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Article: Oxytocin selectively facilitates learning with social feedback and increases activity and functional connectivity in emotional memory and reward processing regions

TitleOxytocin selectively facilitates learning with social feedback and increases activity and functional connectivity in emotional memory and reward processing regions
Authors
KeywordsEmotional memory
FMRI
Functional connectivity
Oxytocin
Reinforcement learning
Issue Date2015
Citation
Human Brain Mapping, 2015, v. 36, n. 6, p. 2132-2146 How to Cite?
AbstractIn male Caucasian subjects, learning is facilitated by receipt of social compared with non-social feedback, and the neuropeptide oxytocin (OXT) facilitates this effect. In this study, we have first shown a cultural difference in that male Chinese subjects actually perform significantly worse in the same reinforcement associated learning task with social (emotional faces) compared with non-social feedback. Nevertheless, in two independent double-blind placebo (PLC) controlled between-subject design experiments we found OXT still selectively facilitated learning with social feedback. Similar to Caucasian subjects this OXT effect was strongest with feedback using female rather than male faces. One experiment performed in conjunction with functional magnetic resonance imaging showed that during the response, but not feedback phase of the task, OXT selectively increased activity in the amygdala, hippocampus, parahippocampal gyrus and putamen during the social feedback condition, and functional connectivity between the amygdala and insula and caudate. Therefore, OXT may be increasing the salience and reward value of anticipated social feedback. In the PLC group, response times and state anxiety scores during social feedback were associated with signal changes in these same regions but not in the OXT group. OXT may therefore have also facilitated learning by reducing anxiety in the social feedback condition. Overall our results provide the first evidence for cultural differences in social facilitation of learning per se, but a similar selective enhancement of learning with social feedback under OXT. This effect of OXT may be associated with enhanced responses and functional connectivity in emotional memory and reward processing regions.
Persistent Identifierhttp://hdl.handle.net/10722/330375
ISSN
2022 Impact Factor: 4.8
2020 SCImago Journal Rankings: 2.005
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHu, Jiehui-
dc.contributor.authorQi, Song-
dc.contributor.authorBecker, Benjamin-
dc.contributor.authorLuo, Lizhu-
dc.contributor.authorGao, Shan-
dc.contributor.authorGong, Qiyong-
dc.contributor.authorHurlemann, René-
dc.contributor.authorKendrick, Keith M.-
dc.date.accessioned2023-09-05T12:10:03Z-
dc.date.available2023-09-05T12:10:03Z-
dc.date.issued2015-
dc.identifier.citationHuman Brain Mapping, 2015, v. 36, n. 6, p. 2132-2146-
dc.identifier.issn1065-9471-
dc.identifier.urihttp://hdl.handle.net/10722/330375-
dc.description.abstractIn male Caucasian subjects, learning is facilitated by receipt of social compared with non-social feedback, and the neuropeptide oxytocin (OXT) facilitates this effect. In this study, we have first shown a cultural difference in that male Chinese subjects actually perform significantly worse in the same reinforcement associated learning task with social (emotional faces) compared with non-social feedback. Nevertheless, in two independent double-blind placebo (PLC) controlled between-subject design experiments we found OXT still selectively facilitated learning with social feedback. Similar to Caucasian subjects this OXT effect was strongest with feedback using female rather than male faces. One experiment performed in conjunction with functional magnetic resonance imaging showed that during the response, but not feedback phase of the task, OXT selectively increased activity in the amygdala, hippocampus, parahippocampal gyrus and putamen during the social feedback condition, and functional connectivity between the amygdala and insula and caudate. Therefore, OXT may be increasing the salience and reward value of anticipated social feedback. In the PLC group, response times and state anxiety scores during social feedback were associated with signal changes in these same regions but not in the OXT group. OXT may therefore have also facilitated learning by reducing anxiety in the social feedback condition. Overall our results provide the first evidence for cultural differences in social facilitation of learning per se, but a similar selective enhancement of learning with social feedback under OXT. This effect of OXT may be associated with enhanced responses and functional connectivity in emotional memory and reward processing regions.-
dc.languageeng-
dc.relation.ispartofHuman Brain Mapping-
dc.subjectEmotional memory-
dc.subjectFMRI-
dc.subjectFunctional connectivity-
dc.subjectOxytocin-
dc.subjectReinforcement learning-
dc.titleOxytocin selectively facilitates learning with social feedback and increases activity and functional connectivity in emotional memory and reward processing regions-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hbm.22760-
dc.identifier.pmid25664702-
dc.identifier.scopuseid_2-s2.0-84928755621-
dc.identifier.volume36-
dc.identifier.issue6-
dc.identifier.spage2132-
dc.identifier.epage2146-
dc.identifier.eissn1097-0193-
dc.identifier.isiWOS:000353972000009-

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