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Article: A Solitary Osteolytic Lesion With Pathological Fracture In The Cervical Spine - A Case Report

TitleA Solitary Osteolytic Lesion With Pathological Fracture In The Cervical Spine - A Case Report
Authors
Issue Date30-May-2023
PublisherBioMed Central
Citation
BMC Musculoskeletal Disorders, 2023, v. 24, n. 1 How to Cite?
Abstract

Background

Langerhans cell histiocytosis (LCH) is a rare disorder. The treatment options vary depending on how many organs are involved and how extensive the disease is. In this report, a case of LCH with isolated 6th cervical vertebra (C6) collapse was presented. This case was treated with anterior corpectomy and instrumented fusion, followed by local radiotherapy (RT), with a good clinical outcome up to postoperative six months.

Case presentation

This was a 47-year-old female patient with a complaint of neck pain and bilateral shoulder pain for two months before consultation. She was initially treated with analgesics, but the pain was persistent. Further radiological evaluations revealed an osteolytic lesion within the C6 vertebral body with a pathological fracture. Magnetic resonance imaging (MRI) with contrast of the cervical spine revealed diffused hypointense signal changes on the T1-weighted images and hyperintense signal changes on the T2-weighted images in the C6 vertebral body, with significant contrast-enhanced infiltration signals. Furthermore, in positron emission tomography-computed tomography (PET-CT), focal hypermetabolism and abnormal uptake signals were seen only in the C6 vertebral body. The patient underwent an anterior cervical corpectomy with instrumented fusion. The histopathological results confirmed the diagnosis of LCH. The patient reported significant pain relief on postoperative day one. Moreover, she was treated by local RT at postoperative one month. Good clinical outcomes were achieved in the form of no pain and recovery in neck mobility up to postoperative six months. No evidence of recurrence was observed at the final follow-up.

Conclusions

This case report describes a treatment option for a solitary C6 collapse with LCH managed by anterior corpectomy and instrumented fusion, followed by local RT, with a good clinical outcome at postoperative six months. More studies are needed to elucidate whether such a treatment strategy is superior to surgery or RT alone.


Persistent Identifierhttp://hdl.handle.net/10722/328519
ISSN
2023 Impact Factor: 2.2
2023 SCImago Journal Rankings: 0.714
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKuang, GM-
dc.contributor.authorLoo, NN-
dc.contributor.authorGao, Q-
dc.contributor.authorLi, J-
dc.contributor.authorLuo, L-
dc.contributor.authorChen, S-
dc.contributor.authorCheung, JPY-
dc.contributor.authorCheung, KMC-
dc.date.accessioned2023-06-28T04:45:41Z-
dc.date.available2023-06-28T04:45:41Z-
dc.date.issued2023-05-30-
dc.identifier.citationBMC Musculoskeletal Disorders, 2023, v. 24, n. 1-
dc.identifier.issn1471-2474-
dc.identifier.urihttp://hdl.handle.net/10722/328519-
dc.description.abstract<h3>Background</h3><p>Langerhans cell histiocytosis (LCH) is a rare disorder. The treatment options vary depending on how many organs are involved and how extensive the disease is. In this report, a case of LCH with isolated 6th cervical vertebra (C6) collapse was presented. This case was treated with anterior corpectomy and instrumented fusion, followed by local radiotherapy (RT), with a good clinical outcome up to postoperative six months.</p><h3>Case presentation</h3><p>This was a 47-year-old female patient with a complaint of neck pain and bilateral shoulder pain for two months before consultation. She was initially treated with analgesics, but the pain was persistent. Further radiological evaluations revealed an osteolytic lesion within the C6 vertebral body with a pathological fracture. Magnetic resonance imaging (MRI) with contrast of the cervical spine revealed diffused hypointense signal changes on the T1-weighted images and hyperintense signal changes on the T2-weighted images in the C6 vertebral body, with significant contrast-enhanced infiltration signals. Furthermore, in positron emission tomography-computed tomography (PET-CT), focal hypermetabolism and abnormal uptake signals were seen only in the C6 vertebral body. The patient underwent an anterior cervical corpectomy with instrumented fusion. The histopathological results confirmed the diagnosis of LCH. The patient reported significant pain relief on postoperative day one. Moreover, she was treated by local RT at postoperative one month. Good clinical outcomes were achieved in the form of no pain and recovery in neck mobility up to postoperative six months. No evidence of recurrence was observed at the final follow-up.</p><h3>Conclusions</h3><p>This case report describes a treatment option for a solitary C6 collapse with LCH managed by anterior corpectomy and instrumented fusion, followed by local RT, with a good clinical outcome at postoperative six months. More studies are needed to elucidate whether such a treatment strategy is superior to surgery or RT alone.</p>-
dc.languageeng-
dc.publisherBioMed Central-
dc.relation.ispartofBMC Musculoskeletal Disorders-
dc.titleA Solitary Osteolytic Lesion With Pathological Fracture In The Cervical Spine - A Case Report-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12891-023-06543-2-
dc.identifier.volume24-
dc.identifier.issue1-
dc.identifier.eissn1471-2474-
dc.identifier.isiWOS:000999916800006-
dc.identifier.issnl1471-2474-

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