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Article: Real-Time Functional Connectivity-Informed Neurofeedback of Amygdala-Frontal Pathways Reduces Anxiety

TitleReal-Time Functional Connectivity-Informed Neurofeedback of Amygdala-Frontal Pathways Reduces Anxiety
Authors
KeywordsAmygdala
Anxiety
Anxiolytic treatment
Connectivity
Emotion regulation
Functional magnetic resonance imaging
Network
Prefrontal cortex
Real-time neurofeedback
Treatment
Issue Date2019
Citation
Psychotherapy and Psychosomatics, 2019, v. 88, n. 1, p. 5-15 How to Cite?
AbstractBackground: Deficient emotion regulation and exaggerated anxiety represent a major transdiagnostic psychopathological marker. On the neural level these deficits have been closely linked to impaired, yet treatment-sensitive, prefrontal regulatory control over the amygdala. Gaining direct control over these pathways could therefore provide an innovative and promising intervention to regulate exaggerated anxiety. To this end the current proof-of-concept study evaluated the feasibility, functional relevance and maintenance of a novel connectivity-informed real-time fMRI neurofeedback training. Methods: In a randomized crossover sham-controlled design, 26 healthy subjects with high anxiety underwent real-time fMRI-guided neurofeedback training to enhance connectivity between the ventrolateral prefrontal cortex (vlPFC) and the amygdala (target pathway) during threat exposure. Maintenance of regulatory control was assessed after 3 days and in the absence of feedback. Training-induced changes in functional connectivity of the target pathway and anxiety ratings served as primary outcomes. Results: Training of the target, yet not the sham control, pathway significantly increased amygdala-vlPFC connectivity and decreased levels of anxiety. Stronger connectivity increases were significantly associated with higher anxiety reduction on the group level. At the follow-up, volitional control over the target pathway was maintained in the absence of feedback. Conclusions: The present results demonstrate for the first time that successful self-regulation of amygdala-prefrontal top-down regulatory circuits may represent a novel intervention to control anxiety. As such, the present findings underscore both the critical contribution of amygdala-prefrontal circuits to emotion regulation and the therapeutic potential of connectivity-informed real-time neurofeedback.
Persistent Identifierhttp://hdl.handle.net/10722/330596
ISSN
2023 Impact Factor: 16.3
2023 SCImago Journal Rankings: 5.104
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhao, Zhiying-
dc.contributor.authorYao, Shuxia-
dc.contributor.authorLi, Keshuang-
dc.contributor.authorSindermann, Cornelia-
dc.contributor.authorZhou, Feng-
dc.contributor.authorZhao, Weihua-
dc.contributor.authorLi, Jianfu-
dc.contributor.authorLührs, Michael-
dc.contributor.authorGoebel, Rainer-
dc.contributor.authorKendrick, Keith M.-
dc.contributor.authorBecker, Benjamin-
dc.date.accessioned2023-09-05T12:12:07Z-
dc.date.available2023-09-05T12:12:07Z-
dc.date.issued2019-
dc.identifier.citationPsychotherapy and Psychosomatics, 2019, v. 88, n. 1, p. 5-15-
dc.identifier.issn0033-3190-
dc.identifier.urihttp://hdl.handle.net/10722/330596-
dc.description.abstractBackground: Deficient emotion regulation and exaggerated anxiety represent a major transdiagnostic psychopathological marker. On the neural level these deficits have been closely linked to impaired, yet treatment-sensitive, prefrontal regulatory control over the amygdala. Gaining direct control over these pathways could therefore provide an innovative and promising intervention to regulate exaggerated anxiety. To this end the current proof-of-concept study evaluated the feasibility, functional relevance and maintenance of a novel connectivity-informed real-time fMRI neurofeedback training. Methods: In a randomized crossover sham-controlled design, 26 healthy subjects with high anxiety underwent real-time fMRI-guided neurofeedback training to enhance connectivity between the ventrolateral prefrontal cortex (vlPFC) and the amygdala (target pathway) during threat exposure. Maintenance of regulatory control was assessed after 3 days and in the absence of feedback. Training-induced changes in functional connectivity of the target pathway and anxiety ratings served as primary outcomes. Results: Training of the target, yet not the sham control, pathway significantly increased amygdala-vlPFC connectivity and decreased levels of anxiety. Stronger connectivity increases were significantly associated with higher anxiety reduction on the group level. At the follow-up, volitional control over the target pathway was maintained in the absence of feedback. Conclusions: The present results demonstrate for the first time that successful self-regulation of amygdala-prefrontal top-down regulatory circuits may represent a novel intervention to control anxiety. As such, the present findings underscore both the critical contribution of amygdala-prefrontal circuits to emotion regulation and the therapeutic potential of connectivity-informed real-time neurofeedback.-
dc.languageeng-
dc.relation.ispartofPsychotherapy and Psychosomatics-
dc.subjectAmygdala-
dc.subjectAnxiety-
dc.subjectAnxiolytic treatment-
dc.subjectConnectivity-
dc.subjectEmotion regulation-
dc.subjectFunctional magnetic resonance imaging-
dc.subjectNetwork-
dc.subjectPrefrontal cortex-
dc.subjectReal-time neurofeedback-
dc.subjectTreatment-
dc.titleReal-Time Functional Connectivity-Informed Neurofeedback of Amygdala-Frontal Pathways Reduces Anxiety-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000496057-
dc.identifier.pmid30699438-
dc.identifier.scopuseid_2-s2.0-85060920234-
dc.identifier.volume88-
dc.identifier.issue1-
dc.identifier.spage5-
dc.identifier.epage15-
dc.identifier.eissn1423-0348-
dc.identifier.isiWOS:000462044000002-

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