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Article: A dimensional approach to determine common and specific neurofunctional markers for depression and social anxiety during emotional face processing

TitleA dimensional approach to determine common and specific neurofunctional markers for depression and social anxiety during emotional face processing
Authors
Keywordsbiomarker
depression
face emotion
putamen
social anxiety
trait
Issue Date2018
Citation
Human Brain Mapping, 2018, v. 39, n. 2, p. 758-771 How to Cite?
AbstractMajor depression disorder (MDD) and anxiety disorder are both prevalent and debilitating. High rates of comorbidity between MDD and social anxiety disorder (SAD) suggest common pathological pathways, including aberrant neural processing of interpersonal signals. In patient populations, the determination of common and distinct neurofunctional markers of MDD and SAD is often hampered by confounding factors, such as generally elevated anxiety levels and disorder-specific brain structural alterations. This study employed a dimensional disorder approach to map neurofunctional markers associated with levels of depression and social anxiety symptoms in a cohort of 91 healthy subjects using an emotional face processing paradigm. Examining linear associations between levels of depression and social anxiety, while controlling for trait anxiety revealed that both were associated with exaggerated dorsal striatal reactivity to fearful and sad expression faces respectively. Exploratory analysis revealed that depression scores were positively correlated with dorsal striatal functional connectivity during processing of fearful faces, whereas those of social anxiety showed a negative association during processing of sad faces. No linear relationships between levels of depression and social anxiety were observed during a facial-identity matching task or with brain structure. Together, the present findings indicate that dorsal striatal neurofunctional alterations might underlie aberrant interpersonal processing associated with both increased levels of depression and social anxiety.
Persistent Identifierhttp://hdl.handle.net/10722/330387
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 1.626
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLuo, Lizhu-
dc.contributor.authorBecker, Benjamin-
dc.contributor.authorZheng, Xiaoxiao-
dc.contributor.authorZhao, Zhiying-
dc.contributor.authorXu, Xiaolei-
dc.contributor.authorZhou, Feng-
dc.contributor.authorWang, Jiaojian-
dc.contributor.authorKou, Juan-
dc.contributor.authorDai, Jing-
dc.contributor.authorKendrick, Keith M.-
dc.date.accessioned2023-09-05T12:10:08Z-
dc.date.available2023-09-05T12:10:08Z-
dc.date.issued2018-
dc.identifier.citationHuman Brain Mapping, 2018, v. 39, n. 2, p. 758-771-
dc.identifier.issn1065-9471-
dc.identifier.urihttp://hdl.handle.net/10722/330387-
dc.description.abstractMajor depression disorder (MDD) and anxiety disorder are both prevalent and debilitating. High rates of comorbidity between MDD and social anxiety disorder (SAD) suggest common pathological pathways, including aberrant neural processing of interpersonal signals. In patient populations, the determination of common and distinct neurofunctional markers of MDD and SAD is often hampered by confounding factors, such as generally elevated anxiety levels and disorder-specific brain structural alterations. This study employed a dimensional disorder approach to map neurofunctional markers associated with levels of depression and social anxiety symptoms in a cohort of 91 healthy subjects using an emotional face processing paradigm. Examining linear associations between levels of depression and social anxiety, while controlling for trait anxiety revealed that both were associated with exaggerated dorsal striatal reactivity to fearful and sad expression faces respectively. Exploratory analysis revealed that depression scores were positively correlated with dorsal striatal functional connectivity during processing of fearful faces, whereas those of social anxiety showed a negative association during processing of sad faces. No linear relationships between levels of depression and social anxiety were observed during a facial-identity matching task or with brain structure. Together, the present findings indicate that dorsal striatal neurofunctional alterations might underlie aberrant interpersonal processing associated with both increased levels of depression and social anxiety.-
dc.languageeng-
dc.relation.ispartofHuman Brain Mapping-
dc.subjectbiomarker-
dc.subjectdepression-
dc.subjectface emotion-
dc.subjectputamen-
dc.subjectsocial anxiety-
dc.subjecttrait-
dc.titleA dimensional approach to determine common and specific neurofunctional markers for depression and social anxiety during emotional face processing-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hbm.23880-
dc.identifier.pmid29105895-
dc.identifier.scopuseid_2-s2.0-85032882332-
dc.identifier.volume39-
dc.identifier.issue2-
dc.identifier.spage758-
dc.identifier.epage771-
dc.identifier.eissn1097-0193-
dc.identifier.isiWOS:000419856200012-

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