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- Publisher Website: 10.1016/j.pnpbp.2010.03.032
- Scopus: eid_2-s2.0-77955052435
- PMID: 20363277
- WOS: WOS:000281187800005
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Article: The impact of early-onset cannabis use on functional brain correlates of working memory
Title | The impact of early-onset cannabis use on functional brain correlates of working memory |
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Authors | |
Keywords | Age of onset Cannabis FMRI Neuromaturation Parietal cortex Working memory |
Issue Date | 2010 |
Citation | Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2010, v. 34, n. 6, p. 837-845 How to Cite? |
Abstract | Cannabis is the most commonly used illicit drug. Prevalence rates are particularly high among adolescents. Neuropsychological studies have identified cannabis-associated memory deficits, particularly linked to an early onset of use. However, it remains unclear, whether the age of onset accounts for altered cortical activation patterns usually observed in cannabis users. Functional magnetic resonance imaging was used to examine cortical activation during verbal working memory challenge in (1) early-onset (onset before the age of sixteen; n= 26) and (2) late-onset cannabis users (age at onset at least sixteen; n= 17). Early-onset users showed increased activation in the left superior parietal lobe. Correlational analyses confirmed the association between an earlier start of use and increased activity. Contrariwise neither cumulative dose, frequency nor time since last use was significantly associated with cortical activity. Our findings suggest that an early start of cannabis use is associated with increased cortical activation in adult cannabis users, possibly reflecting suboptimal cortical efficiency during cognitive challenge. The maturing brain might be more vulnerable to the harmful effects of cannabis use. However, due to a lack of a non-using control group we cannot exclude alternative interpretations. © 2010 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/330354 |
ISSN | 2023 Impact Factor: 5.3 2023 SCImago Journal Rankings: 1.652 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Becker, Benjamin | - |
dc.contributor.author | Wagner, Daniel | - |
dc.contributor.author | Gouzoulis-Mayfrank, Euphrosyne | - |
dc.contributor.author | Spuentrup, Elmar | - |
dc.contributor.author | Daumann, Jörg | - |
dc.date.accessioned | 2023-09-05T12:09:52Z | - |
dc.date.available | 2023-09-05T12:09:52Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2010, v. 34, n. 6, p. 837-845 | - |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.uri | http://hdl.handle.net/10722/330354 | - |
dc.description.abstract | Cannabis is the most commonly used illicit drug. Prevalence rates are particularly high among adolescents. Neuropsychological studies have identified cannabis-associated memory deficits, particularly linked to an early onset of use. However, it remains unclear, whether the age of onset accounts for altered cortical activation patterns usually observed in cannabis users. Functional magnetic resonance imaging was used to examine cortical activation during verbal working memory challenge in (1) early-onset (onset before the age of sixteen; n= 26) and (2) late-onset cannabis users (age at onset at least sixteen; n= 17). Early-onset users showed increased activation in the left superior parietal lobe. Correlational analyses confirmed the association between an earlier start of use and increased activity. Contrariwise neither cumulative dose, frequency nor time since last use was significantly associated with cortical activity. Our findings suggest that an early start of cannabis use is associated with increased cortical activation in adult cannabis users, possibly reflecting suboptimal cortical efficiency during cognitive challenge. The maturing brain might be more vulnerable to the harmful effects of cannabis use. However, due to a lack of a non-using control group we cannot exclude alternative interpretations. © 2010 Elsevier Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Progress in Neuro-Psychopharmacology and Biological Psychiatry | - |
dc.subject | Age of onset | - |
dc.subject | Cannabis | - |
dc.subject | FMRI | - |
dc.subject | Neuromaturation | - |
dc.subject | Parietal cortex | - |
dc.subject | Working memory | - |
dc.title | The impact of early-onset cannabis use on functional brain correlates of working memory | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.pnpbp.2010.03.032 | - |
dc.identifier.pmid | 20363277 | - |
dc.identifier.scopus | eid_2-s2.0-77955052435 | - |
dc.identifier.volume | 34 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 837 | - |
dc.identifier.epage | 845 | - |
dc.identifier.isi | WOS:000281187800005 | - |