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- Publisher Website: 10.1016/j.cej.2021.129458
- Scopus: eid_2-s2.0-85103723264
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Article: Ultrathin CuFe2 S3 nanosheets derived from CuFe-layered double hydroxide as an efficient nanoagent for synergistic chemodynamic and NIR-II photothermal therapy
Title | Ultrathin CuFe<inf>2</inf>S<inf>3</inf> nanosheets derived from CuFe-layered double hydroxide as an efficient nanoagent for synergistic chemodynamic and NIR-II photothermal therapy |
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Authors | |
Keywords | Chemodynamic therapy CuFe S nanosheets 2 3 NIR-II photothermal therapy Synergistic therapy |
Issue Date | 2021 |
Citation | Chemical Engineering Journal, 2021, v. 419, article no. 129458 How to Cite? |
Abstract | Ultrathin two-dimensional (2D) nanosheets (NSs) have been widely explored as nanoagents for multimodal cancer therapies, such as photothermal therapy (PTT) combined with chemodynamic therapy (CDT). However, it is still a challenge to prepare 2D NSs with good performance in both CDT and NIR-II PTT. Here, we report the preparation of ultrathin 2D CuFe2S3 NSs as an efficient nanoagent for synergistic CDT and NIR-II PTT to ablate cancer cells/tumors. Ultrathin 2D CuFe2S3 NSs are first prepared by sulfurization of ultrathin CuFe-LDH NSs via a simple hydrothermal treatment. After modification with polyethylene glycol (PEG), the PEG-modified CuFe2S3 NSs (CuFe2S3-PEG) show broadband NIR-II absorption and excellent photothermal conversion efficiency (~55.86%) at 1064 nm. Moreover, the overproduced glutathione in the tumor microenvironment can react with CuFe2S3-PEG NSs to release Fe2+ and Cu+, thus activating Fenton reaction to efficiently produce hydroxyl radicals (·OH). Importantly, the photothermal effect of CuFe2S3-PEG could further synergistically improve the Fenton reaction by increasing the local temperature. In vitro and in vivo results reveal that the CuFe2S3-PEG has remarkable synergistic CDT/PTT antitumor activity. This study has proven that the metal chalcogenide NSs of CuFe2S3-PEG can be used as an efficient nanoagent for multimodal cancer therapies, which could also be promising in other applications like biosensors, drug delivery and antibacterial. |
Persistent Identifier | http://hdl.handle.net/10722/329699 |
ISSN | 2023 Impact Factor: 13.3 2023 SCImago Journal Rankings: 2.852 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wang, Sa | - |
dc.contributor.author | Hu, Tingting | - |
dc.contributor.author | Wang, Guanyun | - |
dc.contributor.author | Wang, Zhengdi | - |
dc.contributor.author | Yan, Dan | - |
dc.contributor.author | Liang, Ruizheng | - |
dc.contributor.author | Tan, Chaoliang | - |
dc.date.accessioned | 2023-08-09T03:34:41Z | - |
dc.date.available | 2023-08-09T03:34:41Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Chemical Engineering Journal, 2021, v. 419, article no. 129458 | - |
dc.identifier.issn | 1385-8947 | - |
dc.identifier.uri | http://hdl.handle.net/10722/329699 | - |
dc.description.abstract | Ultrathin two-dimensional (2D) nanosheets (NSs) have been widely explored as nanoagents for multimodal cancer therapies, such as photothermal therapy (PTT) combined with chemodynamic therapy (CDT). However, it is still a challenge to prepare 2D NSs with good performance in both CDT and NIR-II PTT. Here, we report the preparation of ultrathin 2D CuFe2S3 NSs as an efficient nanoagent for synergistic CDT and NIR-II PTT to ablate cancer cells/tumors. Ultrathin 2D CuFe2S3 NSs are first prepared by sulfurization of ultrathin CuFe-LDH NSs via a simple hydrothermal treatment. After modification with polyethylene glycol (PEG), the PEG-modified CuFe2S3 NSs (CuFe2S3-PEG) show broadband NIR-II absorption and excellent photothermal conversion efficiency (~55.86%) at 1064 nm. Moreover, the overproduced glutathione in the tumor microenvironment can react with CuFe2S3-PEG NSs to release Fe2+ and Cu+, thus activating Fenton reaction to efficiently produce hydroxyl radicals (·OH). Importantly, the photothermal effect of CuFe2S3-PEG could further synergistically improve the Fenton reaction by increasing the local temperature. In vitro and in vivo results reveal that the CuFe2S3-PEG has remarkable synergistic CDT/PTT antitumor activity. This study has proven that the metal chalcogenide NSs of CuFe2S3-PEG can be used as an efficient nanoagent for multimodal cancer therapies, which could also be promising in other applications like biosensors, drug delivery and antibacterial. | - |
dc.language | eng | - |
dc.relation.ispartof | Chemical Engineering Journal | - |
dc.subject | Chemodynamic therapy | - |
dc.subject | CuFe S nanosheets 2 3 | - |
dc.subject | NIR-II photothermal therapy | - |
dc.subject | Synergistic therapy | - |
dc.title | Ultrathin CuFe<inf>2</inf>S<inf>3</inf> nanosheets derived from CuFe-layered double hydroxide as an efficient nanoagent for synergistic chemodynamic and NIR-II photothermal therapy | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.cej.2021.129458 | - |
dc.identifier.scopus | eid_2-s2.0-85103723264 | - |
dc.identifier.volume | 419 | - |
dc.identifier.spage | article no. 129458 | - |
dc.identifier.epage | article no. 129458 | - |
dc.identifier.isi | WOS:000663660000001 | - |