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Article: Synthesis of Fluorenones from Benzaldehydes and Aryl Iodides: Dual C-H Functionalizations Using a Transient Directing Group

TitleSynthesis of Fluorenones from Benzaldehydes and Aryl Iodides: Dual C-H Functionalizations Using a Transient Directing Group
Authors
Chen, Xiao YangOzturk, SeymaSorensen, Erik J.
Issue Date2017
Citation
Organic Letters, 2017, v. 19, n. 5, p. 1140-1143 How to Cite?
DOI: http://dx.doi.org/10.1021/acs.orglett.7b00161
AbstractThe first synthesis of substituted fluorenones directly from benzaldehydes and aryl iodides via a Pd(II)-catalyzed C(sp2)-H functionalization cascade is reported. Featuring anthranilic acid as an inexpensive transient directing group, the process is compatible with a variety of benzaldehydes and aryl iodides. A three-step synthesis of the antiviral drug Tilorone was completed in an excellent overall yield (40%), demonstrating the utility of this method.
Persistent Identifierhttp://hdl.handle.net/10722/327694
ISSN
1523-7060
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.245
ISI Accession Number ID
WOS:000395726100044

 

DC FieldValueLanguage
dc.contributor.authorChen, Xiao Yang-
dc.contributor.authorOzturk, Seyma-
dc.contributor.authorSorensen, Erik J.-
dc.date.accessioned2023-04-24T05:09:16Z-
dc.date.available2023-04-24T05:09:16Z-
dc.date.issued2017-
dc.identifier.citationOrganic Letters, 2017, v. 19, n. 5, p. 1140-1143-
dc.identifier.issn1523-7060-
dc.identifier.urihttp://hdl.handle.net/10722/327694-
dc.description.abstractThe first synthesis of substituted fluorenones directly from benzaldehydes and aryl iodides via a Pd(II)-catalyzed C(sp2)-H functionalization cascade is reported. Featuring anthranilic acid as an inexpensive transient directing group, the process is compatible with a variety of benzaldehydes and aryl iodides. A three-step synthesis of the antiviral drug Tilorone was completed in an excellent overall yield (40%), demonstrating the utility of this method.-
dc.languageeng-
dc.relation.ispartofOrganic Letters-
dc.titleSynthesis of Fluorenones from Benzaldehydes and Aryl Iodides: Dual C-H Functionalizations Using a Transient Directing Group-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.orglett.7b00161-
dc.identifier.pmid28225629-
dc.identifier.scopuseid_2-s2.0-85014520104-
dc.identifier.volume19-
dc.identifier.issue5-
dc.identifier.spage1140-
dc.identifier.epage1143-
dc.identifier.eissn1523-7052-
dc.identifier.isiWOS:000395726100044-

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