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Article: Screening for intracranial aneurysms? Prevalence of unruptured intracranial aneurysms in Hong Kong Chinese

TitleScreening for intracranial aneurysms? Prevalence of unruptured intracranial aneurysms in Hong Kong Chinese
Authors
KeywordsChinese
First-degree relative
Hong Kong
Prevalence
Screening
Subarachnoid hemorrhage
Unruptured intracranial aneurysm
Vascular disorders
Issue Date2016
Citation
Journal of Neurosurgery, 2016, v. 124, n. 5, p. 1245-1249 How to Cite?
AbstractObjective The objective of this study was to generate data on the local prevalence of unruptured intracranial aneurysms (UIAs) in asymptomatic Hong Kong Chinese individuals. First-degree relatives of patients with aneurysmal subarachnoid hemorrhage (aSAH) were recruited as surrogates of the general population and to explore the potential role of screening in this locality. Methods The authors identified first-degree relatives of consecutive patients with subarachnoid hemorrhage from a ruptured aneurysm who were admitted to a university hospital in Hong Kong from June 2008 to December 2010. Magnetic resonance angiography (MRA) was the imaging modality used to screen the cerebral vasculature of these asymptomatic individuals. If MRA showed abnormal findings, CT angiography was performed to confirm the MRA findings. Results In total, 7 UIAs were identified from the 305 MR angiograms obtained. The prevalence of UIAs in first-degree relatives of patients with aSAH in the Hong Kong Chinese population was 2.30% (95% CI 1.02%-4.76%). This percentage was lower than the prevalence rate of 3.2% from a meta-analysis of the literature. The sizes of the UIAs detected ranged from 1.4 mm to 7.5 mm; 85.7% of the UIAs detected in this study were < 5 mm, in contrast to 66% noted in the literature. One of the UIAs identified underwent endovascular stent placement with a flow diverter. None of the UIAs identified ruptured or became symptomatic during a median follow-up period of 3.5 years. ConclusionS?The prevalence of UIAs in first-degree relatives of patients with aSAH in the Hong Kong Chinese population was lower than that in Caucasians. At the same time, most of the UIAs detected in this study were small (85.7% were < 5 mm, vs 66% in a meta-analysis). With a similar incidence of aSAH in Hong Kong (7.5 per 100,000 person-years) as compared with data cited in the literature, the hypothesis that UIA rupture risk size threshold is different in Chinese patients should be further investigated.
Persistent Identifierhttp://hdl.handle.net/10722/325687
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 1.173
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, David Y.C.-
dc.contributor.authorAbrigo, Jill M.-
dc.contributor.authorCheung, Tom C.Y.-
dc.contributor.authorSiu, Deyond Y.W.-
dc.contributor.authorPoon, Wai S.-
dc.contributor.authorAhuja, Anil T.-
dc.contributor.authorWong, George K.C.-
dc.date.accessioned2023-02-27T07:35:26Z-
dc.date.available2023-02-27T07:35:26Z-
dc.date.issued2016-
dc.identifier.citationJournal of Neurosurgery, 2016, v. 124, n. 5, p. 1245-1249-
dc.identifier.issn0022-3085-
dc.identifier.urihttp://hdl.handle.net/10722/325687-
dc.description.abstractObjective The objective of this study was to generate data on the local prevalence of unruptured intracranial aneurysms (UIAs) in asymptomatic Hong Kong Chinese individuals. First-degree relatives of patients with aneurysmal subarachnoid hemorrhage (aSAH) were recruited as surrogates of the general population and to explore the potential role of screening in this locality. Methods The authors identified first-degree relatives of consecutive patients with subarachnoid hemorrhage from a ruptured aneurysm who were admitted to a university hospital in Hong Kong from June 2008 to December 2010. Magnetic resonance angiography (MRA) was the imaging modality used to screen the cerebral vasculature of these asymptomatic individuals. If MRA showed abnormal findings, CT angiography was performed to confirm the MRA findings. Results In total, 7 UIAs were identified from the 305 MR angiograms obtained. The prevalence of UIAs in first-degree relatives of patients with aSAH in the Hong Kong Chinese population was 2.30% (95% CI 1.02%-4.76%). This percentage was lower than the prevalence rate of 3.2% from a meta-analysis of the literature. The sizes of the UIAs detected ranged from 1.4 mm to 7.5 mm; 85.7% of the UIAs detected in this study were < 5 mm, in contrast to 66% noted in the literature. One of the UIAs identified underwent endovascular stent placement with a flow diverter. None of the UIAs identified ruptured or became symptomatic during a median follow-up period of 3.5 years. ConclusionS?The prevalence of UIAs in first-degree relatives of patients with aSAH in the Hong Kong Chinese population was lower than that in Caucasians. At the same time, most of the UIAs detected in this study were small (85.7% were < 5 mm, vs 66% in a meta-analysis). With a similar incidence of aSAH in Hong Kong (7.5 per 100,000 person-years) as compared with data cited in the literature, the hypothesis that UIA rupture risk size threshold is different in Chinese patients should be further investigated.-
dc.languageeng-
dc.relation.ispartofJournal of Neurosurgery-
dc.subjectChinese-
dc.subjectFirst-degree relative-
dc.subjectHong Kong-
dc.subjectPrevalence-
dc.subjectScreening-
dc.subjectSubarachnoid hemorrhage-
dc.subjectUnruptured intracranial aneurysm-
dc.subjectVascular disorders-
dc.titleScreening for intracranial aneurysms? Prevalence of unruptured intracranial aneurysms in Hong Kong Chinese-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3171/2015.4.JNS142938-
dc.identifier.pmid26473778-
dc.identifier.scopuseid_2-s2.0-84975109047-
dc.identifier.volume124-
dc.identifier.issue5-
dc.identifier.spage1245-
dc.identifier.epage1249-
dc.identifier.eissn1933-0693-
dc.identifier.isiWOS:000374723000006-

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