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Article: Reward motivation adaptation in people with negative schizotypal features: development of a novel behavioural paradigm and identifying its neural correlates using resting-state functional connectivity analysis

TitleReward motivation adaptation in people with negative schizotypal features: development of a novel behavioural paradigm and identifying its neural correlates using resting-state functional connectivity analysis
Authors
KeywordsEffort-reward imbalance
Negative schizotypal traits
Resting-state functional connectivity
Reward motivation
Issue Date3-Jul-2023
PublisherSpringer
Citation
European Archives of Psychiatry and Clinical Neuroscience, 2023 How to Cite?
Abstract

Reward motivation in individuals with high levels of negative schizotypal traits (NS) has been found to be lower than that in their counterparts. But it is unclear that whether their reward motivation adaptively changes with external effort-reward ratio, and what resting-state functional connectivity (rsFC) is associated with this change. Thirty-five individuals with high levels of NS and 44 individuals with low levels of NS were recruited. A 3T resting-state functional brain scan and a novel reward motivation adaptation behavioural task were administrated in all participants. The behavioural task was manipulated with three conditions (effort > reward condition vs. effort < reward condition vs. effort = reward condition). Under each condition were rated 'wanting' and 'liking' for rewards. The seed-based voxel-wise rsFC analysis was conducted to explore the rsFCs associated with the 'wanting' and 'liking' ratings in individuals with high levels of NS. 'Wanting' and 'liking' ratings of individuals with high levels of NS significantly declined in the effort > reward condition but did not rebound as high as their counterparts in the effort < reward condition. The rsFCs in NS group associated with these ratings were altered. The altered rsFCs in NS group involved regions in the prefrontal lobe, dopaminergic brain regions (ventral tegmental area, substantia nigra), hippocampus, thalamus and cerebellum. Individuals with high levels of NS manifested their reward motivation adaptation impairment as a failure of adjustment adaptively during effort-reward imbalance condition and altered rsFCs in prefrontal, dopaminergic and other brain regions.


Persistent Identifierhttp://hdl.handle.net/10722/329156
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 1.381
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYan, YJ-
dc.contributor.authorHu, HX-
dc.contributor.authorZhang, YJ-
dc.contributor.authorWang, LL-
dc.contributor.authorPan, YM-
dc.contributor.authorLui, SSY-
dc.contributor.authorHuang, J-
dc.contributor.authorChan, RCK-
dc.date.accessioned2023-08-05T07:55:43Z-
dc.date.available2023-08-05T07:55:43Z-
dc.date.issued2023-07-03-
dc.identifier.citationEuropean Archives of Psychiatry and Clinical Neuroscience, 2023-
dc.identifier.issn0940-1334-
dc.identifier.urihttp://hdl.handle.net/10722/329156-
dc.description.abstract<p>Reward motivation in individuals with high levels of negative schizotypal traits (NS) has been found to be lower than that in their counterparts. But it is unclear that whether their reward motivation adaptively changes with external effort-reward ratio, and what resting-state functional connectivity (rsFC) is associated with this change. Thirty-five individuals with high levels of NS and 44 individuals with low levels of NS were recruited. A 3T resting-state functional brain scan and a novel reward motivation adaptation behavioural task were administrated in all participants. The behavioural task was manipulated with three conditions (effort > reward condition vs. effort < reward condition vs. effort = reward condition). Under each condition were rated 'wanting' and 'liking' for rewards. The seed-based voxel-wise rsFC analysis was conducted to explore the rsFCs associated with the 'wanting' and 'liking' ratings in individuals with high levels of NS. 'Wanting' and 'liking' ratings of individuals with high levels of NS significantly declined in the effort > reward condition but did not rebound as high as their counterparts in the effort < reward condition. The rsFCs in NS group associated with these ratings were altered. The altered rsFCs in NS group involved regions in the prefrontal lobe, dopaminergic brain regions (ventral tegmental area, substantia nigra), hippocampus, thalamus and cerebellum. Individuals with high levels of NS manifested their reward motivation adaptation impairment as a failure of adjustment adaptively during effort-reward imbalance condition and altered rsFCs in prefrontal, dopaminergic and other brain regions.</p>-
dc.languageeng-
dc.publisherSpringer-
dc.relation.ispartofEuropean Archives of Psychiatry and Clinical Neuroscience-
dc.subjectEffort-reward imbalance-
dc.subjectNegative schizotypal traits-
dc.subjectResting-state functional connectivity-
dc.subjectReward motivation-
dc.titleReward motivation adaptation in people with negative schizotypal features: development of a novel behavioural paradigm and identifying its neural correlates using resting-state functional connectivity analysis-
dc.typeArticle-
dc.identifier.doi10.1007/s00406-023-01640-8-
dc.identifier.pmid37395812-
dc.identifier.scopuseid_2-s2.0-85163750642-
dc.identifier.eissn1433-8491-
dc.identifier.isiWOS:001021357600001-
dc.identifier.issnl0940-1334-

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