed a randomized, double-blind, placebo (PLC)-controlled between-subject design to explore the social- and emotion-specific effects of AVP on both bottom-up and top-down attention processing with a validated emotional anti-saccade eye-tracking paradigm in 80 healthy male subjects (PLC = 40, AVP = 40). Our findings showed that AVP increased the error rate for social (angry, fearful, happy, neutral and sad faces) but not non-social (oval shapes) stimuli during the anti-saccade condition and reduced error rates in the pro-saccade condition. Comparison of these findings with a previous study (sample size: PLC = 33, OXT = 33) using intranasal oxytocin revealed similar effects of the two peptides on anti-saccade errors, although with some difference in effects of specific face emotions, but a significantly greater effect of AVP on pro-saccades. Both peptides also produced a post-task anxiolytic effect by reducing state anxiety. Together these findings suggested that both AVP and OXT decrease goal-directed top-down attention control to social salient stimuli but that AVP more potently increased bottom-up social attentional processing.-
dc.languageeng-
dc.relation.ispartofPsychoneuroendocrinology-
dc.subjectAnti-saccade task-
dc.subjectArginine vasopressin-
dc.subjectAttention control-
dc.subjectEmotion-
dc.subjectOxytocin-
dc.titleIntranasal vasopressin like oxytocin increases social attention by influencing top-down control, but additionally enhances bottom-up control-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.psyneuen.2021.105412-
dc.identifier.pmid34537624-
dc.identifier.scopuseid_2-s2.0-85114999736-
dc.identifier.volume133-
dc.identifier.spagearticle no. 105412-
dc.identifier.epagearticle no. 105412-
dc.identifier.eissn1873-3360-
dc.identifier.isiWOS:000697702200007-

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