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Article: Failure of human rhombic lip differentiation underlies medulloblastoma formation

TitleFailure of human rhombic lip differentiation underlies medulloblastoma formation
Authors
Hendrikse, Liam D.Haldipur, ParthivSaulnier, OlivierMillman, JakeSjoboen, Alexandria H.Erickson, Anders W.Ong, WinnieGordon, VictorCoudière-Morrison, LudivineMercier, Audrey L.Shokouhian, MohammadPollack, Ian F.López-Aguilar, EnriqueGillespie, G. YanceyVan Meter, Timothy E.Shofuda, TomokoVibhakar, RajeevThompson, Reid C.Cooper, Michael K.Rubin, Joshua B.Kumabe, ToshihiroAnsari, MarcJung, ShinLach, BoleslawLolascon, AchilleFerrucci, Veronicade Antonellis, PasqualinoZollo, MassimoCinalli, GiuseppeRobinson, ShenandoahStearns, Duncan S.Van Meir, Erwin G.Garre, Maria L.Porrati, PaolaFinocchiaro, GaetanoMassimino, MauraCarlotti, Carlos G.Faria, Claudia C.Roussel, Martine F.Boop, FrederickChan, Jennifer A.Aldinger, Kimberly A.Razavi, FerechteChico, FernandoSilvestri, EvelinaMcLendon, Roger E.Thompson, Eric M.Eguía, PilarPérezpeña, MarioMorrissy, A. SoranaCavalli, Florence M.G.Wu, XiaochongDaniels, CraigRich, Jeremy N.Suárez, Raúl A.Jones, Steven J.M.Moore, Richard A.Marra, Marco A.Huang, XiReimand, JüriSorensen, Poul H.Wechsler-Reya, Robert J.Weiss, William A.Pugh, Trevor J.Garzia, LiviaLy, MichelleKleinman, Claudia L.Stein, Lincoln D.Jabado, NadaMalkin, DavidAyrault, OlivierGolden, Jeffrey A.Ellison, David W.Doble, BradRamaswamy, VijayWerbowetski-Ogilvie, Tamra E.Borlase, StephanieSuzuki, HiromichiMillen, Kathleen J.Taylor, Michael D.Scott, David S.Vladoiu, Maria C.Farooq, HamzaSirbu, OlgaNakashima, TakumaNambu, ShoheiFunakoshi, YusukeBahcheli, AlecDiaz-Mejia, J. JavierGolser, JosephBach, KathleenPhuong-Bao, TramSkowron, PatrykWang, Evan Y.Kumar, Sachin A.Balin, PolinaVisvanathan, AbhiramiLee, John J.Y.Ayoub, RamyChen, XinChen, XiaodiMungall, Karen L.Luu, BettyBérubé, PierreWang, Yu C.Pfister, Stefan M.Kim, Seung KiDelattre, OlivierBourdeaut, FranckDoz, FrançoisMasliah-Planchon, JulienGrajkowska, Wieslawa A.Loukides, JamesDirks, PeterFèvre-Montange, MichelleJouvet, AnneFrench, Pim J.Kros, Johan M.Zitterbart, KarelBailey, Swneke D.Eberhart, Charles G.Rao, Amulya A.N.Giannini, CaterinaOlson, James M.Garami, MiklósHauser, PeterPhillips, Joanna J.Ra, Young S.de Torres, CarmenMora, JaumeLi, Kay K.W.Ng, Ho KeungPoon, Wai S.
Issue Date2022
Citation
Nature, 2022, v. 609, n. 7929, p. 1021-1028 How to Cite?
AbstractMedulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain1–4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage5–8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL9,10. However, little is known about the more commonly occurring group 4 (G4) MB, which is thought to arise in the unipolar brush cell lineage3,4. Here we demonstrate that somatic mutations that cause G4 MB converge on the core binding factor alpha (CBFA) complex and mutually exclusive alterations that affect CBFA2T2, CBFA2T3, PRDM6, UTX and OTX2. CBFA2T2 is expressed early in the progenitor cells of the cerebellar RL subventricular zone in Homo sapiens, and G4 MB transcriptionally resembles these progenitors but are stalled in developmental time. Knockdown of OTX2 in model systems relieves this differentiation blockade, which allows MB cells to spontaneously proceed along normal developmental differentiation trajectories. The specific nature of the split human RL, which is destined to generate most of the neurons in the human brain, and its high level of susceptible EOMES+KI67+ unipolar brush cell progenitor cells probably predisposes our species to the development of G4 MB.
