File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Self-Tandem Bio-Heterojunctions Empower Orthopedic Implants with Amplified Chemo-Photodynamic Anti-Pathogenic Therapy and Boosted Diabetic Osseointegration

TitleSelf-Tandem Bio-Heterojunctions Empower Orthopedic Implants with Amplified Chemo-Photodynamic Anti-Pathogenic Therapy and Boosted Diabetic Osseointegration
Authors
Keywordsheterojunctions
orthopedic implants
osseointegration
polyetheretherketone
self-tandem
Issue Date23-Apr-2023
PublisherWiley
Citation
Advanced Functional Materials, 2023, v. 33, n. 27 How to Cite?
Abstract

Hyperglycemic microenvironment in diabetes mellitus inevitably stalls the normal orchestrated course of bone regeneration and encourages pathogenic multiplication. Photodynamic therapy (PDT) and chemo-dynamic therapy (CDT) are extensively harnessed to combat pathogens, yet deep-seated diabetic bone defect has difficulty in supplying sufficient oxygen (O2) and hydrogen peroxide (H2O2) stocks, resulting in inferior therapeutic efficiency. To address the tough plaguing, the self-tandem bio-heterojunctions (bio-HJs) consisting of molybdenum disulfide (MoS2), graphene oxide (GO), and glucose oxidase (GOx) are constructed on orthopedic polyetheretherketone (PEEK) implants (SP-Mo/G@GOx) for amplified chemo-photodynamic anti-pathogenic therapy and boosted osseointegration in the deep-seated diabetic micromilieu. In this system, GOx exhausts glucose to generate H2O2, which provides an abundant stock for CDT. Besides, the bio-HJs produce hyperthermia upon near-infrared light (NIR) to accelerate the dynamic process, which amplifies the antibacterial potency of PDT by promoting the vast yield of singlet oxygen (1O2) in a self-tandem manner. More importantly, in vivo and in vitro assays demonstrate that the engineered implants exert a captivated bactericidal ability and significantly boost osseointegration in an infectious diabetic bone defect model. As envisaged, this study furnishes a novel tactic to arm orthopedic implants with self-tandem capability for the remedy of infectious diabetic bone defects.


Persistent Identifierhttp://hdl.handle.net/10722/329102
ISSN
2023 Impact Factor: 18.5
2023 SCImago Journal Rankings: 5.496
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShu, Rui-
dc.contributor.authorSun, Jiamin-
dc.contributor.authorLi, Bin-
dc.contributor.authorGao, Xiangyu-
dc.contributor.authorHe, Miaomiao-
dc.contributor.authorChan, Yau Kei-
dc.contributor.authorShi, Jiacheng-
dc.contributor.authorBai, Ding-
dc.contributor.authorYang, Weizhong-
dc.contributor.authorDeng, Yi-
dc.date.accessioned2023-08-05T07:55:18Z-
dc.date.available2023-08-05T07:55:18Z-
dc.date.issued2023-04-23-
dc.identifier.citationAdvanced Functional Materials, 2023, v. 33, n. 27-
dc.identifier.issn1616-301X-
dc.identifier.urihttp://hdl.handle.net/10722/329102-
dc.description.abstract<p>Hyperglycemic microenvironment in diabetes mellitus inevitably stalls the normal orchestrated course of bone regeneration and encourages pathogenic multiplication. Photodynamic therapy (PDT) and chemo-dynamic therapy (CDT) are extensively harnessed to combat pathogens, yet deep-seated diabetic bone defect has difficulty in supplying sufficient oxygen (O<sub>2</sub>) and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) stocks, resulting in inferior therapeutic efficiency. To address the tough plaguing, the self-tandem bio-heterojunctions (bio-HJs) consisting of molybdenum disulfide (MoS<sub>2</sub>), graphene oxide (GO), and glucose oxidase (GOx) are constructed on orthopedic polyetheretherketone (PEEK) implants (SP-Mo/G@GOx) for amplified chemo-photodynamic anti-pathogenic therapy and boosted osseointegration in the deep-seated diabetic micromilieu. In this system, GOx exhausts glucose to generate H<sub>2</sub>O<sub>2</sub>, which provides an abundant stock for CDT. Besides, the bio-HJs produce hyperthermia upon near-infrared light (NIR) to accelerate the dynamic process, which amplifies the antibacterial potency of PDT by promoting the vast yield of singlet oxygen (<sup>1</sup>O<sub>2</sub>) in a self-tandem manner. More importantly, in vivo and in vitro assays demonstrate that the engineered implants exert a captivated bactericidal ability and significantly boost osseointegration in an infectious diabetic bone defect model. As envisaged, this study furnishes a novel tactic to arm orthopedic implants with self-tandem capability for the remedy of infectious diabetic bone defects.</p>-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofAdvanced Functional Materials-
dc.subjectheterojunctions-
dc.subjectorthopedic implants-
dc.subjectosseointegration-
dc.subjectpolyetheretherketone-
dc.subjectself-tandem-
dc.titleSelf-Tandem Bio-Heterojunctions Empower Orthopedic Implants with Amplified Chemo-Photodynamic Anti-Pathogenic Therapy and Boosted Diabetic Osseointegration-
dc.typeArticle-
dc.identifier.doi10.1002/adfm.202214873-
dc.identifier.scopuseid_2-s2.0-85153117508-
dc.identifier.volume33-
dc.identifier.issue27-
dc.identifier.eissn1616-3028-
dc.identifier.isiWOS:000974715100001-
dc.identifier.issnl1616-301X-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats