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Article: Activating Layered Metal Oxide Nanomaterials via Structural Engineering as Biodegradable Nanoagents for Photothermal Cancer Therapy

TitleActivating Layered Metal Oxide Nanomaterials via Structural Engineering as Biodegradable Nanoagents for Photothermal Cancer Therapy
Authors
Keywordsbiodegradable nanoagents
layered metal oxides
near-infrared-II window
photothermal therapy
structural engineering
Issue Date2021
Citation
Small, 2021, v. 17, n. 12, article no. 2007486 How to Cite?
AbstractLayered metal oxides including MoO3 and WO3 have been widely explored for biological applications owing to their excellent biocompatibility, low toxicity, and easy preparation. However, they normally exhibit weak or negligible near-infrared (NIR) absorption and thus are inefficient for photo-induced biomedical applications. Herein, the structural engineering of layered MoO3 and WO3 nanostructures is first reported to activate their NIR-II absorption for efficient photothermal cancer therapy in the NIR-II window. White-colored micrometre-long MoO3 nanobelts are transformed into blue-colored short, thin, defective, interlayer gap-expanded MoO3−x nanobelts with a strong NIR-II absorption via the simple lithium treatment. The blue MoO3−x nanobelts exhibit a large extinction coefficient of 18.2 L g−1 cm−1 and high photothermal conversion efficiency of 46.9% at 1064 nm. After surface modification, the MoO3−x nanobelts can be used as a robust nanoagent for photoacoustic imaging-guided photothermal therapy to achieve efficient cancer cell ablation and tumor eradication under irradiation by a 1064 nm laser. Importantly, the biodegradable MoO3−x nanobelts can be rapidly degraded and excreted from body. The study highlights that the structural engineering of layered metal oxides is a powerful strategy to tune their properties and thus boost their performances in given applications.
Persistent Identifierhttp://hdl.handle.net/10722/329683
ISSN
2023 Impact Factor: 13.0
2023 SCImago Journal Rankings: 3.348
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Zhan-
dc.contributor.authorWang, Xianwen-
dc.contributor.authorZhang, Hui-
dc.contributor.authorHuang, Haoxin-
dc.contributor.authorSun, Lina-
dc.contributor.authorMa, Lu-
dc.contributor.authorDu, Yonghua-
dc.contributor.authorPei, Chengjie-
dc.contributor.authorZhang, Qinghua-
dc.contributor.authorLi, Hai-
dc.contributor.authorMa, Lufang-
dc.contributor.authorGu, Lin-
dc.contributor.authorLiu, Zhuang-
dc.contributor.authorCheng, Liang-
dc.contributor.authorTan, Chaoliang-
dc.date.accessioned2023-08-09T03:34:34Z-
dc.date.available2023-08-09T03:34:34Z-
dc.date.issued2021-
dc.identifier.citationSmall, 2021, v. 17, n. 12, article no. 2007486-
dc.identifier.issn1613-6810-
dc.identifier.urihttp://hdl.handle.net/10722/329683-
dc.description.abstractLayered metal oxides including MoO3 and WO3 have been widely explored for biological applications owing to their excellent biocompatibility, low toxicity, and easy preparation. However, they normally exhibit weak or negligible near-infrared (NIR) absorption and thus are inefficient for photo-induced biomedical applications. Herein, the structural engineering of layered MoO3 and WO3 nanostructures is first reported to activate their NIR-II absorption for efficient photothermal cancer therapy in the NIR-II window. White-colored micrometre-long MoO3 nanobelts are transformed into blue-colored short, thin, defective, interlayer gap-expanded MoO3−x nanobelts with a strong NIR-II absorption via the simple lithium treatment. The blue MoO3−x nanobelts exhibit a large extinction coefficient of 18.2 L g−1 cm−1 and high photothermal conversion efficiency of 46.9% at 1064 nm. After surface modification, the MoO3−x nanobelts can be used as a robust nanoagent for photoacoustic imaging-guided photothermal therapy to achieve efficient cancer cell ablation and tumor eradication under irradiation by a 1064 nm laser. Importantly, the biodegradable MoO3−x nanobelts can be rapidly degraded and excreted from body. The study highlights that the structural engineering of layered metal oxides is a powerful strategy to tune their properties and thus boost their performances in given applications.-
dc.languageeng-
dc.relation.ispartofSmall-
dc.subjectbiodegradable nanoagents-
dc.subjectlayered metal oxides-
dc.subjectnear-infrared-II window-
dc.subjectphotothermal therapy-
dc.subjectstructural engineering-
dc.titleActivating Layered Metal Oxide Nanomaterials via Structural Engineering as Biodegradable Nanoagents for Photothermal Cancer Therapy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/smll.202007486-
dc.identifier.pmid33590671-
dc.identifier.scopuseid_2-s2.0-85101105172-
dc.identifier.volume17-
dc.identifier.issue12-
dc.identifier.spagearticle no. 2007486-
dc.identifier.epagearticle no. 2007486-
dc.identifier.eissn1613-6829-
dc.identifier.isiWOS:000618234700001-

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