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Article: Anti-inflammatory effect of gallic acid on HaCaT keratinocytes through the inhibition of MAPK-, NF-kB-, and Akt-dependent signaling pathways
Title | Anti-inflammatory effect of gallic acid on HaCaT keratinocytes through the inhibition of MAPK-, NF-kB-, and Akt-dependent signaling pathways |
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Authors | |
Issue Date | 15-Jan-2023 |
Publisher | Bangladesh Pharmacological Society |
Citation | Bangladesh Journal of Pharmacology, 2023, v. 18, n. 1, p. 18-32 How to Cite? |
Abstract | The objectives of the present study were to evaluate the antioxidant and anti-inflammatory effects of gallic acid, a naturally occurring triphenolic compound, on HaCaT keratinocytes and study its mechanisms of action. The results showed that gallic acid at concentrations lower than 30 µM was non-toxic to HaCaT cells, reduced the intracellular level of reactive oxygen species, and suppressed the release of chemokines interleukin-8 and monocyte chemoattractant protein-1 in tumor necrosis factor-α- and interferon-γ-stimulated HaCaT keratinocytes. In addition, gallic acid reduced the total protein expression of NF-κB and inhibited the phosphorylation of ERK1/2, p38 MAPK, and Akt in stimulated HaCaT keratinocytes. In conclusion, our study revealed that gallic acid exhibited antioxidant and anti-inflammatory effects on keratinocytes, probably through the inhibition of MAPK-, NF-κB-, and Akt-dependent signaling pathways. |
Persistent Identifier | http://hdl.handle.net/10722/329001 |
ISSN | 2023 Impact Factor: 0.9 2023 SCImago Journal Rankings: 0.214 |
DC Field | Value | Language |
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dc.contributor.author | Shiu, Ho Ting | - |
dc.contributor.author | Zheng, Chengwen | - |
dc.contributor.author | Rangsinth, Panthakarn | - |
dc.contributor.author | Wang, Wen | - |
dc.contributor.author | Li, Jingjing | - |
dc.contributor.author | Li, Renkai | - |
dc.contributor.author | Leung, George Pak Heng | - |
dc.date.accessioned | 2023-08-05T07:54:31Z | - |
dc.date.available | 2023-08-05T07:54:31Z | - |
dc.date.issued | 2023-01-15 | - |
dc.identifier.citation | Bangladesh Journal of Pharmacology, 2023, v. 18, n. 1, p. 18-32 | - |
dc.identifier.issn | 1991-007X | - |
dc.identifier.uri | http://hdl.handle.net/10722/329001 | - |
dc.description.abstract | <p>The objectives of the present study were to evaluate the antioxidant and anti-inflammatory effects of gallic acid, a naturally occurring triphenolic compound, on HaCaT keratinocytes and study its mechanisms of action. The results showed that gallic acid at concentrations lower than 30 µM was non-toxic to HaCaT cells, reduced the intracellular level of reactive oxygen species, and suppressed the release of chemokines interleukin-8 and monocyte chemoattractant protein-1 in tumor necrosis factor-α- and interferon-γ-stimulated HaCaT keratinocytes. In addition, gallic acid reduced the total protein expression of NF-κB and inhibited the phosphorylation of ERK1/2, p38 MAPK, and Akt in stimulated HaCaT keratinocytes. In conclusion, our study revealed that gallic acid exhibited antioxidant and anti-inflammatory effects on keratinocytes, probably through the inhibition of MAPK-, NF-κB-, and Akt-dependent signaling pathways.</p> | - |
dc.language | eng | - |
dc.publisher | Bangladesh Pharmacological Society | - |
dc.relation.ispartof | Bangladesh Journal of Pharmacology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Anti-inflammatory effect of gallic acid on HaCaT keratinocytes through the inhibition of MAPK-, NF-kB-, and Akt-dependent signaling pathways | - |
dc.type | Article | - |
dc.identifier.doi | 10.3329/bjp.v18i1.63052 | - |
dc.identifier.scopus | eid_2-s2.0-85146504605 | - |
dc.identifier.volume | 18 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 18 | - |
dc.identifier.epage | 32 | - |
dc.identifier.eissn | 1991-0088 | - |
dc.identifier.issnl | 1991-007X | - |