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Article: Neural signatures of default mode network in major depression disorder after electroconvulsive therapy

TitleNeural signatures of default mode network in major depression disorder after electroconvulsive therapy
Authors
Keywordsdefault mode network
electroconvulsive therapy
gene expression
major depressive disorder
prediction
Issue Date2023
Citation
Cerebral Cortex, 2023, v. 33, n. 7, p. 3840-3852 How to Cite?
AbstractFunctional abnormalities of default mode network (DMN) have been well documented in major depressive disorder (MDD). However, the association of DMN functional reorganization with antidepressant treatment and gene expression is unclear. Moreover, whether the functional interactions of DMN could predict treatment efficacy is also unknown. Here, we investigated the link of treatment response with functional alterations of DMN and gene expression with a comparably large sample including 46 individuals with MDD before and after electroconvulsive therapy (ECT) and 46 age- and sex-matched healthy controls. Static and dynamic functional connectivity (dFC) analyses showed increased intrinsic/static but decreased dynamic functional couplings of inter- and intrasubsystems and between nodes of DMN. The changes of static functional connections of DMN were spatially correlated with brain gene expression profiles. Moreover, static and dFC of the DMN before treatment as features could predict depressive symptom improvement following ECT. Taken together, these results shed light on the underlying neural and genetic basis of antidepressant effect of ECT and the intrinsic functional connectivity of DMN have the potential to serve as prognostic biomarkers to guide accurate personalized treatment.
Persistent Identifierhttp://hdl.handle.net/10722/330298
ISSN
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 1.685
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Yuanyuan-
dc.contributor.authorYu, Xiaohui-
dc.contributor.authorMa, Yingzi-
dc.contributor.authorSu, Jing-
dc.contributor.authorLi, Yue-
dc.contributor.authorZhu, Shunli-
dc.contributor.authorBai, Tongjian-
dc.contributor.authorWei, Qiang-
dc.contributor.authorBecker, Benjamin-
dc.contributor.authorDing, Zhiyong-
dc.contributor.authorWang, Kai-
dc.contributor.authorTian, Yanghua-
dc.contributor.authorWang, Jiaojian-
dc.date.accessioned2023-09-05T12:09:21Z-
dc.date.available2023-09-05T12:09:21Z-
dc.date.issued2023-
dc.identifier.citationCerebral Cortex, 2023, v. 33, n. 7, p. 3840-3852-
dc.identifier.issn1047-3211-
dc.identifier.urihttp://hdl.handle.net/10722/330298-
dc.description.abstractFunctional abnormalities of default mode network (DMN) have been well documented in major depressive disorder (MDD). However, the association of DMN functional reorganization with antidepressant treatment and gene expression is unclear. Moreover, whether the functional interactions of DMN could predict treatment efficacy is also unknown. Here, we investigated the link of treatment response with functional alterations of DMN and gene expression with a comparably large sample including 46 individuals with MDD before and after electroconvulsive therapy (ECT) and 46 age- and sex-matched healthy controls. Static and dynamic functional connectivity (dFC) analyses showed increased intrinsic/static but decreased dynamic functional couplings of inter- and intrasubsystems and between nodes of DMN. The changes of static functional connections of DMN were spatially correlated with brain gene expression profiles. Moreover, static and dFC of the DMN before treatment as features could predict depressive symptom improvement following ECT. Taken together, these results shed light on the underlying neural and genetic basis of antidepressant effect of ECT and the intrinsic functional connectivity of DMN have the potential to serve as prognostic biomarkers to guide accurate personalized treatment.-
dc.languageeng-
dc.relation.ispartofCerebral Cortex-
dc.subjectdefault mode network-
dc.subjectelectroconvulsive therapy-
dc.subjectgene expression-
dc.subjectmajor depressive disorder-
dc.subjectprediction-
dc.titleNeural signatures of default mode network in major depression disorder after electroconvulsive therapy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/cercor/bhac311-
dc.identifier.pmid36089839-
dc.identifier.scopuseid_2-s2.0-85151575692-
dc.identifier.volume33-
dc.identifier.issue7-
dc.identifier.spage3840-
dc.identifier.epage3852-
dc.identifier.eissn1460-2199-
dc.identifier.isiWOS:000853182900001-

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