Persistent Identifierhttp://hdl.handle.net/10722/325579
ISSN
2023 Impact Factor: 50.5
2023 SCImago Journal Rankings: 18.509
ISI Accession Number ID
Errata

 

DC FieldValueLanguage
dc.contributor.authorHendrikse, Liam D.-
dc.contributor.authorHaldipur, Parthiv-
dc.contributor.authorSaulnier, Olivier-
dc.contributor.authorMillman, Jake-
dc.contributor.authorSjoboen, Alexandria H.-
dc.contributor.authorErickson, Anders W.-
dc.contributor.authorOng, Winnie-
dc.contributor.authorGordon, Victor-
dc.contributor.authorCoudière-Morrison, Ludivine-
dc.contributor.authorMercier, Audrey L.-
dc.contributor.authorShokouhian, Mohammad-
dc.contributor.authorPollack, Ian F.-
dc.contributor.authorLópez-Aguilar, Enrique-
dc.contributor.authorGillespie, G. Yancey-
dc.contributor.authorVan Meter, Timothy E.-
dc.contributor.authorShofuda, Tomoko-
dc.contributor.authorVibhakar, Rajeev-
dc.contributor.authorThompson, Reid C.-
dc.contributor.authorCooper, Michael K.-
dc.contributor.authorRubin, Joshua B.-
dc.contributor.authorKumabe, Toshihiro-
dc.contributor.authorAnsari, Marc-
dc.contributor.authorJung, Shin-
dc.contributor.authorLach, Boleslaw-
dc.contributor.authorLolascon, Achille-
dc.contributor.authorFerrucci, Veronica-
dc.contributor.authorde Antonellis, Pasqualino-
dc.contributor.authorZollo, Massimo-
dc.contributor.authorCinalli, Giuseppe-
dc.contributor.authorRobinson, Shenandoah-
dc.contributor.authorStearns, Duncan S.-
dc.contributor.authorVan Meir, Erwin G.-
dc.contributor.authorGarre, Maria L.-
dc.contributor.authorPorrati, Paola-
dc.contributor.authorFinocchiaro, Gaetano-
dc.contributor.authorMassimino, Maura-
dc.contributor.authorCarlotti, Carlos G.-
dc.contributor.authorFaria, Claudia C.-
dc.contributor.authorRoussel, Martine F.-
dc.contributor.authorBoop, Frederick-
dc.contributor.authorChan, Jennifer A.-
dc.contributor.authorAldinger, Kimberly A.-
dc.contributor.authorRazavi, Ferechte-
dc.contributor.authorChico, Fernando-
dc.contributor.authorSilvestri, Evelina-
dc.contributor.authorMcLendon, Roger E.-
dc.contributor.authorThompson, Eric M.-
dc.contributor.authorEguía, Pilar-
dc.contributor.authorPérezpeña, Mario-
dc.contributor.authorMorrissy, A. Sorana-
dc.contributor.authorCavalli, Florence M.G.-
dc.contributor.authorWu, Xiaochong-
dc.contributor.authorDaniels, Craig-
dc.contributor.authorRich, Jeremy N.-
dc.contributor.authorSuárez, Raúl A.-
dc.contributor.authorJones, Steven J.M.-
dc.contributor.authorMoore, Richard A.-
dc.contributor.authorMarra, Marco A.-
dc.contributor.authorHuang, Xi-
dc.contributor.authorReimand, Jüri-
dc.contributor.authorSorensen, Poul H.-
dc.contributor.authorWechsler-Reya, Robert J.-
dc.contributor.authorWeiss, William A.-
dc.contributor.authorPugh, Trevor J.-
dc.contributor.authorGarzia, Livia-
dc.contributor.authorLy, Michelle-
dc.contributor.authorKleinman, Claudia L.-
dc.contributor.authorStein, Lincoln D.-
dc.contributor.authorJabado, Nada-
dc.contributor.authorMalkin, David-
dc.contributor.authorAyrault, Olivier-
dc.contributor.authorGolden, Jeffrey A.-
dc.contributor.authorEllison, David W.-
dc.contributor.authorDoble, Brad-
dc.contributor.authorRamaswamy, Vijay-
dc.contributor.authorWerbowetski-Ogilvie, Tamra E.-
dc.contributor.authorBorlase, Stephanie-
dc.contributor.authorSuzuki, Hiromichi-
dc.contributor.authorMillen, Kathleen J.-
dc.contributor.authorTaylor, Michael D.-
dc.contributor.authorScott, David S.-
dc.contributor.authorVladoiu, Maria C.-
dc.contributor.authorFarooq, Hamza-
dc.contributor.authorSirbu, Olga-
dc.contributor.authorNakashima, Takuma-
dc.contributor.authorNambu, Shohei-
dc.contributor.authorFunakoshi, Yusuke-
dc.contributor.authorBahcheli, Alec-
dc.contributor.authorDiaz-Mejia, J. Javier-
