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Article: Dysregulated anterior insula reactivity as robust functional biomarker for chronic pain—Meta-analytic evidence from neuroimaging studies

TitleDysregulated anterior insula reactivity as robust functional biomarker for chronic pain—Meta-analytic evidence from neuroimaging studies
Authors
Issue Date2022
Citation
Human Brain Mapping, 2022, v. 43, n. 3, p. 998-1010 How to Cite?
AbstractNeurobiological pain models propose that chronic pain is accompanied by neurofunctional changes that mediate pain processing dysfunctions. In contrast, meta-analyses of neuroimaging studies in chronic pain conditions have not revealed convergent evidence for robust alterations during experimental pain induction. Against this background, the present neuroimaging meta-analysis combined three different meta-analytic approaches with stringent study selection criteria for case–control functional magnetic resonance imaging experiments during acute pain processing with a focus on chronic pain disorders. Convergent neurofunctional dysregulations in chronic pain patients were observed in the left anterior insula cortex. Seed-based resting-state functional connectivity based on a large publicly available dataset combined with a meta-analytic task-based approach identified the anterior insular region as a key node of an extended bilateral insula-fronto-cingular network, resembling the salience network. Moreover, the meta-analytic decoding showed that this region presents a high probability to be specifically activated during pain-related processes, although we cannot exclude an involvement in autonomic processes. Together, the present findings indicate that dysregulated left anterior insular activity represents a robust neurofunctional maladaptation and potential treatment target in chronic pain disorders.
Persistent Identifierhttp://hdl.handle.net/10722/330456
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 1.626
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFerraro, Stefania-
dc.contributor.authorKlugah-Brown, Benjamin-
dc.contributor.authorTench, Christopher R.-
dc.contributor.authorYao, Shuxia-
dc.contributor.authorNigri, Anna-
dc.contributor.authorDemichelis, Greta-
dc.contributor.authorPinardi, Chiara-
dc.contributor.authorBruzzone, Maria Grazia-
dc.contributor.authorBecker, Benjamin-
dc.date.accessioned2023-09-05T12:10:49Z-
dc.date.available2023-09-05T12:10:49Z-
dc.date.issued2022-
dc.identifier.citationHuman Brain Mapping, 2022, v. 43, n. 3, p. 998-1010-
dc.identifier.issn1065-9471-
dc.identifier.urihttp://hdl.handle.net/10722/330456-
dc.description.abstractNeurobiological pain models propose that chronic pain is accompanied by neurofunctional changes that mediate pain processing dysfunctions. In contrast, meta-analyses of neuroimaging studies in chronic pain conditions have not revealed convergent evidence for robust alterations during experimental pain induction. Against this background, the present neuroimaging meta-analysis combined three different meta-analytic approaches with stringent study selection criteria for case–control functional magnetic resonance imaging experiments during acute pain processing with a focus on chronic pain disorders. Convergent neurofunctional dysregulations in chronic pain patients were observed in the left anterior insula cortex. Seed-based resting-state functional connectivity based on a large publicly available dataset combined with a meta-analytic task-based approach identified the anterior insular region as a key node of an extended bilateral insula-fronto-cingular network, resembling the salience network. Moreover, the meta-analytic decoding showed that this region presents a high probability to be specifically activated during pain-related processes, although we cannot exclude an involvement in autonomic processes. Together, the present findings indicate that dysregulated left anterior insular activity represents a robust neurofunctional maladaptation and potential treatment target in chronic pain disorders.-
dc.languageeng-
dc.relation.ispartofHuman Brain Mapping-
dc.titleDysregulated anterior insula reactivity as robust functional biomarker for chronic pain—Meta-analytic evidence from neuroimaging studies-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hbm.25702-
dc.identifier.pmid34734458-
dc.identifier.scopuseid_2-s2.0-85118494173-
dc.identifier.volume43-
dc.identifier.issue3-
dc.identifier.spage998-
dc.identifier.epage1010-
dc.identifier.eissn1097-0193-
dc.identifier.isiWOS:000714253300001-

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