File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)

Article: Effectiveness of BNT162b2 and CoronaVac vaccines in preventing SARS-CoV-2 Omicron infections, hospitalizations, and severe complications in the pediatric population in Hong Kong: a case-control study

TitleEffectiveness of BNT162b2 and CoronaVac vaccines in preventing SARS-CoV-2 Omicron infections, hospitalizations, and severe complications in the pediatric population in Hong Kong: a case-control study
Authors
KeywordsCOVID-19
inactivated vaccine
mRNA vaccine
pediatric population
vaccine effectiveness
Issue Date31-Dec-2023
PublisherTaylor and Francis Group
Citation
Emerging Microbes & Infections, 2023, v. 12, n. 1 How to Cite?
Abstract

Severe COVID-19 appears to be disproportionately more common in children and adolescents since the emergence of Omicron. More evidence regarding vaccine effectiveness (VE) is urgently needed to assist policymakers in making decisions and minimize vaccine hesitancy among the public. This was a case-control study in the pediatric population using data extracted from the electronic health records database in Hong Kong. Individuals aged 3–17 with COVID-19 confirmed by polymerase chain reaction were included in the study. Each case was matched with up to 10 controls based on age, gender, and index date (within 3 calendar days). The VE of BNT162b2 and CoronaVac in preventing COVID-19, hospitalizations, and severe outcomes were estimated using conditional logistic regression adjusted by patients’ comorbidities and medication history during the outbreak from January to August 2022. A total of 36,434 COVID-19 cases, 2231 COVID-19-related hospitalizations, and 1918 severe COVID-19 cases were matched to 109,004, 21,788, and 18,823 controls, respectively. Compared to the unvaccinated group, three doses of BNT162b2 or CoronaVac was associated with reduced risk of infection [VE: BNT162b2: 56.0% (95% CI: 49.6–61.6), CoronaVac: 39.4% (95% CI: 25.6–50.6)], hospitalization [VE: BNT162b2: 58.9% (95% CI: 36.1–73.6), CoronaVac: 51.7% (11.6–73.6)], and severe outcomes [VE: BNT162b2: 60.2% (95% CI: 33.7–76.1), CoronaVac: 42.2% (95% CI: −6.2–68.6)]. Our findings showed that three doses of BNT162b2 or CoronaVac was effective in preventing COVID-19, hospitalizations, and severe outcomes among the pediatric population during Omicron-dominant pandemic, which was further enhanced after a booster dose.


Persistent Identifierhttp://hdl.handle.net/10722/329206
ISSN
2023 Impact Factor: 8.4
2023 SCImago Journal Rankings: 2.316
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYan, VKC-
dc.contributor.authorCheng, FWT-
dc.contributor.authorChui, CSL-
dc.contributor.authorLai, FTT-
dc.contributor.authorWong, CKH-
dc.contributor.authorLi, X-
dc.contributor.authorWan, EYF-
dc.contributor.authorWong, JSC-
dc.contributor.authorChan, EWY-
dc.contributor.authorWong, ICK-
dc.contributor.authorKwan, MYW-
dc.contributor.authorIp, P-
dc.date.accessioned2023-08-05T07:56:05Z-
dc.date.available2023-08-05T07:56:05Z-
dc.date.issued2023-12-31-
dc.identifier.citationEmerging Microbes & Infections, 2023, v. 12, n. 1-
dc.identifier.issn2222-1751-
dc.identifier.urihttp://hdl.handle.net/10722/329206-
dc.description.abstract<p>Severe COVID-19 appears to be disproportionately more common in children and adolescents since the emergence of Omicron. More evidence regarding vaccine effectiveness (VE) is urgently needed to assist policymakers in making decisions and minimize vaccine hesitancy among the public. This was a case-control study in the pediatric population using data extracted from the electronic health records database in Hong Kong. Individuals aged 3–17 with COVID-19 confirmed by polymerase chain reaction were included in the study. Each case was matched with up to 10 controls based on age, gender, and index date (within 3 calendar days). The VE of BNT162b2 and CoronaVac in preventing COVID-19, hospitalizations, and severe outcomes were estimated using conditional logistic regression adjusted by patients’ comorbidities and medication history during the outbreak from January to August 2022. A total of 36,434 COVID-19 cases, 2231 COVID-19-related hospitalizations, and 1918 severe COVID-19 cases were matched to 109,004, 21,788, and 18,823 controls, respectively. Compared to the unvaccinated group, three doses of BNT162b2 or CoronaVac was associated with reduced risk of infection [VE: BNT162b2: 56.0% (95% CI: 49.6–61.6), CoronaVac: 39.4% (95% CI: 25.6–50.6)], hospitalization [VE: BNT162b2: 58.9% (95% CI: 36.1–73.6), CoronaVac: 51.7% (11.6–73.6)], and severe outcomes [VE: BNT162b2: 60.2% (95% CI: 33.7–76.1), CoronaVac: 42.2% (95% CI: −6.2–68.6)]. Our findings showed that three doses of BNT162b2 or CoronaVac was effective in preventing COVID-19, hospitalizations, and severe outcomes among the pediatric population during Omicron-dominant pandemic, which was further enhanced after a booster dose.</p>-
dc.languageeng-
dc.publisherTaylor and Francis Group-
dc.relation.ispartofEmerging Microbes & Infections-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCOVID-19-
dc.subjectinactivated vaccine-
dc.subjectmRNA vaccine-
dc.subjectpediatric population-
dc.subjectvaccine effectiveness-
dc.titleEffectiveness of BNT162b2 and CoronaVac vaccines in preventing SARS-CoV-2 Omicron infections, hospitalizations, and severe complications in the pediatric population in Hong Kong: a case-control study-
dc.typeArticle-
dc.identifier.doi10.1080/22221751.2023.2185455-
dc.identifier.scopuseid_2-s2.0-85150311267-
dc.identifier.volume12-
dc.identifier.issue1-
dc.identifier.eissn2222-1751-
dc.identifier.isiWOS:000950078800001-
dc.identifier.issnl2222-1751-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats