File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1038/s41467-022-31106-9
- Scopus: eid_2-s2.0-85131790719
- PMID: 35697679
- WOS: WOS:000810727500019
Supplementary
- Citations:
- Appears in Collections:
Article: Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy
Title | Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy |
---|---|
Authors | |
Issue Date | 2022 |
Citation | Nature Communications, 2022, v. 13, n. 1, article no. 3384 How to Cite? |
Abstract | Although two-dimensional (2D) layered double hydroxides (LDHs) have been widely used as efficient nanoagents for biological diagnosis and treatment, they have been found to be inert as photosensitizers (PSs) for photodynamic therapy (PDT). Herein, we report the defect engineering of ultrathin 2D CoMo-LDH and NiMo-LDH nanosheets as highly active inorganic PSs for PDT in the third near-infrared (NIR-III) window. Hydrothermal-synthesized 2D CoMo-LDH and NiMo-LDH nanosheets are etched via a simple acid treatment to obtain defect-rich CoMo-LDH and NiMo-LDH nanosheets. Importantly, the defect-rich CoMo-LDH nanosheets exhibit much higher activity (~97 times) for generation of reactive oxygen species than that of the pristine CoMo-LDH nanosheets under a NIR-III 1567 nm laser irradiation. Therefore, after modification with polyethylene glycol, the defect-rich CoMo-LDH nanosheets can be used as an efficient inorganic PS for PDT to efficiently induce cancer cells apoptosis in vitro and eradicate tumors in vivo under 1567 nm laser irradiation. |
Persistent Identifier | http://hdl.handle.net/10722/329857 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shen, Weicheng | - |
dc.contributor.author | Hu, Tingting | - |
dc.contributor.author | Liu, Xueyan | - |
dc.contributor.author | Zha, Jiajia | - |
dc.contributor.author | Meng, Fanqi | - |
dc.contributor.author | Wu, Zhikang | - |
dc.contributor.author | Cui, Zhuolin | - |
dc.contributor.author | Yang, Yu | - |
dc.contributor.author | Li, Hai | - |
dc.contributor.author | Zhang, Qinghua | - |
dc.contributor.author | Gu, Lin | - |
dc.contributor.author | Liang, Ruizheng | - |
dc.contributor.author | Tan, Chaoliang | - |
dc.date.accessioned | 2023-08-09T03:35:51Z | - |
dc.date.available | 2023-08-09T03:35:51Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Nature Communications, 2022, v. 13, n. 1, article no. 3384 | - |
dc.identifier.uri | http://hdl.handle.net/10722/329857 | - |
dc.description.abstract | Although two-dimensional (2D) layered double hydroxides (LDHs) have been widely used as efficient nanoagents for biological diagnosis and treatment, they have been found to be inert as photosensitizers (PSs) for photodynamic therapy (PDT). Herein, we report the defect engineering of ultrathin 2D CoMo-LDH and NiMo-LDH nanosheets as highly active inorganic PSs for PDT in the third near-infrared (NIR-III) window. Hydrothermal-synthesized 2D CoMo-LDH and NiMo-LDH nanosheets are etched via a simple acid treatment to obtain defect-rich CoMo-LDH and NiMo-LDH nanosheets. Importantly, the defect-rich CoMo-LDH nanosheets exhibit much higher activity (~97 times) for generation of reactive oxygen species than that of the pristine CoMo-LDH nanosheets under a NIR-III 1567 nm laser irradiation. Therefore, after modification with polyethylene glycol, the defect-rich CoMo-LDH nanosheets can be used as an efficient inorganic PS for PDT to efficiently induce cancer cells apoptosis in vitro and eradicate tumors in vivo under 1567 nm laser irradiation. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature Communications | - |
dc.title | Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/s41467-022-31106-9 | - |
dc.identifier.pmid | 35697679 | - |
dc.identifier.scopus | eid_2-s2.0-85131790719 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 3384 | - |
dc.identifier.epage | article no. 3384 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.isi | WOS:000810727500019 | - |