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Article: Temporal Variability in Electrocardiographic Indices in Subjects With Brugada Patterns

TitleTemporal Variability in Electrocardiographic Indices in Subjects With Brugada Patterns
Authors
KeywordsBrugada
ECG
repolarization
temporal
variability
Issue Date2020
Citation
Frontiers in Physiology, 2020, v. 11, article no. 953 How to Cite?
AbstractIntroduction: Patients with Brugada electrocardiographic (ECG) patterns have differing levels of arrhythmic risk. We hypothesized that temporal variations in certain ECG markers may provide additional value for risk stratification. The present study evaluated the relationship between temporal variability of ECG markers and arrhythmic outcomes in patients with a Brugada pattern ECG. Comparisons were made between low-risk asymptomatic subjects versus high-risk symptomatic patients with a history of syncope, ventricular tachycardia (VT) or ventricular fibrillation (VF). Methods: A total of 81 patients presenting with Brugada patterns were recruited. Serial ECGs and electronic health records from January 2004 to April 2019 were analyzed. Temporal variability of QRS interval, J point-Tpeak interval (JTp), Tpeak-Tend interval (Tp-e), and ST elevation (STe) in precordial leads V1-3, in addition to RR-interval from lead II, was assessed using standard deviation and difference between maximum and minimum values over the serial ECGs. Results: Patients presenting with type 1 Brugada ECG pattern initially had significantly higher variability in JTp from lead V2 (SD: 33.5 ± 13.8 vs. 25.2 ± 11.5 ms, P = 0.009; max-min: 98.6 ± 46.2 vs. 78.3 ± 47.6 ms, P = 0.047) and ST elevation in lead V1 (0.117 ± 0.122 vs. 0.053 ± 0.030 mV; P = 0.004). Significantly higher variability in Tp-e interval measured from lead V3 was observed in the VT/VF group compared to the syncope and asymptomatic groups (SD: 20.5 ± 8.5 vs. 16.6 ± 7.3 and 14.7 ± 9.8 ms; P = 0.044; max-min: 70.2 ± 28.9 vs. 56.3 ± 29.0 and 43.5 ± 28.5 ms; P = 0.011). Conclusion: Temporal variability in ECG indices may provide additional value for risk stratification in patients with Brugada pattern.
Persistent Identifierhttp://hdl.handle.net/10722/330661
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, Sharen-
dc.contributor.authorZhou, Jiandong-
dc.contributor.authorLiu, Tong-
dc.contributor.authorLetsas, Konstantinos P.-
dc.contributor.authorHothi, Sandeep S.-
dc.contributor.authorVassiliou, Vassilios S.-
dc.contributor.authorLi, Guoliang-
dc.contributor.authorBaranchuk, Adrian-
dc.contributor.authorSy, Raymond W.-
dc.contributor.authorChang, Dong-
dc.contributor.authorZhang, Qingpeng-
dc.contributor.authorTse, Gary-
dc.date.accessioned2023-09-05T12:12:53Z-
dc.date.available2023-09-05T12:12:53Z-
dc.date.issued2020-
dc.identifier.citationFrontiers in Physiology, 2020, v. 11, article no. 953-
dc.identifier.urihttp://hdl.handle.net/10722/330661-
dc.description.abstractIntroduction: Patients with Brugada electrocardiographic (ECG) patterns have differing levels of arrhythmic risk. We hypothesized that temporal variations in certain ECG markers may provide additional value for risk stratification. The present study evaluated the relationship between temporal variability of ECG markers and arrhythmic outcomes in patients with a Brugada pattern ECG. Comparisons were made between low-risk asymptomatic subjects versus high-risk symptomatic patients with a history of syncope, ventricular tachycardia (VT) or ventricular fibrillation (VF). Methods: A total of 81 patients presenting with Brugada patterns were recruited. Serial ECGs and electronic health records from January 2004 to April 2019 were analyzed. Temporal variability of QRS interval, J point-Tpeak interval (JTp), Tpeak-Tend interval (Tp-e), and ST elevation (STe) in precordial leads V1-3, in addition to RR-interval from lead II, was assessed using standard deviation and difference between maximum and minimum values over the serial ECGs. Results: Patients presenting with type 1 Brugada ECG pattern initially had significantly higher variability in JTp from lead V2 (SD: 33.5 ± 13.8 vs. 25.2 ± 11.5 ms, P = 0.009; max-min: 98.6 ± 46.2 vs. 78.3 ± 47.6 ms, P = 0.047) and ST elevation in lead V1 (0.117 ± 0.122 vs. 0.053 ± 0.030 mV; P = 0.004). Significantly higher variability in Tp-e interval measured from lead V3 was observed in the VT/VF group compared to the syncope and asymptomatic groups (SD: 20.5 ± 8.5 vs. 16.6 ± 7.3 and 14.7 ± 9.8 ms; P = 0.044; max-min: 70.2 ± 28.9 vs. 56.3 ± 29.0 and 43.5 ± 28.5 ms; P = 0.011). Conclusion: Temporal variability in ECG indices may provide additional value for risk stratification in patients with Brugada pattern.-
dc.languageeng-
dc.relation.ispartofFrontiers in Physiology-
dc.subjectBrugada-
dc.subjectECG-
dc.subjectrepolarization-
dc.subjecttemporal-
dc.subjectvariability-
dc.titleTemporal Variability in Electrocardiographic Indices in Subjects With Brugada Patterns-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3389/fphys.2020.00953-
dc.identifier.scopuseid_2-s2.0-85091105287-
dc.identifier.volume11-
dc.identifier.spagearticle no. 953-
dc.identifier.epagearticle no. 953-
dc.identifier.eissn1664-042X-
dc.identifier.isiWOS:000570529000001-

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