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Article: Consensus Statements on Precision Oncology in the China Greater Bay Area

TitleConsensus Statements on Precision Oncology in the China Greater Bay Area
Authors
Issue Date14-Jun-2023
PublisherAmerican Society of Clinical Oncology
Citation
JCO Precision Oncology, 2023 How to Cite?
Abstract

Background: Next-generation sequencing comprehensive genomic panels (NGS CGPs) have enabled the delivery of tailor-made therapeutic approaches to improve survival outcomes in patients with cancer. Within the China Greater Bay Area (GBA), territorial differences in clinical practices and health care systems and strengthening collaboration warrant a regional consensus to consolidate the development and integration of precision oncology (PO). Therefore, the Precision Oncology Working Group (POWG) formulated standardized principles for the clinical application of molecular profiling, interpretation of genomic alterations, and alignment of actionable mutations with sequence-directed therapy to deliver clinical services of excellence and evidence-based care to patients with cancer in the China GBA.

Methods: Thirty experts used a modified Delphi method. The evidence extracted to support the statements was graded according to the GRADE system and reported according to the Revised Standards for Quality Improvement Reporting Excellence guidelines, version 2.0.

Results: The POWG reached consensus in six key statements: harmonization of reporting and quality assurance of NGS; molecular tumor board and clinical decision support systems for PO; education and training; research and real-world data collection, patient engagement, regulations, and financial reimbursement of PO treatment strategies; and clinical recommendations and implementation of PO in clinical practice.

Conclusion: POWG consensus statements standardize the clinical application of NGS CGPs, streamline the interpretation of clinically significant genomic alterations, and align actionable mutations with sequence-directed therapies. The POWG consensus statements may harmonize the utility and delivery of PO in China's GBA.


Persistent Identifierhttp://hdl.handle.net/10722/329133
ISSN
2023 Impact Factor: 5.3
2023 SCImago Journal Rankings: 2.249

 

DC FieldValueLanguage
dc.contributor.authorLam, TC-
dc.contributor.authorCho, WC-
dc.contributor.authorAu, JS-
dc.contributor.authorMa, ES-
dc.contributor.authorLam, ST-
dc.contributor.authorLoong, HH-
dc.contributor.authorWong, JWH-
dc.contributor.authorWong, SNM-
dc.contributor.authorLee, VH-
dc.contributor.authorLeung, RC-
dc.contributor.authorLau, JK-
dc.contributor.authorKam, MT-
dc.contributor.authorMok, FS-
dc.contributor.authorLim, FM-
dc.contributor.authorNyaw, JS-
dc.contributor.authorTin, WW-
dc.contributor.authorCheung, KM-
dc.contributor.authorChan, OS-
dc.contributor.authorKwong, PW-
dc.contributor.authorCheung, FY-
dc.contributor.authorPoon, DMC-
dc.contributor.authorChik, JY-
dc.contributor.authorLam, MH-
dc.contributor.authorChan, LW-
dc.contributor.authorWong, SC-
dc.contributor.authorCao, YB-
dc.contributor.authorHui, CV-
dc.contributor.authorChen, JZ-
dc.contributor.authorChang, JH-
dc.contributor.authorKong, SF-
dc.contributor.authorEl Helali, A-
dc.date.accessioned2023-08-05T07:55:33Z-
dc.date.available2023-08-05T07:55:33Z-
dc.date.issued2023-06-14-
dc.identifier.citationJCO Precision Oncology, 2023-
dc.identifier.issn2473-4284-
dc.identifier.urihttp://hdl.handle.net/10722/329133-
dc.description.abstract<div><p><strong>Background: </strong> Next-generation sequencing comprehensive genomic panels (NGS CGPs) have enabled the delivery of tailor-made therapeutic approaches to improve survival outcomes in patients with cancer. Within the China Greater Bay Area (GBA), territorial differences in clinical practices and health care systems and strengthening collaboration warrant a regional consensus to consolidate the development and integration of precision oncology (PO). Therefore, the Precision Oncology Working Group (POWG) formulated standardized principles for the clinical application of molecular profiling, interpretation of genomic alterations, and alignment of actionable mutations with sequence-directed therapy to deliver clinical services of excellence and evidence-based care to patients with cancer in the China GBA.<br></p><p><strong>Methods: </strong> Thirty experts used a modified Delphi method. The evidence extracted to support the statements was graded according to the GRADE system and reported according to the Revised Standards for Quality Improvement Reporting Excellence guidelines, version 2.0.</p><p><strong>Results: </strong> The POWG reached consensus in six key statements: harmonization of reporting and quality assurance of NGS; molecular tumor board and clinical decision support systems for PO; education and training; research and real-world data collection, patient engagement, regulations, and financial reimbursement of PO treatment strategies; and clinical recommendations and implementation of PO in clinical practice.</p><p><strong>Conclusion: </strong> POWG consensus statements standardize the clinical application of NGS CGPs, streamline the interpretation of clinically significant genomic alterations, and align actionable mutations with sequence-directed therapies. The POWG consensus statements may harmonize the utility and delivery of PO in China's GBA.<br></p></div>-
dc.languageeng-
dc.publisherAmerican Society of Clinical Oncology-
dc.relation.ispartofJCO Precision Oncology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleConsensus Statements on Precision Oncology in the China Greater Bay Area-
dc.typeArticle-
dc.identifier.doi10.1200/po.22.00649-
dc.identifier.eissn2473-4284-
dc.identifier.issnl2473-4284-

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