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- Publisher Website: 10.1016/j.fmre.2022.06.001
- Scopus: eid_2-s2.0-85132906155
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Article: Ternary NiCoTi-layered double hydroxide nanosheets as a pH-responsive nanoagent for photodynamic/chemodynamic synergistic therapy
Title | Ternary NiCoTi-layered double hydroxide nanosheets as a pH-responsive nanoagent for photodynamic/chemodynamic synergistic therapy |
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Authors | |
Keywords | Chemodynamic therapy Layered double hydroxides Oxygen vacancy pH-responsive Photodynamic therapy |
Issue Date | 2022 |
Citation | Fundamental Research, 2022 How to Cite? |
Abstract | Combining photodynamic therapy (PDT) with chemodynamic therapy (CDT) has been proven to be a promising strategy to improve the treatment efficiency of cancer, because of the synergistic therapeutic effect arising between the two modalities. Herein, we report an inorganic nanoagent based on ternary NiCoTi-layered double hydroxide (NiCoTi-LDH) nanosheets to realize highly efficient photodynamic/chemodynamic synergistic therapy. The NiCoTi-LDH nanosheets exhibit oxygen vacancy-promoted electron-hole separation and photogenerated hole-induced O2-independent reactive oxygen species (ROS) generation under acidic circumstances, realizing in situ pH-responsive PDT. Moreover, due to the effective conversion between Co3+ and Co2+ caused by photogenerated electrons, the NiCoTi-LDH nanosheets catalyze the release of hydroxyl radicals (∙OH) from H2O2 through Fenton reactions, resulting in CDT. Laser irradiation enhances the catalyzed ability of the NiCoTi-LDH nanosheets to promote the ROS generation, resulting in a better performance than TiO2 nanoparticles at pH 6.5. In vitro and in vivo experimental results show conclusively that NiCoTi-LDH nanosheets plus irradiation lead to efficient cell apoptosis and significant inhibition of tumor growth. This study reports a new pH-responsive inorganic nanoagent with oxygen vacancy-promoted photodynamic/chemodynamic synergistic performance, offering a potentially appealing clinical strategy for selective tumor elimination. |
Persistent Identifier | http://hdl.handle.net/10722/329864 |
DC Field | Value | Language |
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dc.contributor.author | Hu, Tingting | - |
dc.contributor.author | Zhou, Zhan | - |
dc.contributor.author | Zha, Jiajia | - |
dc.contributor.author | Williams, Gareth R. | - |
dc.contributor.author | Wu, Zhikang | - |
dc.contributor.author | Zhao, Wei | - |
dc.contributor.author | Shen, Weicheng | - |
dc.contributor.author | Li, Hai | - |
dc.contributor.author | Weng, Xisheng | - |
dc.contributor.author | Liang, Ruizheng | - |
dc.contributor.author | Tan, Chaoliang | - |
dc.date.accessioned | 2023-08-09T03:35:54Z | - |
dc.date.available | 2023-08-09T03:35:54Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Fundamental Research, 2022 | - |
dc.identifier.uri | http://hdl.handle.net/10722/329864 | - |
dc.description.abstract | Combining photodynamic therapy (PDT) with chemodynamic therapy (CDT) has been proven to be a promising strategy to improve the treatment efficiency of cancer, because of the synergistic therapeutic effect arising between the two modalities. Herein, we report an inorganic nanoagent based on ternary NiCoTi-layered double hydroxide (NiCoTi-LDH) nanosheets to realize highly efficient photodynamic/chemodynamic synergistic therapy. The NiCoTi-LDH nanosheets exhibit oxygen vacancy-promoted electron-hole separation and photogenerated hole-induced O2-independent reactive oxygen species (ROS) generation under acidic circumstances, realizing in situ pH-responsive PDT. Moreover, due to the effective conversion between Co3+ and Co2+ caused by photogenerated electrons, the NiCoTi-LDH nanosheets catalyze the release of hydroxyl radicals (∙OH) from H2O2 through Fenton reactions, resulting in CDT. Laser irradiation enhances the catalyzed ability of the NiCoTi-LDH nanosheets to promote the ROS generation, resulting in a better performance than TiO2 nanoparticles at pH 6.5. In vitro and in vivo experimental results show conclusively that NiCoTi-LDH nanosheets plus irradiation lead to efficient cell apoptosis and significant inhibition of tumor growth. This study reports a new pH-responsive inorganic nanoagent with oxygen vacancy-promoted photodynamic/chemodynamic synergistic performance, offering a potentially appealing clinical strategy for selective tumor elimination. | - |
dc.language | eng | - |
dc.relation.ispartof | Fundamental Research | - |
dc.subject | Chemodynamic therapy | - |
dc.subject | Layered double hydroxides | - |
dc.subject | Oxygen vacancy | - |
dc.subject | pH-responsive | - |
dc.subject | Photodynamic therapy | - |
dc.title | Ternary NiCoTi-layered double hydroxide nanosheets as a pH-responsive nanoagent for photodynamic/chemodynamic synergistic therapy | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.fmre.2022.06.001 | - |
dc.identifier.scopus | eid_2-s2.0-85132906155 | - |
dc.identifier.eissn | 2667-3258 | - |