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Article: Human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection

TitleHuman early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection
Authors
KeywordsEPSC
expanded potential stem cell
human trophoblast
SARS-CoV-2
trophoblast organoid
Issue Date28-Dec-2022
PublisherCell Press
Citation
Cell Reports Medicine, 2022, v. 3, n. 12 How to Cite?
Abstract

Direct in vivo investigation of human placenta trophoblast's susceptibility to SARS-CoV-2 is challenging. Here we report that human trophoblast stem cells (hTSCs) and their derivatives are susceptible to SARSCoV-2 infection, which reveals heterogeneity in hTSC cultures. Early syncytiotrophoblasts (eSTBs) generated from hTSCs have enriched transcriptomic features of peri-implantation trophoblasts, express high levels of angiotensin-converting enzyme 2 (ACE2), and are productively infected by SARS-CoV-2 and its Delta and Omicron variants to produce virions. Antiviral drugs suppress SARS-CoV-2 replication in eSTBs and antagonize the virus-induced blockage of STB maturation. Although less susceptible to SARS-CoV-2 infection, trophoblast organoids originating from hTSCs show detectable viral replication reminiscent of the uncommon placental infection. These findings implicate possible risk of COVID-19 infection in peri-implantation embryos, which may go unnoticed. Stem cell-derived human trophoblasts such as eSTBs can potentially provide unlimited amounts of normal and genome-edited cells and facilitate coronavirus research and antiviral discovery.


Persistent Identifierhttp://hdl.handle.net/10722/329025
ISSN
2023 Impact Factor: 11.7
2023 SCImago Journal Rankings: 4.276
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRuan, DG-
dc.contributor.authorYe, ZW-
dc.contributor.authorYuan, SF-
dc.contributor.authorLi, ZX-
dc.contributor.authorZhang, WY-
dc.contributor.authorOng, CP-
dc.contributor.authorTang, KM-
dc.contributor.authorTam, TTKK-
dc.contributor.authorGuo, JL-
dc.contributor.authorXuan, YY-
dc.contributor.authorHuang, YY-
dc.contributor.authorZhang, QQ-
dc.contributor.authorLee, CL-
dc.contributor.authorLu, LM-
dc.contributor.authorChiu, PCN-
dc.contributor.authorYeung, WSB-
dc.contributor.authorLiu, F-
dc.contributor.authorJin, DY-
dc.contributor.authorLiu, PT-
dc.date.accessioned2023-08-05T07:54:43Z-
dc.date.available2023-08-05T07:54:43Z-
dc.date.issued2022-12-28-
dc.identifier.citationCell Reports Medicine, 2022, v. 3, n. 12-
dc.identifier.issn2666-3791-
dc.identifier.urihttp://hdl.handle.net/10722/329025-
dc.description.abstract<p> Direct in vivo investigation of human placenta trophoblast's susceptibility to SARS-CoV-2 is challenging. Here we report that human trophoblast stem cells (hTSCs) and their derivatives are susceptible to SARSCoV-2 infection, which reveals heterogeneity in hTSC cultures. Early syncytiotrophoblasts (eSTBs) generated from hTSCs have enriched transcriptomic features of peri-implantation trophoblasts, express high levels of angiotensin-converting enzyme 2 (ACE2), and are productively infected by SARS-CoV-2 and its Delta and Omicron variants to produce virions. Antiviral drugs suppress SARS-CoV-2 replication in eSTBs and antagonize the virus-induced blockage of STB maturation. Although less susceptible to SARS-CoV-2 infection, trophoblast organoids originating from hTSCs show detectable viral replication reminiscent of the uncommon placental infection. These findings implicate possible risk of COVID-19 infection in peri-implantation embryos, which may go unnoticed. Stem cell-derived human trophoblasts such as eSTBs can potentially provide unlimited amounts of normal and genome-edited cells and facilitate coronavirus research and antiviral discovery. <br></p>-
dc.languageeng-
dc.publisherCell Press-
dc.relation.ispartofCell Reports Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectEPSC-
dc.subjectexpanded potential stem cell-
dc.subjecthuman trophoblast-
dc.subjectSARS-CoV-2-
dc.subjecttrophoblast organoid-
dc.titleHuman early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.xcrm.2022.100849-
dc.identifier.scopuseid_2-s2.0-85144360239-
dc.identifier.volume3-
dc.identifier.issue12-
dc.identifier.eissn2666-3791-
dc.identifier.isiWOS:000912394300001-
dc.identifier.issnl2666-3791-

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