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- Publisher Website: 10.1111/bju.16044
- Scopus: eid_2-s2.0-85161463298
- PMID: 37169730
- WOS: WOS:001000282100001
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Article: Outcomes of penile sarcomatoid squamous cell carcinoma from a single tertiary referral centre: a matched cohort study
Title | Outcomes of penile sarcomatoid squamous cell carcinoma from a single tertiary referral centre: a matched cohort study |
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Authors | |
Keywords | oncological outcomes penile cancer sarcomatoid squamous cell carcinoma urogenital cancer |
Issue Date | 2023 |
Citation | BJU International, 2023 How to Cite? |
Abstract | Objective: To report the oncological survival outcomes of men with penile sarcomatoid squamous cell carcinoma (sSCC). Patients and Methods: A retrospective analysis of men with penile sSCC diagnosed between January 2010 and January 2020 in a single centre was conducted. Disease-specific (DSS), recurrence-free (RFS) and metastasis-free (MFS) survival were evaluated. Outcomes were compared with a non-sarcomatoid penile SCC cohort matched to age, type of surgery and tumour stage. Kaplan–Meier plots were used to estimate survival outcomes. Results: In all, 1286 men were diagnosed with penile SCC during the study period and of these 38 (3%) men had sSCC. The median (interquartile range) age and follow-up was 70 (57–81) years and 16 (7–44) months, respectively. Operations performed included: circumcision, one (2.6%); wide local excision, four (10.5%); glansectomy, 11 (29%); partial penectomy, 10 (26%); subtotal/total penectomy, 12 (32%). The Kaplan–Meier estimated 12-, 24- and 36-month DSS was 62% (vs non-sarcomatoid, 67%), 43% (vs non-sarcomatoid, 67%) and 36% (vs non-sarcomatoid, 67%), respectively (P = 0.03). The Kaplan–Meier estimated 12- and 24-month RFS was 47% (vs non-sarcomatoid, 60%) and 28% (vs non-sarcomatoid, 55%), respectively (P = 0.01). The MFS was 52% (vs non-sarcomatoid, 62%) at 12 months and 37% (vs non-sarcomatoid, 57%) at 24 months (P = 0.04). Conclusions: Sarcomatoid differentiation was associated with a lower DSS, RFS and MFS. Due to the rarity of its incidence and aggressiveness, expert histological review and multidisciplinary management is required in a specialist penile cancer centre. |
Persistent Identifier | http://hdl.handle.net/10722/328862 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.337 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Pang, Karl H. | - |
dc.contributor.author | Girling, Benedict | - |
dc.contributor.author | Osinibi, Elizabeth | - |
dc.contributor.author | Sawhney, Paramvir | - |
dc.contributor.author | Haider, Aiman | - |
dc.contributor.author | Freeman, Alex | - |
dc.contributor.author | Hadway, Paul | - |
dc.contributor.author | Nigam, Raj | - |
dc.contributor.author | Rees, Rowland | - |
dc.contributor.author | Mitra, Anita | - |
dc.contributor.author | Muneer, Asif | - |
dc.contributor.author | Alifrangis, Constantine | - |
dc.contributor.author | Alnajjar, Hussain M. | - |
dc.date.accessioned | 2023-07-22T06:24:44Z | - |
dc.date.available | 2023-07-22T06:24:44Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | BJU International, 2023 | - |
dc.identifier.issn | 1464-4096 | - |
dc.identifier.uri | http://hdl.handle.net/10722/328862 | - |
dc.description.abstract | Objective: To report the oncological survival outcomes of men with penile sarcomatoid squamous cell carcinoma (sSCC). Patients and Methods: A retrospective analysis of men with penile sSCC diagnosed between January 2010 and January 2020 in a single centre was conducted. Disease-specific (DSS), recurrence-free (RFS) and metastasis-free (MFS) survival were evaluated. Outcomes were compared with a non-sarcomatoid penile SCC cohort matched to age, type of surgery and tumour stage. Kaplan–Meier plots were used to estimate survival outcomes. Results: In all, 1286 men were diagnosed with penile SCC during the study period and of these 38 (3%) men had sSCC. The median (interquartile range) age and follow-up was 70 (57–81) years and 16 (7–44) months, respectively. Operations performed included: circumcision, one (2.6%); wide local excision, four (10.5%); glansectomy, 11 (29%); partial penectomy, 10 (26%); subtotal/total penectomy, 12 (32%). The Kaplan–Meier estimated 12-, 24- and 36-month DSS was 62% (vs non-sarcomatoid, 67%), 43% (vs non-sarcomatoid, 67%) and 36% (vs non-sarcomatoid, 67%), respectively (P = 0.03). The Kaplan–Meier estimated 12- and 24-month RFS was 47% (vs non-sarcomatoid, 60%) and 28% (vs non-sarcomatoid, 55%), respectively (P = 0.01). The MFS was 52% (vs non-sarcomatoid, 62%) at 12 months and 37% (vs non-sarcomatoid, 57%) at 24 months (P = 0.04). Conclusions: Sarcomatoid differentiation was associated with a lower DSS, RFS and MFS. Due to the rarity of its incidence and aggressiveness, expert histological review and multidisciplinary management is required in a specialist penile cancer centre. | - |
dc.language | eng | - |
dc.relation.ispartof | BJU International | - |
dc.subject | oncological outcomes | - |
dc.subject | penile cancer | - |
dc.subject | sarcomatoid | - |
dc.subject | squamous cell carcinoma | - |
dc.subject | urogenital cancer | - |
dc.title | Outcomes of penile sarcomatoid squamous cell carcinoma from a single tertiary referral centre: a matched cohort study | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/bju.16044 | - |
dc.identifier.pmid | 37169730 | - |
dc.identifier.scopus | eid_2-s2.0-85161463298 | - |
dc.identifier.eissn | 1464-410X | - |
dc.identifier.isi | WOS:001000282100001 | - |