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Article: Oxytocin reduces top-down control of attention by increasing bottom-up attention allocation to social but not non-social stimuli – A randomized controlled trial

TitleOxytocin reduces top-down control of attention by increasing bottom-up attention allocation to social but not non-social stimuli – A randomized controlled trial
Authors
KeywordsAttention
Cognitive control
Emotion
Eye gaze
Oxytocin
Social salience
Issue Date2019
Citation
Psychoneuroendocrinology, 2019, v. 108, p. 62-69 How to Cite?
AbstractThe neuropeptide oxytocin (OXT) may facilitate attention to social stimuli by influencing early stage bottom-up processing although findings in relation to different emotional expressions are inconsistent and its influence on top-down cognitive processing mechanisms unclear. In the current double-blind placebo (PLC) controlled between-subject design study we therefore recruited 71 male subjects (OXT = 34, PLC = 37) to investigate the effects of intranasal OXT (24IU) on both bottom-up attention allocation and top-down attention inhibition using a prosaccade and antisaccade paradigm incorporating social (neutral, happy, fearful, sad, angry faces) and non-social (oval shape) visual stimuli with concurrent eye movement acquisition. Results revealed a marginal significant interaction effect between treatment, condition and task (p = 0.054), with Bonferroni-corrected post-hoc tests indicating that OXT specifically increased antisaccade errors for social stimuli (ps < 0.04, effect sizes 0.46-0.88), but not non-social stimuli. Antisaccades are under volitional control and therefore this may indicate that OXT treatment reduced top-down inhibition. However, the overall findings are consistent with OXT acting to reduce top-down control of attention as a result of increasing bottom-up early attentional processing of social, but not non-social, stimuli in situations where the two systems are in potential conflict. Marked deficits in bottom-up attention allocation to social stimuli have been reported in autism spectrum disorder, within this context OXT may have the potential to increase early attention allocation towards social cues.
Persistent Identifierhttp://hdl.handle.net/10722/330608
ISSN
2023 Impact Factor: 3.4
2023 SCImago Journal Rankings: 1.373
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXu, Xiaolei-
dc.contributor.authorLi, Jialin-
dc.contributor.authorChen, Zhuo-
dc.contributor.authorKendrick, Keith M.-
dc.contributor.authorBecker, Benjamin-
dc.date.accessioned2023-09-05T12:12:15Z-
dc.date.available2023-09-05T12:12:15Z-
dc.date.issued2019-
dc.identifier.citationPsychoneuroendocrinology, 2019, v. 108, p. 62-69-
dc.identifier.issn0306-4530-
dc.identifier.urihttp://hdl.handle.net/10722/330608-
dc.description.abstractThe neuropeptide oxytocin (OXT) may facilitate attention to social stimuli by influencing early stage bottom-up processing although findings in relation to different emotional expressions are inconsistent and its influence on top-down cognitive processing mechanisms unclear. In the current double-blind placebo (PLC) controlled between-subject design study we therefore recruited 71 male subjects (OXT = 34, PLC = 37) to investigate the effects of intranasal OXT (24IU) on both bottom-up attention allocation and top-down attention inhibition using a prosaccade and antisaccade paradigm incorporating social (neutral, happy, fearful, sad, angry faces) and non-social (oval shape) visual stimuli with concurrent eye movement acquisition. Results revealed a marginal significant interaction effect between treatment, condition and task (p = 0.054), with Bonferroni-corrected post-hoc tests indicating that OXT specifically increased antisaccade errors for social stimuli (ps < 0.04, effect sizes 0.46-0.88), but not non-social stimuli. Antisaccades are under volitional control and therefore this may indicate that OXT treatment reduced top-down inhibition. However, the overall findings are consistent with OXT acting to reduce top-down control of attention as a result of increasing bottom-up early attentional processing of social, but not non-social, stimuli in situations where the two systems are in potential conflict. Marked deficits in bottom-up attention allocation to social stimuli have been reported in autism spectrum disorder, within this context OXT may have the potential to increase early attention allocation towards social cues.-
dc.languageeng-
dc.relation.ispartofPsychoneuroendocrinology-
dc.subjectAttention-
dc.subjectCognitive control-
dc.subjectEmotion-
dc.subjectEye gaze-
dc.subjectOxytocin-
dc.subjectSocial salience-
dc.titleOxytocin reduces top-down control of attention by increasing bottom-up attention allocation to social but not non-social stimuli – A randomized controlled trial-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.psyneuen.2019.06.004-
dc.identifier.pmid31229634-
dc.identifier.scopuseid_2-s2.0-85067506295-
dc.identifier.volume108-
dc.identifier.spage62-
dc.identifier.epage69-
dc.identifier.eissn1873-3360-
dc.identifier.isiWOS:000484870800008-

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