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Article: On-Off Phagocytosis and Switchable Macrophage Activation Stimulated with NIR for Infected Percutaneous Tissue Repair of Polypyrrole-Coated Sulfonated PEEK

TitleOn-Off Phagocytosis and Switchable Macrophage Activation Stimulated with NIR for Infected Percutaneous Tissue Repair of Polypyrrole-Coated Sulfonated PEEK
Authors
Keywordscomplement
macrophage activation
on-off phagocytosis
polyether ether ketone
Issue Date14-Dec-2022
PublisherWiley Open Access
Citation
Advanced Science, 2023, v. 10, n. 5 How to Cite?
AbstractIntelligent control of the immune response is essential for obtaining percutaneous implants with good sterilization and tissue repair abilities. In this study, polypyrrole (Ppy) nanoparticles enveloping a 3D frame of sulfonated polyether ether ketone (SP) surface are constructed, which enhance the surface modulus and hardness of the sulfonated layer by forming a cooperative structure of simulated reinforced concrete and exhibit a superior photothermal effect. Ppy-coated SP could quickly accumulate heat on the surface by responding to 808 nm near-infrared (NIR) light, thereby killing bacteria, and destroying biofilms. Under NIR stimulation, the phagocytosis and M1 activation of macrophages cultured on Ppy-coated SP are enhanced by activating complement 3 and its receptor, CD11b. Phagocytosis and M1 activation are impaired along with abolishment of NIR stimulation in the Ppy-coated SP group, which is favorable for tissue repair. Ppy-coated SP promotes Collagen-I, vascular endothelial growth factor, connective tissue growth factor, and α-actin (Acta2) expression by inducing M2 polarization owing to its higher surface modulus. Overall, Ppy-coated SP with enhanced mechanical properties could be a good candidate for clinical percutaneous implants through on-off phagocytosis and switchable macrophage activation stimulated with NIR.
Persistent Identifierhttp://hdl.handle.net/10722/329202
ISSN
2023 Impact Factor: 14.3
2023 SCImago Journal Rankings: 3.914
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, XD-
dc.contributor.authorZhang, HF-
dc.contributor.authorYan, BC-
dc.contributor.authorYeung, KWK-
dc.contributor.authorLiao, Y-
dc.contributor.authorOuyang, LP-
dc.contributor.authorLiu, XY-
dc.date.accessioned2023-08-05T07:56:04Z-
dc.date.available2023-08-05T07:56:04Z-
dc.date.issued2022-12-14-
dc.identifier.citationAdvanced Science, 2023, v. 10, n. 5-
dc.identifier.issn2198-3844-
dc.identifier.urihttp://hdl.handle.net/10722/329202-
dc.description.abstractIntelligent control of the immune response is essential for obtaining percutaneous implants with good sterilization and tissue repair abilities. In this study, polypyrrole (Ppy) nanoparticles enveloping a 3D frame of sulfonated polyether ether ketone (SP) surface are constructed, which enhance the surface modulus and hardness of the sulfonated layer by forming a cooperative structure of simulated reinforced concrete and exhibit a superior photothermal effect. Ppy-coated SP could quickly accumulate heat on the surface by responding to 808 nm near-infrared (NIR) light, thereby killing bacteria, and destroying biofilms. Under NIR stimulation, the phagocytosis and M1 activation of macrophages cultured on Ppy-coated SP are enhanced by activating complement 3 and its receptor, CD11b. Phagocytosis and M1 activation are impaired along with abolishment of NIR stimulation in the Ppy-coated SP group, which is favorable for tissue repair. Ppy-coated SP promotes Collagen-I, vascular endothelial growth factor, connective tissue growth factor, and α-actin (Acta2) expression by inducing M2 polarization owing to its higher surface modulus. Overall, Ppy-coated SP with enhanced mechanical properties could be a good candidate for clinical percutaneous implants through on-off phagocytosis and switchable macrophage activation stimulated with NIR.-
dc.languageeng-
dc.publisherWiley Open Access-
dc.relation.ispartofAdvanced Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcomplement-
dc.subjectmacrophage activation-
dc.subjecton-off phagocytosis-
dc.subjectpolyether ether ketone-
dc.titleOn-Off Phagocytosis and Switchable Macrophage Activation Stimulated with NIR for Infected Percutaneous Tissue Repair of Polypyrrole-Coated Sulfonated PEEK-
dc.typeArticle-
dc.identifier.doi10.1002/advs.202205048-
dc.identifier.scopuseid_2-s2.0-85144134198-
dc.identifier.volume10-
dc.identifier.issue5-
dc.identifier.eissn2198-3844-
dc.identifier.isiWOS:000898108300001-
dc.identifier.issnl2198-3844-

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