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Article: Economic costs and health utility values associated with extremely preterm birth: Evidence from the EPICure2 cohort study

TitleEconomic costs and health utility values associated with extremely preterm birth: Evidence from the EPICure2 cohort study
Authors
Keywordscosts
economic
extremely preterm
health utilities
Issue Date2022
Citation
Paediatric and Perinatal Epidemiology, 2022, v. 36, n. 5, p. 696-705 How to Cite?
AbstractBackground: Preterm birth is associated with adverse health and developmental sequelae that impose a burden on finite resources and significant challenges for individuals, families and societies. Objectives: To estimate economic outcomes at age 11 associated with extremely preterm birth using evidence from a whole population study (EPICure2 study). Methods: The study population comprised a sample of children born at ≤26 completed weeks of gestation during 2006 in England (n = 200) and a comparison group of classmates born at term (n = 143). Societal costs were estimated using parent and teacher reports of service utilisation, and valuations of work losses and additional care costs to families. Utility scores for the Health Utilities Index Mark 2 (HUI2) and Mark 3 (HUI3) were generated using UK and Canadian value sets. Generalised linear regression was used to estimate the impact of extremely preterm birth on societal costs and utility scores. Results: Unadjusted mean societal costs that excluded provision of special educational support in mainstream schools during the 11th year after birth were £6536 for the extremely preterm group and £3275 for their classmates, generating a difference of £3262 (95% confidence interval [CI] £1912, £5543). The mean adjusted cost difference was £2916 (95% CI £1609, £4224), including special educational needs provision in mainstream schools increased the adjusted cost difference to £4772 (95% CI £3166, £6378). Compared with birth at term, extremely preterm birth generated mean-adjusted utility decrements ranging from 0.13 (95% CI 0.09, 0.18) based on the UK HUI2 statistical inference tariff to 0.28 (95% CI 0.18, 0.37) based on the Canadian HUI3 tariff. Conclusions: The adverse economic impact of extremely preterm birth persists into late childhood. Further longitudinal studies conducted from multiple perspectives are needed to understand the magnitude, trajectory and underpinning mechanisms of economic outcomes following extremely preterm birth.
Persistent Identifierhttp://hdl.handle.net/10722/325695
ISSN
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 1.124
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAchana, Felix-
dc.contributor.authorJohnson, Samantha-
dc.contributor.authorNi, Yanyan-
dc.contributor.authorMarlow, Neil-
dc.contributor.authorWolke, Dieter-
dc.contributor.authorKhan, Kamran-
dc.contributor.authorPetrou, Stavros-
dc.date.accessioned2023-02-27T07:35:30Z-
dc.date.available2023-02-27T07:35:30Z-
dc.date.issued2022-
dc.identifier.citationPaediatric and Perinatal Epidemiology, 2022, v. 36, n. 5, p. 696-705-
dc.identifier.issn0269-5022-
dc.identifier.urihttp://hdl.handle.net/10722/325695-
dc.description.abstractBackground: Preterm birth is associated with adverse health and developmental sequelae that impose a burden on finite resources and significant challenges for individuals, families and societies. Objectives: To estimate economic outcomes at age 11 associated with extremely preterm birth using evidence from a whole population study (EPICure2 study). Methods: The study population comprised a sample of children born at ≤26 completed weeks of gestation during 2006 in England (n = 200) and a comparison group of classmates born at term (n = 143). Societal costs were estimated using parent and teacher reports of service utilisation, and valuations of work losses and additional care costs to families. Utility scores for the Health Utilities Index Mark 2 (HUI2) and Mark 3 (HUI3) were generated using UK and Canadian value sets. Generalised linear regression was used to estimate the impact of extremely preterm birth on societal costs and utility scores. Results: Unadjusted mean societal costs that excluded provision of special educational support in mainstream schools during the 11th year after birth were £6536 for the extremely preterm group and £3275 for their classmates, generating a difference of £3262 (95% confidence interval [CI] £1912, £5543). The mean adjusted cost difference was £2916 (95% CI £1609, £4224), including special educational needs provision in mainstream schools increased the adjusted cost difference to £4772 (95% CI £3166, £6378). Compared with birth at term, extremely preterm birth generated mean-adjusted utility decrements ranging from 0.13 (95% CI 0.09, 0.18) based on the UK HUI2 statistical inference tariff to 0.28 (95% CI 0.18, 0.37) based on the Canadian HUI3 tariff. Conclusions: The adverse economic impact of extremely preterm birth persists into late childhood. Further longitudinal studies conducted from multiple perspectives are needed to understand the magnitude, trajectory and underpinning mechanisms of economic outcomes following extremely preterm birth.-
dc.languageeng-
dc.relation.ispartofPaediatric and Perinatal Epidemiology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcosts-
dc.subjecteconomic-
dc.subjectextremely preterm-
dc.subjecthealth utilities-
dc.titleEconomic costs and health utility values associated with extremely preterm birth: Evidence from the EPICure2 cohort study-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1111/ppe.12906-
dc.identifier.pmid35830294-
dc.identifier.pmcidPMC9543967-
dc.identifier.scopuseid_2-s2.0-85133932301-
dc.identifier.volume36-
dc.identifier.issue5-
dc.identifier.spage696-
dc.identifier.epage705-
dc.identifier.eissn1365-3016-
dc.identifier.isiWOS:000824605700001-

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