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Article: Peptide Designs for Use in Caries Management: A Systematic Review

TitlePeptide Designs for Use in Caries Management: A Systematic Review
Authors
Issue Date20-Feb-2023
PublisherMDPI
Citation
International Journal of Molecular Sciences, 2023, v. 24, n. 4 How to Cite?
Abstract

The objective of this study was to review the design methods that have been used to create peptides for use in caries management. Two independent researchers systematically reviewed many in vitro studies in which peptides were designed for use in caries management. They assessed the risk of bias in the included studies. This review identified 3592 publications, of which 62 were selected. Forty-seven studies reported 57 antimicrobial peptides. Among them, 31 studies (66%, 31/47) used the template-based design method; 9 studies (19%, 9/47) used the conjugation method; and 7 studies (15%, 7/47) used other methods, such as the synthetic combinatorial technology method, the de novo design method and cyclisation. Ten studies reported mineralising peptides. Seven of these (70%, 7/10) used the template-based design method, two (20%, 2/10) used the de novo design method, and one study (10%, 1/10) used the conjugation method. In addition, five studies developed their own peptides with antimicrobial and mineralising properties. These studies used the conjugation method. Our assessment for the risk of bias in the 62 reviewed studies showed that 44 publications (71%, 44/62) had a medium risk and that 3 publications had a low risk (5%, 3/62). The two most common methods for developing peptides for use in caries management that were used in these studies were the template-based design method and the conjugation method.


Persistent Identifierhttp://hdl.handle.net/10722/328439
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.179

 

DC FieldValueLanguage
dc.contributor.authorZhang, OL-
dc.contributor.authorNiu, JY-
dc.contributor.authorYu, OY-
dc.contributor.authorMei, ML-
dc.contributor.authorJakubovics, NS-
dc.contributor.authorChu, CH-
dc.date.accessioned2023-06-28T04:44:56Z-
dc.date.available2023-06-28T04:44:56Z-
dc.date.issued2023-02-20-
dc.identifier.citationInternational Journal of Molecular Sciences, 2023, v. 24, n. 4-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/328439-
dc.description.abstract<p>The objective of this study was to review the design methods that have been used to create peptides for use in caries management. Two independent researchers systematically reviewed many in vitro studies in which peptides were designed for use in caries management. They assessed the risk of bias in the included studies. This review identified 3592 publications, of which 62 were selected. Forty-seven studies reported 57 antimicrobial peptides. Among them, 31 studies (66%, 31/47) used the template-based design method; 9 studies (19%, 9/47) used the conjugation method; and 7 studies (15%, 7/47) used other methods, such as the synthetic combinatorial technology method, the de novo design method and cyclisation. Ten studies reported mineralising peptides. Seven of these (70%, 7/10) used the template-based design method, two (20%, 2/10) used the de novo design method, and one study (10%, 1/10) used the conjugation method. In addition, five studies developed their own peptides with antimicrobial and mineralising properties. These studies used the conjugation method. Our assessment for the risk of bias in the 62 reviewed studies showed that 44 publications (71%, 44/62) had a medium risk and that 3 publications had a low risk (5%, 3/62). The two most common methods for developing peptides for use in caries management that were used in these studies were the template-based design method and the conjugation method.<br></p>-
dc.languageeng-
dc.publisherMDPI-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.titlePeptide Designs for Use in Caries Management: A Systematic Review-
dc.typeArticle-
dc.identifier.doi10.3390/ijms24044247-
dc.identifier.volume24-
dc.identifier.issue4-
dc.identifier.eissn1422-0067-
dc.identifier.issnl1422-0067-

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