dc.contributor.authorGolser, Joseph-
dc.contributor.authorBach, Kathleen-
dc.contributor.authorPhuong-Bao, Tram-
dc.contributor.authorSkowron, Patryk-
dc.contributor.authorWang, Evan Y.-
dc.contributor.authorKumar, Sachin A.-
dc.contributor.authorBalin, Polina-
dc.contributor.authorVisvanathan, Abhirami-
dc.contributor.authorLee, John J.Y.-
dc.contributor.authorAyoub, Ramy-
dc.contributor.authorChen, Xin-
dc.contributor.authorChen, Xiaodi-
dc.contributor.authorMungall, Karen L.-
dc.contributor.authorLuu, Betty-
dc.contributor.authorBérubé, Pierre-
dc.contributor.authorWang, Yu C.-
dc.contributor.authorPfister, Stefan M.-
dc.contributor.authorKim, Seung Ki-
dc.contributor.authorDelattre, Olivier-
dc.contributor.authorBourdeaut, Franck-
dc.contributor.authorDoz, François-
dc.contributor.authorMasliah-Planchon, Julien-
dc.contributor.authorGrajkowska, Wieslawa A.-
dc.contributor.authorLoukides, James-
dc.contributor.authorDirks, Peter-
dc.contributor.authorFèvre-Montange, Michelle-
dc.contributor.authorJouvet, Anne-
dc.contributor.authorFrench, Pim J.-
dc.contributor.authorKros, Johan M.-
dc.contributor.authorZitterbart, Karel-
dc.contributor.authorBailey, Swneke D.-
dc.contributor.authorEberhart, Charles G.-
dc.contributor.authorRao, Amulya A.N.-
dc.contributor.authorGiannini, Caterina-
dc.contributor.authorOlson, James M.-
dc.contributor.authorGarami, Miklós-
dc.contributor.authorHauser, Peter-
dc.contributor.authorPhillips, Joanna J.-
dc.contributor.authorRa, Young S.-
dc.contributor.authorde Torres, Carmen-
dc.contributor.authorMora, Jaume-
dc.contributor.authorLi, Kay K.W.-
dc.contributor.authorNg, Ho Keung-
dc.contributor.authorPoon, Wai S.-
dc.date.accessioned2023-02-27T07:34:31Z-
dc.date.available2023-02-27T07:34:31Z-
dc.date.issued2022-
dc.identifier.citationNature, 2022, v. 609, n. 7929, p. 1021-1028-
dc.identifier.issn0028-0836-
dc.identifier.urihttp://hdl.handle.net/10722/325579-
dc.description.abstractMedulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain1–4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage5–8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL9,10. However, little is known about the more commonly occurring group 4 (G4) MB, which is thought to arise in the unipolar brush cell lineage3,4. Here we demonstrate that somatic mutations that cause G4 MB converge on the core binding factor alpha (CBFA) complex and mutually exclusive alterations that affect CBFA2T2, CBFA2T3, PRDM6, UTX and OTX2. CBFA2T2 is expressed early in the progenitor cells of the cerebellar RL subventricular zone in Homo sapiens, and G4 MB transcriptionally resembles these progenitors but are stalled in developmental time. Knockdown of OTX2 in model systems relieves this differentiation blockade, which allows MB cells to spontaneously proceed along normal developmental differentiation trajectories. The specific nature of the split human RL, which is destined to generate most of the neurons in the human brain, and its high level of susceptible EOMES+KI67+ unipolar brush cell progenitor cells probably predisposes our species to the development of G4 MB.-
dc.languageeng-
dc.relation.ispartofNature-
dc.titleFailure of human rhombic lip differentiation underlies medulloblastoma formation-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41586-022-05215-w-
dc.identifier.pmid36131014-
dc.identifier.scopuseid_2-s2.0-85138487209-
dc.identifier.volume609-
dc.identifier.issue7929-
dc.identifier.spage1021-
dc.identifier.epage1028-
dc.identifier.eissn1476-4687-
dc.identifier.isiWOS:000857475800001-
dc.relation.erratumdoi:10.1038/s41586-022-05578-0-
dc.relation.erratumeid:eid_2-s2.0-85142930235-

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