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Article: Oxytocin, the peptide that bonds the sexes also divides them

TitleOxytocin, the peptide that bonds the sexes also divides them
Authors
KeywordsAmygdala
Functional imaging
Oxytocin
Sex differences
Social cognition
Issue Date2016
Citation
Proceedings of the National Academy of Sciences of the United States of America, 2016, v. 113, n. 27, p. 7650-7654 How to Cite?
AbstractFacilitation of social attraction and bonding by the evolutionarily conserved neuropeptide oxytocin is well-established in female mammals. However, accumulating behavioral evidence suggests that oxytocin may have evolved sex-specific functional roles in the domain of human social cognition. A critical question is how oxytocin differentially modulates neural processing of social information in men and women, leading to divergent behavioral responses. Here we show that intranasal oxytocin treatment produces sex- and valence-dependent increases in amygdala activation when women view individuals identified as praising others but in men those who criticize them. Women subsequently show increased liking for the faces of these individuals, whereas in men it is reduced. Thus, oxytocin may act differentially via the amygdala to enhance the salience of positive social attributes in women but negative ones in men. We hypothesize that oxytocin may have evolved different but complementary roles to help ensure successful reproduction by encouraging mothers to promote a prosocial rearing environment for offspring and fathers to protect against antisocial influences.
Persistent Identifierhttp://hdl.handle.net/10722/330529
ISSN
2023 Impact Factor: 9.4
2023 SCImago Journal Rankings: 3.737
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGao, Shan-
dc.contributor.authorBecker, Benjamin-
dc.contributor.authorLuo, Lizhu-
dc.contributor.authorGeng, Yayuan-
dc.contributor.authorZhao, Weihua-
dc.contributor.authorYin, Yu-
dc.contributor.authorHu, Jiehui-
dc.contributor.authorGao, Zhao-
dc.contributor.authorGong, Qiyong-
dc.contributor.authorHurlemann, Rene-
dc.contributor.authorYao, Dezhong-
dc.contributor.authorKendrick, Keith M.-
dc.date.accessioned2023-09-05T12:11:30Z-
dc.date.available2023-09-05T12:11:30Z-
dc.date.issued2016-
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2016, v. 113, n. 27, p. 7650-7654-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10722/330529-
dc.description.abstractFacilitation of social attraction and bonding by the evolutionarily conserved neuropeptide oxytocin is well-established in female mammals. However, accumulating behavioral evidence suggests that oxytocin may have evolved sex-specific functional roles in the domain of human social cognition. A critical question is how oxytocin differentially modulates neural processing of social information in men and women, leading to divergent behavioral responses. Here we show that intranasal oxytocin treatment produces sex- and valence-dependent increases in amygdala activation when women view individuals identified as praising others but in men those who criticize them. Women subsequently show increased liking for the faces of these individuals, whereas in men it is reduced. Thus, oxytocin may act differentially via the amygdala to enhance the salience of positive social attributes in women but negative ones in men. We hypothesize that oxytocin may have evolved different but complementary roles to help ensure successful reproduction by encouraging mothers to promote a prosocial rearing environment for offspring and fathers to protect against antisocial influences.-
dc.languageeng-
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America-
dc.subjectAmygdala-
dc.subjectFunctional imaging-
dc.subjectOxytocin-
dc.subjectSex differences-
dc.subjectSocial cognition-
dc.titleOxytocin, the peptide that bonds the sexes also divides them-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1073/pnas.1602620113-
dc.identifier.pmid27325780-
dc.identifier.scopuseid_2-s2.0-84977525471-
dc.identifier.volume113-
dc.identifier.issue27-
dc.identifier.spage7650-
dc.identifier.epage7654-
dc.identifier.eissn1091-6490-
dc.identifier.isiWOS:000379021700089-

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