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Article: Weak bonding strategies for achieving regio- and site-selective transformations

TitleWeak bonding strategies for achieving regio- and site-selective transformations
Authors
Keywordsdynamic covalent bonds
host-guest chemistry
nanoconfinement
noncovalent bonding interactions
pre-organization
regioselectivity
SDG12: Responsible consumption and production
SDG3: Good health and well-being
supramolecular catalysis
Issue Date2022
Citation
Chem, 2022, v. 8, n. 2, p. 414-438 How to Cite?
AbstractThe ability to identify and transform selectively similar constitutional fragments in molecules in a predetermined direction over all other possible directions remains a fundamental challenge in relation to the growth and reach of synthetic chemistry. A rapidly emerging approach toward this goal is to leverage weak bonding interactions, including both noncovalent and dynamic covalent bonds to control regio- and site selectivities. Drawing inspiration from the reactions catalyzed by enzymes, chemists have developed a wide variety of weak bonding strategies to facilitate regio- and site-selective transformations without the need to introduce additional handles onto molecular frameworks. Here, by classifying these weak bonding protocols into four categories, namely, bond-destabilizing, masking, pre-organizing, and templating strategies, we summarize the advances that have been made during the past two decades, highlighting their relative simplicity in promoting regio- and site-selective reactions that would otherwise be difficult to perform on molecules.
Persistent Identifierhttp://hdl.handle.net/10722/327737
ISSN
2023 SCImago Journal Rankings: 6.556
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJiao, Yang-
dc.contributor.authorChen, Xiao Yang-
dc.contributor.authorStoddart, J. Fraser-
dc.date.accessioned2023-04-24T05:09:37Z-
dc.date.available2023-04-24T05:09:37Z-
dc.date.issued2022-
dc.identifier.citationChem, 2022, v. 8, n. 2, p. 414-438-
dc.identifier.issn2451-9308-
dc.identifier.urihttp://hdl.handle.net/10722/327737-
dc.description.abstractThe ability to identify and transform selectively similar constitutional fragments in molecules in a predetermined direction over all other possible directions remains a fundamental challenge in relation to the growth and reach of synthetic chemistry. A rapidly emerging approach toward this goal is to leverage weak bonding interactions, including both noncovalent and dynamic covalent bonds to control regio- and site selectivities. Drawing inspiration from the reactions catalyzed by enzymes, chemists have developed a wide variety of weak bonding strategies to facilitate regio- and site-selective transformations without the need to introduce additional handles onto molecular frameworks. Here, by classifying these weak bonding protocols into four categories, namely, bond-destabilizing, masking, pre-organizing, and templating strategies, we summarize the advances that have been made during the past two decades, highlighting their relative simplicity in promoting regio- and site-selective reactions that would otherwise be difficult to perform on molecules.-
dc.languageeng-
dc.relation.ispartofChem-
dc.subjectdynamic covalent bonds-
dc.subjecthost-guest chemistry-
dc.subjectnanoconfinement-
dc.subjectnoncovalent bonding interactions-
dc.subjectpre-organization-
dc.subjectregioselectivity-
dc.subjectSDG12: Responsible consumption and production-
dc.subjectSDG3: Good health and well-being-
dc.subjectsupramolecular catalysis-
dc.titleWeak bonding strategies for achieving regio- and site-selective transformations-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.chempr.2021.12.012-
dc.identifier.scopuseid_2-s2.0-85124192584-
dc.identifier.volume8-
dc.identifier.issue2-
dc.identifier.spage414-
dc.identifier.epage438-
dc.identifier.eissn2451-9294-
dc.identifier.isiWOS:000754886700010-

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