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Article: Emotion regulation deficits in regular marijuana users

TitleEmotion regulation deficits in regular marijuana users
Authors
Keywordsamygdala
marijuana use
negative affect
prefrontal cortex
reappraisal
Issue Date2017
Citation
Human Brain Mapping, 2017, v. 38, n. 8, p. 4270-4279 How to Cite?
AbstractEffective regulation of negative affective states has been associated with mental health. Impaired regulation of negative affect represents a risk factor for dysfunctional coping mechanisms such as drug use and thus could contribute to the initiation and development of problematic substance use. This study investigated behavioral and neural indices of emotion regulation in regular marijuana users (n = 23) and demographically matched nonusing controls (n = 20) by means of an fMRI cognitive emotion regulation (reappraisal) paradigm. Relative to nonusing controls, marijuana users demonstrated increased neural activity in a bilateral frontal network comprising precentral, middle cingulate, and supplementary motor regions during reappraisal of negative affect (P < 0.05, FWE) and impaired emotion regulation success on the behavioral level (P < 0.05). Amygdala-focused analyses further revealed impaired amygdala downregulation in the context of decreased amygdala–dorsolateral prefrontal cortex functional connectivity (P < 0.05, FWE) during reappraisal in marijuana users relative to controls. Together, the present findings could reflect an unsuccessful attempt of compensatory recruitment of additional neural resources in the context of disrupted amygdala–prefrontal interaction during volitional emotion regulation in marijuana users. As such, impaired volitional regulation of negative affect might represent a consequence of, or risk factor for, regular marijuana use. Hum Brain Mapp 38:4270–4279, 2017. © 2017 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/330549
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 1.626
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZimmermann, Kaeli-
dc.contributor.authorWalz, Christina-
dc.contributor.authorDerckx, Raissa T.-
dc.contributor.authorKendrick, Keith M.-
dc.contributor.authorWeber, Bernd-
dc.contributor.authorDore, Bruce-
dc.contributor.authorOchsner, Kevin N.-
dc.contributor.authorHurlemann, René-
dc.contributor.authorBecker, Benjamin-
dc.date.accessioned2023-09-05T12:11:42Z-
dc.date.available2023-09-05T12:11:42Z-
dc.date.issued2017-
dc.identifier.citationHuman Brain Mapping, 2017, v. 38, n. 8, p. 4270-4279-
dc.identifier.issn1065-9471-
dc.identifier.urihttp://hdl.handle.net/10722/330549-
dc.description.abstractEffective regulation of negative affective states has been associated with mental health. Impaired regulation of negative affect represents a risk factor for dysfunctional coping mechanisms such as drug use and thus could contribute to the initiation and development of problematic substance use. This study investigated behavioral and neural indices of emotion regulation in regular marijuana users (n = 23) and demographically matched nonusing controls (n = 20) by means of an fMRI cognitive emotion regulation (reappraisal) paradigm. Relative to nonusing controls, marijuana users demonstrated increased neural activity in a bilateral frontal network comprising precentral, middle cingulate, and supplementary motor regions during reappraisal of negative affect (P < 0.05, FWE) and impaired emotion regulation success on the behavioral level (P < 0.05). Amygdala-focused analyses further revealed impaired amygdala downregulation in the context of decreased amygdala–dorsolateral prefrontal cortex functional connectivity (P < 0.05, FWE) during reappraisal in marijuana users relative to controls. Together, the present findings could reflect an unsuccessful attempt of compensatory recruitment of additional neural resources in the context of disrupted amygdala–prefrontal interaction during volitional emotion regulation in marijuana users. As such, impaired volitional regulation of negative affect might represent a consequence of, or risk factor for, regular marijuana use. Hum Brain Mapp 38:4270–4279, 2017. © 2017 Wiley Periodicals, Inc.-
dc.languageeng-
dc.relation.ispartofHuman Brain Mapping-
dc.subjectamygdala-
dc.subjectmarijuana use-
dc.subjectnegative affect-
dc.subjectprefrontal cortex-
dc.subjectreappraisal-
dc.titleEmotion regulation deficits in regular marijuana users-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hbm.23671-
dc.identifier.pmid28560818-
dc.identifier.scopuseid_2-s2.0-85019714640-
dc.identifier.volume38-
dc.identifier.issue8-
dc.identifier.spage4270-
dc.identifier.epage4279-
dc.identifier.eissn1097-0193-
dc.identifier.isiWOS:000404963900035-

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